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| 1 | 后循环大血管闭塞性卒中的血管内治疗策略:美国神经介入外科学会(SNIS)标准和指南委员会共识显示文摘后循环卒中大约占所有卒中的20%,但后循环急性大血管闭塞(pc-ELVO)仅占所有急性大血管闭塞性卒中的5%。尽管少见,但pc-ELVO患者往往病情严重,症状也不典型,良好预后率低。如何更好地对这些患者进行管理,是目前临床治疗的难点。近期,美国神经介入外科学会(SNIS)发布了一项关于后循环大血管闭塞性卒中的血管内治疗指南,旨在为pc-ELVO的影像学检查、诊断和血管内治疗技术提供详细的最新指导。 | Yasha Kayan Philip M Meyers Charles J Prestigiacomo Peter Kan Justin F Fraser 王丽娜(翻译) 刘焕(翻译) 贺迎坤(翻译) 邢莹(翻译) 何艳艳(翻译) 李天晓(翻译) 朱良付(翻译) 李钊硕(翻译) | 2019 | 中华介入放射学电子杂志2019，7，4： | 11 |
| 2 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 3 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 4 | Is the schatzki ring a unique esophageal entity?显示文摘AIM:To study,whether the association of Schatzki rings with other esophageal disorders support one of the theories about its etiology.METHODS:From 1987 until 2007,all patients with newly diagnosed symptomatic Schatzki rings (SRs) were prospectively registered and followed.All of them underwent structured interviews with regards to clinical symptoms,as well as endoscopic and/or radiographic examinations.Endoscopic and radiographic studies determined the presence of an SR and additional morphological abnormalities.RESULTS:One hundred and sixty-seven patients (125 male,42 female) with a mean age of 57.1±14.6 years were studied.All patients complained of intermittent dysphagia for solid food and 113 (79.6%) patients had a history of food impaction.Patients experienced symptoms for a mean of 4.7±5.2 years before diagnosis.Only in 23.4% of the 64 patients who had endoscopic and/or radiological examinations before their first presentation to our clinic,was the SR previously diagnosed.At presentation,the mean ring diameter was 13.9±4.97 mm.One hundred and sixty-two (97%) patients showed a sliding hiatal hernia.Erosive reflux esophagitis was found in 47 (28.1%) patients.Twenty-six (15.6%) of 167 patients showed single or multiple esophageal webs;five (3.0%) patients exhibited eosinophilic esophagitis;and four (2.4%) had esophageal diverticula.Four (7%) of 57 patients undergoing esophageal manometry had nonspecific esophageal motility disorders.CONCLUSION:Schatzki rings are frequently associated with additional esophageal disorders,which support the assumption of a multifactorial etiology.Despite typical symptoms,SRs might be overlooked. | Michaela Müller Ines Gockel Philip Hedwig Alexander J Eckardt Kathrin Kuhr Jochem Knig Volker F Eckardt | 2011 | World Journal of Gastroenterology2011，17，23： | 2 |
| 5 | Adenine intoxication in relation to in vivo formation and deposition of 2,8-dioxyadenine in renal tubules 显示文摘 | Philips F S Thiersh J B Bendie H A | 1990 | J Pharmacal Exp Ther1990，104，： | 1 |
| 6 | Adenine intoxication in relation to in vivo formation and deposition of 2,8-dioxyadenine in renal tubules显示文摘 | Philips F S Thiersch J B Bendich A | 1952 | J Pharmacal Exp Ther1952，104，1： | 1 |
| 7 | Antiepileptic drugs-best practice guidelines for therapeutic drug monitoring: A position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies 显示文摘 | Philip N David J Blaise F | 2008 | Epilepsia2008，49，7： | 1 |
| 8 | An updated scenario typology 显示文摘 | Van Philip W F N Rotmans J Marjolein B A | 2003 | Futures2003，35，5： | 1 |
| 9 | Aryl Amidine and Tertiary Amine Switchable Surfactants and Their Appli- cation in the Emulsion Polymerization of Methyl Meth- acrylate显示文摘 | Candace I F Philip G J Michael F C | 2012 | Macromolecules2012，45，7： | 1 |
| 10 | Experimental and numerical studies of the combustion of di-tertiary butyl peroxide in the presence of oxygen at low pressure in a mechanically stirred closed vessel 显示文摘 | Griffiths J F Philips C H | 1990 | Combustion and Flame1990，81，： | 1 |
| 11 | Regulatory aspec ts of cl onallyexpanded B1(CD5+B)cells显示文摘 | Raveche E S,Philips J,Mahboudi F | 1992 | Int J Clin Lab Res,1992，22，220： | 1 |
| 12 | 5, 10, 15,20-tetrakis(Nprotected-imidazol-2-yl)-porphyrins 显示文摘 | Milgrom LR Philip J F Gokhan Y | 1996 | Tetrahedron1996，52，29： | 1 |
| 13 | American Gastronterological Association Medical Position Statement: guidelines on constipation 显示文摘 | Locke G R Pemberton J H Philips S F | 2000 | Gastroenterology2000，119，6： | 1 |
| 14 | Triple melt- ingbehavior of poly ( ethylene terephthalate co 1, 4cyclohexanedimethylene terephthalate) random copolyes- ters显示文摘 | Medellin F J Philips P J Lin J S | 1998 | Journal of Polymer Science (Part B): Polymer Physics1998，36，： | 1 |
| 15 | Detection of gas in sandstone reservoirs using AVO analysis: A 3-D seismic case history using the Geostack technique 显示文摘 | Jan L F George C S Peter J V Peter J S Philip R L | 1994 | Geophysics1994，59，： | 1 |
| 16 | Detection of gas in sandstone reservoirs using AVO analysis:A 3-D seismic case history using the Geostack technique显示文摘 | Jan L F George C S Peter J V Peter J S Philip R L | 1994 | Geophysics1994，59，： | 1 |
| 17 | Missing data methods in PCA and PLS: Score calculations with incomplete observations 显示文摘 | Philip R C Nelson Taylor P A MacGregor J F | 1996 | Chemometrics and Intelligent Laboratory Systems (0169-7439)1996，35，： | 1 |
| 18 | Phylogenetic lineages in the Botryosphaeri- aceae显示文摘 | CROUS P W SLIPPERS B WINGFIELD M J RHEEDER J MARASAS W F PHILIPS A J ALVES A BURGESS T BARBER P GROENEWALD J Z | 2006 | Studies in Mycology2006，55，： | 1 |
| 19 | Impact craters and Venus resurfacing history 显示文摘 | Philips R J Raubertas R F Arvidson R E | 1992 | Journal of Geophysical Research1992，97，15： | 1 |
| 20 | Quantitative trait loci affecting peak bone mineral density in mice显示文摘 | KLEIN R F MITCHELL S R PHILIPS T J | 1998 | J Bone Miner Res1998，13，11： | 1 |
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