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| 1 | Efficiency of HAART in the prevention of mother to children HIV-1 transmission at Saint Camille medical centre in Burkina Faso,West Africa显示文摘Objective:To evaluate efficiency of HAART in the prevention of mother to child HIV transmission.Methods:A longitudinal study was conducted on 1 300 women attending the antenatal service at Saint Camille Medical Centre from September 2010 to July 2011.The HIV status of mothers was determined by rapid tests and EUSA.Discordant results were confirmed by real-time PCR.PCR was used to determine HIV status of children born from HIV-positive mothers.Results:Among 1 300 pregnant women tested for HIV,378 were seropositive.Mothers were predominantly housewives(69.7%),and their mean age was(28.32±0.15) years.The overall prevalence of HIV transmission from mother to child was 4.8%(18/378).This prevalence differed significantly from 0.0%(0/114) to 6.8%(18/264) in children born from mothers under HAART and those with mothers under New Prophylactic Protocol(ACT + 3TC + NVP),respectively(P< 0.01).Children’s mortality rate during the medical follow up was 1.3%(5/378).Among 16 women with HIV dubious status by ELISA,the Real Time PCR confirmed 2/16(12.5%) as HIV positive. Conclusions:The protocol of prevention of mother to children HIV transmission(PMTCT) is effective.The rate of HIV vertical transmission is significantly reduced.Early diagnosis determined by PCR of children born from HIV- positive mother is necessary and recommended in the context of PMTCT in Burkina Faso.We also found that PCR is an effective tool to confirm HIV status in pregnant women. | Laure Stella Ghoma Linguissi Cyrille Bisseye Tani Sagna Bolni Marius Nagalo Djeneba Ouermi Florencia W Djigma Salvatore Pignatelli Joseph D Sia Virginio Pietra Remy Moret Jean Baptiste Nikiema Jacques Simpore | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 4 |
| 2 | Antimicrobial resistance of abnormal vaginal discharges microorganisms in Ouagadougou,Burkina Faso显示文摘Objective:To assess the prevalence of bacterial strains and fungal strains infecting the vaginal tract and test their sensitivity to antibiotics in women attending Saint Camille Medical Centre in Ouagadougou.Methods:From January 2008 to December 2009,a total of 2000 vaginal swabs were cultivated for bacterial and fungal identification and isolation.Furthermore,bacterial strains were tested for their susceptibility to several antibiotics used in routine in the centre. Results:The results revealed that microbial isolation and identification was attempted for 1536/2000 sample,a positivity rate of 76.80%.Candida albicans(48.76%),followed by Escherichia coli(16.67%),Streptococcus agalactiae(8-14%) and Staphylococcus aureus(7.55%) were the major agents of genital tract infections in patients.Mycoplasma hominis and Ureaplasma urealyticum combined accounted for less than 7%.Trichomonas vaginalis was identified in 1.04%coses.The antimicrobial tests revealed that the microorganisms developed resistance to several antibiotics including beta lactams.However,antibiotics such as cefamenzol,ciprofloxacin and norfloxacin were still active on these bacteria.Conclusions:The results reveal that many sexually active women are infected by one or more microbial pathogens,probably because of the lock of hygiene or the adoption of some risky behaviors,such as not using condoms or having multiple sexual partners.Efforts should be made to address these points in the country. | Simplice D Karou Florencia Djigma Tani Sagna Christelle Nadembega Moctar Zeba Aboudoulaye Kabre Kokou Anani Djeneba Ouermi Charlemagne Gnoula Virginio Pietra Salvatore Pignatelli Jacques Simpore | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，4： | 2 |
| 3 | A multitargeted, metronomic, and maximum-tolerated dose ' chemo-switch' regimen is anti- angiogenic, producing objective responses and survival benefit in a mouse model of cancer 显示文摘 | Pietras K Hanahan D | 2005 | J Clin Oncol2005，23，5： | 1 |
| 4 | Clinical effect of driver mutations of JAK2, CALR, or MPL in primary myelofibrosis 显示文摘 | Rumi E Pietra D Pascutto C | 2014 | Blood2014，124，7： | 1 |
| 5 | JAK2 or CALR mutation status defines subtypes of essentialthrombocythemia with substantially different clinical course and outcomes显示文摘 | Rumi E Pietra D Ferretti V | 2014 | Blood2014，123，10： | 1 |
| 6 | Deep sequencing reveals double mutations in cis of MPL exon 10 in myeloproliferative neoplasms显示文摘 | Pietra D Brisci A Rumi E | | 0，，04： | 1 |
| 7 | IL-6 controls leukemic muhipotent progenitor cell fate and contributes to chronic myelogenous leukemia development 显示文摘 | REYNAUD D PIETRAS E BARRY-HOSLON K | 2011 | Cancer Cell2011，20，5： | 1 |
| 8 | Synthesis and biological evaluation of 2,3,5 -substituted thiadiazoles as allosteric modulators of adenosine receptors 显示文摘 | Nieuwendijk A M C H Pietra D Heitman L | 2004 | J Med Chem2004，47，3： | 1 |
| 9 | Relation between JAK2 (V617F) mutation status, granulocytic activation, and constitutive mobilization of CD34 cells into peripheral blood nmyeloproliferative disorders 显示文摘 | PASSAMONTI F RUMI E PIETRA D | 2006 | Blood2006，107，9： | 1 |
| 10 | JAK2 orCALR mutation status defines of essential thromboeythemia with substantially Different clinical course and outcomes显示文摘 | Rumi E Pietra D ferretti V | 2014 | Blood2014，123，10： | 1 |
| 11 | The Mathematics of statistical machine translation : Parameter estimation显示文摘 | Brown P F Pietra S A D Pietra V J D and Mercer R L | 1993 | Computational Linguistics1993，19，2： | 1 |
| 12 | HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells显示文摘 | PIETRAS R J ARBOLEDA J REESE D M | 1995 | Oncogene1995，10，12： | 1 |
| 13 | The mathematics of statistical machine translation: parameter estimation 显示文摘 | BROWN P PIETRA S D PIETRA V D | 1993 | Computational Linguistics1993，19，2： | 1 |
| 14 | CALR exon 9 mutations are somatically acquired events in familial cases of essential thrombocythemia or primary myelofibrosis显示文摘 | Rumi E Harutyunyan AS Pietra D | 2014 | Blood2014，123，15： | 1 |
| 15 | HPLC determination of glutathione and L-cysteine in pharmaceuticals after derivatization with ethacrynic acid显示文摘 | Pietra AMD Gotti R Bonazzi D | 1994 | Journal of Pharmaceutical & Biomedical Analysis1994，12，1： | 1 |
| 16 | Relation between J AK2 (V617F) mutation status,granulocyte activation, and constitutive mobilization of CD34+ cells into peripheral blood in myeloproliferative disorders显示文摘 | PASSAMONTI F RUMI E PIETRA D | 2006 | Blood2006，107，： | 1 |
| 17 | A maximum entropy approach to natural language processing显示文摘 | BERGER A L PIETRA V J D PIETRA S A D | 1996 | Computational Linguistics1996，22，1： | 1 |
| 18 | The Bcl I single nucleotide polymorphism of the human glucocorticoid receptor gene h - GR/ NR3C1 promoter in patients with bronchial asthma: pilot study显示文摘 | Pietras T Panek M Tworek D | 2011 | Mol Biol Rep2011，38，： | 1 |
| 19 | The mathematics of statistical machine translation: Param- eter estimation 显示文摘 | Brown P F Pietra V J D Pietra S A D | 1993 | Computational linguistics1993，19，： | 1 |
| 20 | Monoclonal antibody to HER-2/neu receptor modulates repair of radiation-induced DNA damage and enhances radiosensitivity of human breast cancer cells overexpressing this oncogene显示文摘 | Pietras RJ Poen JC Gallardo D | 1999 | Cancer Res1999，59，6： | 1 |
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