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| 1 | Inhibition of the G9a/GLP histone methyltransferase complex modulates anxiety-related behavior in mice显示文摘Epigenetic 基因规定畸形包括精神分裂症和消沉在各种各样的 neuropsychiatric 混乱,以及在心情和焦虑的规定被含有。另外, epigenetic 机制涉及精神病学的药的行动。当前的 anxiolytic 药有新药的重要缺点,和开发被保证。二蛋白质, G9a (也作为 EHMT2 或 KMT1C 知道) 并且 GLP (象 G9a 一样蛋白质,也作为 EHMT1 或 KMT1D 知道) ,它甲醇化物离氨酸 9 histone H3 (H3K9 ) ,能正在答应 anxiolytic 目标。G9a 的出生后的基因大美人减少焦虑相关的行为,与由过去常对待焦虑(amitriptyline, imipramine 和 paroxetine ) 的一些药的 G9a 层次的减小一致。相反地,在有 GLP haplodeficiency 的老鼠有增加的像焦虑的行为。我们寻求了决定是否 G9a/GLP, UNC0642 和 A-366 的二个药理学禁止者,将有类似的效果到基因 G9a/GLP 不足。当予成年老鼠以时,我们发现有任何一个化合物的 G9a/GLP 抑制减少了像焦虑的行为,与在大脑的减少的 H3K9 methylation 一起。相反,到这些的暴露从胚胎的白天加重(E9.5 ) 9.5 增加了像焦虑的行为直到出生并且减少在成人生活的社会相互作用,当 H3K9 methylation 在在成年老鼠的大脑的正常层次时。这些调查结果增强 G9a/GLP 在大脑开发的不同阶段在像焦虑的行为上有不同效果的基因证据,并且建议指向这条 histone methyltransferase 小径能为开发新 anxiolytic 药是有用的。这些数据也建议在 utero 的抗抑郁剂暴露能在成人生活有否定效果,并且这些效果的进一步的调查被保证。 | Dong-yao WANG Joel KOSOWAN James SAMSOM Laura LEUNG Kai-lai ZHANG Ying-xiang LI Yan XIONG Jian JIN Arturas PETRONIS Gabriel OH Albert H C WONG | 2018 | Acta Pharmacologica Sinica2018，39，5： | 4 |
| 2 | Undernutrition, risk of malnutrition and obesity in gastroenterological patients: A multicenter study显示文摘AIM: To investigate the prevalence of undernutrition, risk of malnutrition and obesity in the Italian gastroenterological population. METHODS: The Italian Hospital Gastroenterology Association conducted an observational, cross-sectional multicenter study. Weight, weight loss, and body mass index were evaluated. Undernutrition was defined as unintentional weight loss > 10% in the last threesix months. Values of Malnutrition Universal Screening Tool(MUST) > 2, NRS-2002 > 3, and Mini Nutritional Assessment(MNA) from 17 to 25 identified risk of malnutrition in outpatients, inpatients and elderly patients, respectively. A body mass index ≥ 30 indicated obesity. Gastrointestinal pathologies were categorized into acute, chronic and neoplastic diseases. RESULTS: A total of 513 patients participated in the study. The prevalence of undernutrition was 4.6% in outpatients and 19.6% in inpatients. Moreover, undernutrition was present in 4.3% of the gastrointestinal patients with chronic disease, 11.0% of those with acute disease, and 17.6% of those with cancer. The risk of malnutrition increased progressively and significantly in chronic, acute and neoplastic gastrointestinal diseases in inpatients and the elderly population. Logistical regression analysis confirmed that cancer was a risk factor for undernutrition(OR = 2.7; 95%CI: 1.2-6.44, P = 0.02). Obesity and overweight were more frequent in outpatients. CONCLUSION: More than 63% of outpatients and 80% of inpatients in gastroenterological centers suffered from significant changes in body composition and required specific nutritional competence and treatment. | Massimiliano Rizzi Silvia Mazzuoli Nunzia Regano Rosa Inguaggiato Margherita Bianco Gioacchino Leandro Elisabetta Bugianesi Donatella Noè Nicoletta Orzes Paolo Pallini Maria Letizia Petroni Gianni Testino Francesco William Guglielmi | 2016 | World Journal of Gastrointestinal Oncology2016，8，7： | 2 |
| 3 | Recent advances on the regulation of anthocyanin synthesis in reproductive organs显示文摘 | Katia Petroni Chiara Tonelli | 2011 | Plant Science2011，，3： | 2 |
| 4 | CFOs and CEOs: Who have the most influence on earnings management?显示文摘 | John (Xuefeng) Jiang Kathy R. Petroni Isabel Yanyan Wang | 2010 | Journal of Financial Economics2010，，3： | 2 |
| 5 | Study of the trabecular projections (chordae Willisii) of the superior sagittal sinus显示文摘 | Petroni S Marrone AH | 1997 | Ital Anat Embryol1997，102，： | 1 |
| 6 | Discretionary and Non-Discretionary Revisions of Loss Reserves by Property-Casualty Insurers: Differential Implications for Future Profitability, Risk and Market Value显示文摘 | Kathy R. Petroni Stephen G. Ryan James M. Wahlen | 2000 | Review of Accounting Studies2000，，2： | 1 |
| 7 | Activation of mitogen- activated protein kinase associated with prostate cancer progression显示文摘 | Gioeli D Mandell JW Petroni GR | 1999 | Cancer Res1999，59，2： | 1 |
| 8 | Recent advances on the regulation of anthocyanin synthesis in reproductive organs 显示文摘 | Petroni K Tonelli C | 2011 | Plant Sci2011，181，3： | 1 |
| 9 | Activation of mitogen-activate protein kinase associated with prostate cancer progression显示文摘 | Gioeli D Mandell J W Petroni G R | 1999 | Cancer Res1999，59，2： | 1 |
| 10 | Locally Addressable Elec- trochemical Patterning Technique (LAEPT) applied to ,poly( L-ly-sine) -graft-poly( ethylene glycol) adlayers on titanium and silicon oxide surfaces显示文摘 | Tang CS Schmutz P Petronis S | 2005 | Biotechnol Bioeng2005，91，3： | 1 |
| 11 | Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis显示文摘 | Jonathan Mill Thomas Tang Zachary Kaminsky Tarang Khare Simin Yazdanpanah Luigi Bouchard Peixin Jia Abbas Assadzadeh James Flanagan Axel Schumacher Sun-Chong Wang Arturas Petronis | 2008 | The American Journal of Human Genetics2008，，3： | 1 |
| 12 | CARB-9, a carbenicillinase encoded in the VCR region of Vibrio cholerae non-O1, non-O139 belongs to a family of cassette-encoded beta-lactamases 显示文摘 | Petroni A Melano RG Saka HA | 2004 | Antimicrob Agents Chemother2004，48，10： | 1 |
| 13 | Fair Value of Equity and Debt Securities and Share Prices of Property - liability Insurers显示文摘 | Petroni K R Wahlen J M | 1995 | Journal of Risk and Insurance1995，62，4： | 1 |
| 14 | Proactive key distribution using neighbor graphs 显示文摘 | MISHR A SHIN M H PETRONI N J | 2004 | IEEE Wireless Communications2004，33，1： | 1 |
| 15 | Innovations as a determinant of suppliers roles and performance : An empirical study in the food machinery industry 显示文摘 | Petroni A Paneiroli B | 2002 | European Journal of Purchasing and Supply Management2002，8，3： | 1 |
| 16 | Intra aortic balloon pumpeffects on macrocirculation and microcirculation in cardiogenicshock patients supported by venoarterial extracorporeal membraneoxygenation显示文摘 | Petroni T Harrois A Amour J | 2014 | Critical Care Medicine2014，42，9： | 1 |
| 17 | Cherry picking, disclosure quality and comprehensive income reporting choices: The case of property-liability insurers显示文摘 | Lee Y J K Petroni K R Shen M | 2006 | Contemporary Accounting Research2006，23，3： | 1 |
| 18 | Low seminal zinc bound to high molecular weight proteins in asthenozoospermic patients: evidence of increased sperm zinc content in oligoasthenozoospermic patients 显示文摘 | Carpino A Siciliano L Petroni MF | 1998 | Hum Reprod1998，13，1： | 1 |
| 19 | CFOs and CEOs: Who Have the Most in? Hence on Earnings Manage-ment? 显示文摘 | Jiang J Petroni K R Wang L Y | 2010 | Journal of Financial Economics2010，，3： | 1 |
| 20 | Motivation strategles for knowledge workers:evidence and challenges显示文摘 | Petroni A Colacino P | | 0，，03： | 1 |
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