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| 1 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 2 | Potential release of hydrogen fluoride from domestic coal in endemic fluorosis area in Guizhou,China显示文摘Almost half of the total rural area of Guizhou Province and many regions within the 11 adjacent provinces in southwestern China have a long history(at least 70 years) of endemic fluorosis,including dental fluorosis and osteofluorosis along with its associated deformities and disabilities.Over decades of research,this specific type of endemic fluorosis has been defined as coal-burning fluorosis,which is distinct from drinking-water fluorosis.It is generally acknowledged that indoor burning and combustion of high-fluorine coal leads to food contamination,and fluorine then enters the human body.However,the exact chemical form of fluorine during its release and transfer to the body is still unknown.In the present study,21 domestic coal samples from outcrop and semi-outcrop coal collected in five villages with fluorosis were analyzed by time-of-flight secondary ion mass spectrometry(TOF-SIMS).The total mass fraction of sulfur in the samples ranged from 0.24%-5.58% and total fluorine content ranged 90.2-149.2 mg/kg.H3O+,H2SO4+ and HSO4-were detected in the samples by TOF-SIMS,which indicated that sulfuric acid hydrate(H2SO4.H2O) was present in the samples.F-was detected in all of these,which suggested the samples contain ionic fluorine compounds.Under certain circumstances,such as heating or burning,the prevalence and coexistence of the acid(H2SO4.H2O) and base(F-) would lead to a neutralization reaction producing volatile hydrogen fluoride(HF,bp = 19.5℃).This would be the chemical form of fluorine released from the coal.Further studies using HF and SO2 test tubes on headspace gas over coal samples heated to 200℃ in the laboratory and on headspace gas over stoves or chimney tops at rural residences confirmed the release of HF. | LIANG HanDong LIANG YanCi GARDELLA Joseph A. Jr HE Ping YATZOR Brett p | 2011 | Chinese Science Bulletin2011，56，22： | 12 |
| 3 | Quality control measures for lowering the seroconversion rate of hemodialysis patients with hepatitis B or C virus显示文摘BACKGROUND: Hemodialysis (HD) patients are at high risk of infection by hepatitis B virus (HBV) or hepatitis C virus (HCV). The present study was designed to determine the impact of quality control measures on the prevention of transmission of blood-borne viruses. METHODS: A total of 6182 adult maintenance HD patients from all HD units in Zhejiang Province were recruited on January 1, 2007. The baseline demographic and clinical characteristics were recorded and all patients were followed up until death or survival at 4 years later. The Quality Control Standards of Hemodialysis were gradually implemented in HD units. The HBV or HCV seroconversion rates of the recruited patients were calculated and compared every year during the observation period. RESULTS: The prevalence of HBV was 8.3% at the beginning of the study, and 6.6% for HCV. With the implementation of the HD quality control measures, the HBV seroconversion rate tended to decrease year by year (χ 2 =6.620, P=0.085), and the HCV seroconversion rate decreased significantly (χ 2 =10.41, P=0.015). Compared with the data in 2007, the HBV seroconversion rate (χ 2 =4.204, P=0.040, relative risk ratio 0.393, 95% CI 0.156-0.991) and the HCV seroconversion rate (χ 2 =7.373, P=0.007, relative risk ratio 0.386, 95% CI 0.189-0.787) decreased significantly in 2010. CONCLUSION: Quality control measures for HD decreased the seroconversion rates of HBV or HCV in HD patients, showing that updated quality control measures reduce the risk for transmission of blood-borne viruses in the HD population. | Jing Yuan,Yi Yang, Fei Han, Ping Zhang, Xiao-Ying Du, Hua Jiang and Jiang-Hua Chen The Kidney Disease Center, First Affiliated Hospital, Zhejiang University School of Medicine (Yuan J, Yang Y, Han F, Zhang P, Du XY, Jiang H and Chen JH) and Hemodialysis Quality Control Center of Zhejiang Province (Yuan J, Zhang P, Du XY and Chen JH), Hangzhou 310003, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 2 |
| 4 | Ischemia preconditioning induces selective translocation of protein kinase C isoforms epsilon and eta in the heart of concious rabbits without subcellar redistribution of total protein kinase C activity显示文摘 | Zhang J Qiu Y | 1997 | Circ Res1997，81，3： | 1 |
| 5 | Research on the parameters and performances of a 4QT prototype machine used for HEV显示文摘 | Zheng Ping Liu Ranran Thelin P | 2007 | IEEE Transactions onMagnetics2007，43，1： | 1 |
| 6 | Discovery of novel steroidal pyranoxindole hybrids as cytotoxic agents显示文摘 | Bin Y Ping P Q Xiao J S | 2014 | Steroids2014，88，： | 1 |
| 7 | Intercoronary gene transfer of fibroblast growth factor-5 increase blood flow contractile function in ischemia region of the heart显示文摘 | Ping P Mckirnau D | 1996 | Nature Med1996，2，3： | 1 |
| 8 | Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy显示文摘 | Takeishi Y Ping P Bolli R | 2000 | Circ Res2000，86，： | 1 |
| 9 | A frequency control method for regulating wireless power to implantable devices显示文摘 | SI Ping HU A P -MALPAS S | 2008 | IEEE Transactions on Biomedical Circuits and Systems2008，2，1： | 1 |
| 10 | Fine-resolution mapping of soil organic carbon based on multivariate secondary data显示文摘 | Simbahan G.C Dobermann A Goovaerts P Ping J.and Haddix M.L | | 0，，： | 1 |
| 11 | Cardiac toxic effects of trans-2-hexenal are mediated by induction of cardiomyocyte apoptotic pathways显示文摘 | Ping P Baines CP Gu Y | 2003 | Cardiovasc Toxicol2003，3，4： | 1 |
| 12 | Support vector machines with simulated annealing algorithms in electricity load forecasting显示文摘 | Ping F P Wei C H | 2005 | Energy Conversion and Management2005，，46： | 1 |
| 13 | Thermal runaway caused fire and explosion of lithium ion battery显示文摘 | Wang Q S Ping P Zhao X J | 2012 | Journal of Power Sources2012，208，： | 1 |
| 14 | Functional proteomic analysis of protein kinase C epsilon signaling complexes in the normal heart and during cardioprotection 显示文摘 | Zhang J Pierce WM Jr | 2001 | Circ Res2001，88，1： | 1 |
| 15 | PKC-dependent activation of p44/p42MAPKs during myocardial ischemia-reperfusion in conscious rabbits显示文摘 | Ping P Zhang J Cao X | 1999 | Am J Physiol1999，276，： | 1 |
| 16 | Multiplex PCR for simultaneous detection of 677C→T and 1298A→C polymorphisms in methylenetetrahydrofolate reductase gene for population studies of cancer risk 显示文摘 | Ping Yi Igor P Pogribny S | 2002 | Cancer letter2002，181，2： | 1 |
| 17 | Functional proteomic analysis of PKCe signaling complexes in the normal heart and during cardioprotection显示文摘 | Zhang J Pierce WM Jr | 2001 | Circ Res2001，88，： | 1 |
| 18 | Calcium ion influx in microglial cells: physiological and therapeutic significance 显示文摘 | Sharma P Ping L | 2014 | J Neurosci Res2014，92，4： | 1 |
| 19 | Detecting and characterizing N-acyl-homoserine lactone signal molecules by thin-layer chromatography显示文摘 | Shaw P D Ping G Daly S L | 1997 | Proc Natl Acad Sci USA1997，94，12： | 1 |
| 20 | PKC-dependent activation of P46/P54 JNKs during ischemic preconditioning in conscious rabbits显示文摘 | Ping P Zhang J Huang S | 1999 | Am J Physiol1999，277，： | 1 |
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