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| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | Insights into gastric neuroendocrine tumors burden显示文摘Type 1 gastric neuroendocrine tumors(g NETs)are usually small lesions,restricted to mucosal and sub-mucosal layers of corpus and fundus,with low aggressive behavior,for the majority of cases.Nevertheless,some cases present aggressive behavior.The increasing incidence of g NETs brings together a new relevant problem:how to identify potentially aggressive type 1 g NETs.The challenging problem seems to be finding out signs or features able to predict potentially aggressive cases,allowing a tailored approach,since the involved societies dedicated to provide guidelines for management of these neoplasms apparently failed in producing staging systems able to accurately predict prognosis of these tumors.Additionally,it is also important to try to find out explanations for increasing incidence,as well as to identify potential targets aiming to reach better control of this neoplasia.Here,we discuss potential pathways implicated in aggressive behavior,as well as new strategies to improve clinical management of these tumors. | Taíssa Maíra Thomaz Araújo Williams Fernandes Barra André Salim Khayat Paulo Pimentel de Assumpcao | 2017 | Chinese Journal of Cancer Research2017，29，2： | 7 |
| 3 | Multiple deep granuloma annulare limited to the cephalic segment in childhood 显示文摘 | Neto Pimentel DR Michalany N De Abreu MA | 2008 | Pediatr Dermatol2008，25，3： | 1 |
| 4 | The association between the neutrophil-to-lymphocyte ratio and mortality in criti- cal illness : an observational cohort study 显示文摘 | Salciccioli JD Marshall DC Pimentel MA | 2015 | Crit Care2015，19，： | 1 |
| 5 | Treatment of recurrent aphthous stomatitis with clofazimine显示文摘 | de Abreu MA Hirata CH Pimentel DR | 2009 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2009，108，5： | 1 |
| 6 | Dynamic mutation and human disorders: the spinocerebellar ataxias显示文摘 | Costa Lima MA Pimentel MM | 2004 | Int J Mol Med2004，13，2： | 1 |
| 7 | Localization of the hand motor area by arterial spin labeling and blood oxygen level-dependent functional magnetic resonance imaging显示文摘 | PIMENTEL MA VILELA P SOUSA I | 2013 | Hum Brain Mapp2013，34，1： | 1 |
| 8 | Control of T Lymphocyte Activationand IL-2 Receptor Expression by EndogenouslySecreted Lymphokines显示文摘 | Pimentel Muinos FX Munoz Fernandez MA Fresno M | 1994 | J Immunol1994，152，： | 1 |
| 9 | Control of T lymphocyte activation and IL-2 receptor Expression by Endogenously Secreted Lymphokines显示文摘 | Pimentel Muinos FX Munoz Femandez MA Freson M | 1994 | J Immunol1994，152，： | 1 |
| 10 | Control of T Lymphoyte Activition and IL - 2 Receptor Expression by Endogenously Secreted Lymphokines 显示文摘 | Pimentel Muinos FX Munoz - Fernandez MA Fresno M | 1994 | J Immunol1994，152，： | 1 |
| 11 | Removal of heavy metals by an Aspergillus terreus strain immobilized in a polyurethane matrix 显示文摘 | Dias MA Lacerda IC Pimentel PF | 2002 | Lett Appl Microbiol2002，34，1： | 1 |
| 12 | Chronic stress acceler- ates pancreatic cancer growth and invasion : a critical role for beta- adrenergie signaling in the pancreatic microenvironment 显示文摘 | Kim-Fuchs C Le CP Pimentel MA | 2014 | Brain Behav Immun2014，40，： | 1 |
| 13 | Pigmented Paget's disease in a man previously treated with mammaplasty reduction for gynecomastia 显示文摘 | Pimentel CL Barnadas MA Dalmau J | 2006 | J Am Acad Dermatol2006，55，2： | 1 |
| 14 | Treatment of recurrent aphthous stomatitia with clofazimine显示文摘 | DE ABREU MA HIRATA CH PIMENTEL DB | 2009 | Oral surgery oral medicine oral pathology oral radiology and endodontics2009，108，5： | 1 |
| 15 | Granular parakeratosis in children:case report and review of the literature显示文摘 | Pimentel DR Michalany N Morgado de Abreu MA | | 0，，03： | 1 |
| 16 | Treatment of recurrent aphthous stomatitis with clofazimine显示文摘 | de Abreu MA Hirata CH Pimentel DR | 2009 | Oral surgery oral medicine oral pathology oral radiology and endodontics2009，108，5： | 1 |
| 17 | Treatment of recurrent aphthous stomatitis with clofazimine 显示文摘 | de Abreu MA Hirata CH Pimentel DR | 2009 | Oral Surg Oral Meal Oral Pathol Oral Radiol Endod2009，108，5： | 1 |
| 18 | A Review of Laser Treatment for Symptomatic BPH (Benign Prostatic Hyperplasia)显示文摘 | Nair SM Pimentel MA Gilling PJ | 2016 | Curr Urol Rep2016，17，6： | 1 |
| 19 | Control of T Lymphocyte Activationand IL-2 Receptor Expression by Endogenously Secreted Lymphokines显示文摘 | Pimentel Muinos FX Munoz-Fernandez MA Fresno M | 1994 | J Immunol1994，152，： | 1 |
| 20 | Identification of IL11RA and MELK amplification in gastric cancer by comprehensive genomic profiling of gastric cancer cell lines显示文摘AIM To identify common copy number alterations on gastric cancer cell lines.METHODS Four gastric cancer cell lines(ACP02, ACP03, AGP01 and PG100) underwent chromosomal comparative genome hybridization and array comparative genome hybridization. We also confirmed the results by fluorescence in situ hybridization analysis using the bacterial artificial chromosome clone and quantitative real time PCR analysis.RESULTS The amplification of 9p13.3 was detected in all cell lines by both methodologies. An increase in the copy number of 9p13.3 was also confirmed by fluorescence in situ hybridization analysis. Moreover, the interleukin 11 receptor alpha(IL11RA) and maternal embryonic leucine zipper kinase(MELK) genes, which are present in the 9p13.3 amplicon, revealed gains of the MELK gene in all the cell lines studied. Additionally, a gain in the copy number of IL11 RA and MELK was observed in 19.1%(13/68) and 55.9%(38/68) of primary gastric adenocarcinoma samples, respectively. CONCLUSION The characterization of a small gain region at 9p13.3 in gastric cancer cell lines and primary gastric adenocarcinoma samples has revealed MELK as a candidate target gene that is possibly related to the development of gastric cancer. | Danielle Queiroz Calcagno Sylvia Santomi Takeno Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Elizabeth Suchi Chen Taíssa Maíra Thomaz Araújo Eleonidas Moura Lima Maria Isabel Melaragno Samia Demachki Paulo Pimentel Assumpcao Rommel Rodriguez Burbano Marília Cardoso Smith | 2016 | World Journal of Gastroenterology2016，22，43： | 0 |
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