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| 1 | Pyroptosis: mechanisms and diseases显示文摘Currently,pyroptosis has received more and more attention because of its association with innate immunity and disease.The research scope of pyroptosis has expanded with the discovery of the gasdermin family.A great deal of evidence shows that pyroptosis can affect the development of tumors.The relationship between pyroptosis and tumors is diverse in different tissues and genetic backgrounds.In this review,we provide basic knowledge of pyroptosis,explain the relationship between pyroptosis and tumors,and focus on the significance of pyroptosis in tumor treatment.In addition,we further summarize the possibility of pyroptosis as a potential tumor treatment strategy and describe the side effects of radiotherapy and chemotherapy caused by pyroptosis.In brief,pyroptosis is a double-edged sword for tumors.The rational use of this dual effect will help us further explore the formation and development of tumors,and provide ideas for patients to develop new drugs based on pyroptosis. | Pian Yu Xu Zhang Nian Liu Ling Tang Cong Peng Xiang Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 26 |
| 2 | Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro显示文摘Eukaryotic elongation factor-2 kinase (eEF-2K), a negative regulator of protein synthesis, has been shown to play an important role in modulating autophagy and apoptosis in tumor cells under various stresses. In this study, we investigated the regulatory role of eEF-2K in pyroptosis (a new form of programmed necrosis) in doxorubicin-treated human melanoma cells. We found that doxorubicin (0.5-5 μmol/L) induced pyroptosis in melanoma cell lines SK-MEL-5, SK-MEL-28, and A-375 with high expression of DFNA5, but not in human breast cancer cell line MCF-7 with little expression of DFNA5. On the other hand, doxorubicin treatment activated autophagy in the melanoma cells;inhibition of autophagy by transfecting the cells with siRNA targeting Beclin1 or by pretreatment with chloroquine (20 μmol/L) significantly augmented pyroptosis, thus sensitizing the melanoma cells to doxorubicin. We further demonstrated that doxorubicin treatment activated eEF-2K in the melanoma cells, and silencing of eEF-2K blunted autophagic responses, but promoted doxorubicin-induced pyroptotic cell death. Taken together, the above results demonstrate that eEF-2K dictates the cross-talk between pyroptosis and autophagy in doxorubicin-treated human melanoma cells;suppression of eEF-2K results in inhibiting autophagy and augmenting pyroptosis, thus modulating the sensitivity of melanoma cells to doxorubicin, suggesting that targeting eEF-2K may reinforce the antitumor ef?cacy of doxorubicin, offering a new insight into tumor chemotherapy. | Pian Yu Hai-yan Wang Min Tian Ao-xue Li Xi-sha Chen Xin-luan Wang Yi Zhang Yan Cheng | 2019 | Acta Pharmacologica Sinica2019，40，9： | 19 |
| 3 | Regional homogeneity abnormalities in patients with tensiontype headache:a resting-state fMRI study显示文摘Tension-type headache(TTH) is the most prevalent type of primary headache. Many studies have shown that the pathogenesis of primary headache is associated with fine structural or functional changes. However, these studies were mainly based on migraine. The present study aimed to investigate whether TTH patients show functional disturbances compared with healthy subjects. We used restingstate functional magnetic resonance imaging(f MRI) and regional homogeneity(Re Ho) analysis to identify changes in the local synchronization of spontaneous activity in patients with TTH. Ten patients with TTH and 10 age-, gender-, and education-matched healthy controls participated in the study. After demographic and clinical characteristics were acquired, a 3.0-T MRI system was used to obtain restingstate f MRIs. Compared with healthy controls, the TTH group exhibited significantly lower Re Ho values in the bilateral caudate nucleus, the precuneus, the putamen, the left middle frontal gyrus, and the superior frontal gyrus. There was no correlation between mean Re Ho values in TTH patients and duration of TTH, number of attacks, duration of daily attacks, Visual Analogue Scale score, or Headache Impact Test-6 score. These results suggest that TTHpatients exhibit reduced synchronization of neuronal activity in multiple regions involved in the integration and processing of pain signals. | Pian Wang Handan Du Ning Chen Jian Guo Qiyong Gong Junran Zhang Li He | 2014 | Neuroscience Bulletin2014，30，6： | 6 |
| 4 | Suppression of eEF-2K-mediated autophagy enhances the cytotoxicity of raddeanin A against human breast cancer cells in vitro显示文摘最近的证据显示出那 raddeanin A (RA ) ,从海葵 raddeana Regel 提取的 oleanane 类型 triterpenoid saponin,在 vitro 并且在 vivo 对癌症房间施加显著 cytotoxicity。另外, RA 也被发现了在人的胃的癌症房间激活 autophagy。在这研究,我们调查了在 vitro 在人的乳癌房间象在导致 RA 的 autophagy 和它的 cytotoxicity 之间的关系一样位于导致 RA 的 autophagy 下面的分子的机制。有 RA (2-8 mol/L ) 的治疗 dose-dependently 提高了 autophagy,在乳癌房间线 T47D 由增加的 LC3 层次证实了 MCF-7 和 MDA-MB-231。而且,表明小径的 Akt-mTOR-eEF-2K 被表明在 3 根乳癌房间线涉及 autophagy 的导致 RA 的激活。有 RA (2-10 mol/L ) 的治疗 dose-dependently 在 3 根乳癌房间线导致了 apoptosis。有 autophagy 禁止者 chloroquine 的预告的处理(CQ, 20 mol/L ) 经由支持 apoptosis 的显著地提高的引起 RA 的 cytotoxicity。在结论,我们的结果建议 modulating autophagy 能对人的乳癌房间增强 RA 的 cytotoxicity。 | Yi-di GUAN Shi-long JIANG Pian YU Mei WEN Yi ZHANG Song-shu XIAO Xiao-jun XU Yan CHENG | 2018 | Acta Pharmacologica Sinica2018，39，4： | 6 |
| 5 | Occurrence of bisphenol A in surface and drinking waters and its physicochemical removal technologies显示文摘Bisphenol A (BPA ) ,内分泌的破坏混合物,在环境和有害效果由于它的宽出现引起了宽公共担心。BPA 与最大的集中在许多表面水和喝的水里被检测了直到十 | Liping LIANG Jing ZHANG Pian FENG Cong LI Yuying HUANG Bingzhi DONG Lina LI Xiaohong GUAN | 2015 | Frontiers of Environmental Science & Engineering2015，9，1： | 5 |
| 6 | Size and elemental composition of dry-deposited particles during a severe dust storm at a coastal site of Eastern China显示文摘Dry-deposited particles were collected during the passage of an extremely strong dust storm in March, 2010 at a coastal site in Qingdao(36.15°N, 120.49°E), a city located in Eastern China. The size, morphology, and elemental composition of the particles were quantified with a scanning electron microscope equipped with an energy dispersive X-ray instrument(SEM–EDX). The particles appeared in various shapes, and their size mainly varied from 0.4to 10 μm, with the mean diameters of 0.5, 1.5, and 1.0 μm before, during, and after the dust storm, respectively. The critical size of the mineral particles settling on the surface in the current case was about 0.3–0.4 μm before the dust storm and about 0.5–0.7 μm during the dust storm. Particles that appeared in high concentration but were smaller than the critical size deposited onto the surface at a small number flux. The elements Al, Si and Mg were frequently detected in all samples, indicating the dominance of mineral particles. The frequency of Al in particles collected before the dust storm was significantly lower than for those collected during and after the dust storm. The frequencies of Cl and Fe did not show obvious changes, while those of S, K and Ca decreased after the dust arrival. These results indicate that the dust particles deposited onto the surface were less influenced by anthropogenic pollutants in terms of particle number. | Hongya Niu Daizhou Zhang Wei Hu Jinhui Shi Ruipeng Li Huiwang Gao Wei Pian Min Hu | 2016 | Journal of Environmental Sciences2016，28，2： | 4 |
| 7 | 基于近红外光谱技术的大黄苏打片混合工艺终点判断方法的研究显示文摘目的:探究密度效应对模型性能的影响,旨在建立一种稳健性更好的模型来实现大黄苏打片混合终点的准确判断。创新点:通过将密度差异变量引入模型校正集中的方法,建立了一种稳健性更好的原辅料多组分定量校正模型。方法:利用15批样品建立包含密度效应和未包含密度效应的偏最小二乘回归校正模型,并利用模型对3个未知批次样品进行终点监测。同时,使用主成分分析-移动块标准偏差算法对3批样品混合终点进行定性判别。分别使用基于近红外光谱技术的定性、定量分析方法,实现对大黄苏打片混合终点进行准确监测的目的。结论:粉体密度效应对模型预测性能的提高起到了重要作用。与普通模型相比,本研究所开发的压力不敏感模型展示了更加稳健的预测性能,这种稳健建模策略具有一定的推广应用前景。 | Si-jun WU Ping QIU Pian LI Zheng LI Wen-long LI | 2020 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2020，21，11： | 3 |
| 8 | Hydroturbine operating region partitioning based on analyses of unsteady flow field and dynamic response显示文摘The operating states of hydroelectric generating units vary widely as the operating condition change. The details of the operating characteristics and the operating region partitioning method are discussed for two types of large Francis turbines in the Wanjiazhai Hydropower Plant and two same type large Kaplan turbines in the Shuikou Hydropower Plant. For the Wanjiazhai Hydropower units, the most critical factor affecting the operating stability is the hydraulic pressure fluctuations caused by the vortex rope in the draft tube. For Shuikou Hydropower units, the dynamic stresses as in the piston rod and the blade and the hydraulic thrust on the runner induced by the pressure fluctuations in the flow passage should be used to partition the operating regions. Analyzing the distribution cloud of operating characteristic factors which affects the operating stability in the hill-chart for each individual unit, the forbidden, stable and transient operating regions can be obtained. | WANG ZhengWei1, QIN Liang2, ZENG JiDi3, LIN JiaYang3, YANG JinYi4, CHEN WeiJiang4, LUO YongYao1 & YAN ZongGuo1 1 State Key Laboratory of Hydroscience and Engineering and Department of Thermal Engineering, Tsinghua University, Beijing 100084, China 2 Tianjin Dredging Company Ltd., Tianjin 300042, China 3 Fujian Shuikou Hydropower Station, Fuzhou 350800, China 4 Wanjiazhai Hydropower Station, Pian’guan 036412, China | 2010 | Science China(Technological Sciences)2010，53，2： | 2 |
| 9 | Highly efficient synthesis of 9-aminoxanthenes via the tandem reaction of arynes with salicyl N-tosylimines显示文摘有 aryne 的水杨酸基 N-tosylimines 的串联 insertionnucleophilic 环反应从 2-(trimethylsilyl ) 在 situ 产生了芳基 triflate 和 KF-18-crown-6 被开发了,在一步高效地提供 9-aminoxanthenes。 | Lin He Ji Xin Pian Jing Zhang Yuan Zhen Li | 2012 | Chinese Chemical Letters2012，23，12： | 2 |
| 10 | Weak magnetic field accelerates chromate removal by zero-valent iron显示文摘Weak magnetic field(WMF) was employed to improve the removal of Cr(VI) by zero-valent iron(ZVI) for the first time. The removal rate of Cr(VI) was elevated by a factor of 1.12–5.89 due to the application of a WMF, and the WMF-induced improvement was more remarkable at higher Cr(VI) concentration and higher p H. Fe2+was not detected until Cr(VI) was exhausted, and there was a positive correlation between the WMF-induced promotion factor of Cr(VI) removal rate and that of Fe2+release rate in the absence of Cr(VI) at pH 4.0–5.5. These phenomena imply that ZVI corrosion with Fe2+release was the limiting step in the process of Cr(VI) removal. The superimposed WMF had negligible influence on the apparent activation energy of Cr(VI) removal by ZVI, indicating that WMF accelerated Cr(VI)removal by ZVI but did not change the mechanism. The passive layer formed with WMF was much more porous than without WMF, thereby facilitating mass transport. Therefore,WMF could accelerate ZVI corrosion and alleviate the detrimental effects of the passive layer, resulting in more rapid removal of Cr(VI) by ZVI. Exploiting the magnetic memory of ZVI, a two-stage process consisting of a small reactor with WMF for ZVI magnetization and a large reactor for removing contaminants by magnetized ZVI can be employed as a new method of ZVI-mediated remediation. | Pian Feng Xiaohong Guan Yuankui Sun Wonyong Choi Hejie Qin Jianmin Wang Junlian Qiao Lina Li | 2015 | Journal of Environmental Sciences2015，27，5： | 2 |
| 11 | Consistency condition and convergence criteria of incompatible element: General formulation of incompatible functions and its application显示文摘 | WU C C Huang M G Pian T H H | 1987 | Computer & Structures1987，27，： | 2 |
| 12 | A rational approach for choosing stress terms for hybrid finite element formulation显示文摘 | T H H Pian C C Wu | 1988 | International Journal for Numerical Methods in Engineering1988，26，： | 2 |
| 13 | Chorea induced by non-ketotic hypergtycaemia: a case report显示文摘 | Branca D Gervasio O Le Piane E | 2005 | Neurol Sci2005，26，4： | 1 |
| 14 | Correlation between melphalan pharmacokinetics and hepatic toxicity following hyperthermic isolated liver perfusion for unresectable metastatic disease显示文摘 | Mocellin S Pilati P Da Pian P | 2007 | Ann Surg Oncol2007，14，： | 1 |
| 15 | Familial temporal lobe epilepsy autosomal dominant inheritance in a large pedigree from southern Italy 显示文摘 | Gambardella A Messina D Le Piane E | 2000 | Epilepsy Res2000，38，23： | 1 |
| 16 | Rational approach for assumed stress finite elements显示文摘 | Pian T H H Sumihara K | 1984 | International Journal for Numerical Methods Engineering1984，20，： | 1 |
| 17 | Derivation of element stiffness matrices 显示文摘 | Pian T H H | 1964 | AIAA1964，2，3： | 1 |
| 18 | Derivation of element stiffness matrices by assumed stress distributions显示文摘 | | 1964 | AIAA J1964，2，2： | 1 |
| 19 | Relations between incompatible displacement model and hybrid stress model显示文摘 | Pian T H H Tong P | 1986 | International Journal for Numerical Methods Engineering1986，22，： | 1 |
| 20 | Laparoscopic strip- ping of endometriomas negatively affects ovarian follicular reserve even if performed by experienced surgeons 显示文摘 | Biacchiardi CP ~ Piane LD Camanni M | 2011 | Reprod Biomed Online2011，23，6： | 1 |
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