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| 1 | Chronic constipation in hemiplegic patients显示文摘AIM: To assess the prevalence of bowel dysfunction in hemiplegic patients, and its relationship with the site of neurological lesion, physical immobilization and pharmacotherapy. METHODS: Ninety consecutive hemiplegic patients and 81 consecutive orthopedic patients were investigated during physical motor rehabilitation in the same period, in the same center and on the same diet. All subjects were interviewed ≥ 3 mo after injury using a questionnaire inquiring about bowel habits before injury and at the time of the interview. Patients’ mobility was evaluated by the Adapted Patient Evaluation Conference System. Drugs considered for the analysis were nitrates, angiogenic converting enzyme (ACE) inhibitors, calcium antagonists, anticoagulants, antithrombotics, antidepressants, anti-epileptics. RESULTS: Mobility scores were similar in the two groups. De novo constipation (OR = 5.36) was a frequent outcome of the neurological accident. Hemiplegics showed an increased risk of straining at stool (OR: 4.33), reduced call to evacuate (OR: 4.13), sensation of incomplete evacuation (OR: 3.69), use of laxatives (OR: 3.75). Logistic regression model showed that constipation was significantly and independently associated with hemiplegia. A positive association was found between constipation and use of nitrates and antithrombotics in both groups. Constipation was not related to the site of brain injury. CONCLUSION: Chronic constipation is a possible outcome of cerebrovascular accidents occurring in 30% of neurologically stabilized hemiplegic patients. Its onset after a cerebrovascular accident appears to be independent from the injured brain hemisphere, and unrelated to physical inactivity. Pharmacological treatment with nitrates and antithrombotics may represent an independent risk factor for developing chronic constipation. | F Bracci D Badiali P Pezzotti G Scivoletto U Fuoco L Di Lucente A Petrelli E Corazziari | 2007 | World Journal of Gastroenterology2007，13，29： | 15 |
| 2 | Colorectal villous and tubulovillous adenomas equal to or greater than four centimeters 显示文摘 | Stulc JP Petrelli NJ Herrera L | 1988 | Ann Surg1988，207，： | 2 |
| 3 | Nerve growth factor:from neurotrophin to neurokine显示文摘 | Levi-Montalcini R Skaper SD Dal Toso R Petrelli L Leon A | 1996 | Trends Neurosci1996，19，11： | 1 |
| 4 | NMN/NaMN adenylyltransferase (NMNAT) and NAD kinase (NADK) inhibitors: chemistry and potential therapeutic applications 显示文摘 | Petrelli R K Felczak L Cappellacci | 2011 | Curr Med Chem2011，18，13： | 1 |
| 5 | Early postoperative oral feeding after colectomy: an analysis of fators that may predict failure显示文摘 | Petrelli N J Cheng C Driscoll D et a l | 2001 | Ann Surg Oncol2001，8，10： | 1 |
| 6 | Endothelin-1 and adrenomedullin enhance the growth of human adrenocortical carcinoma-derived SW-13 cell line by stimulating proliferation and inhibiting apoptosis显示文摘 | Albertin G Carraro G Petrelli L | 2005 | Int J Mol Med2005，15，3： | 1 |
| 7 | N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation显示文摘 | MAZZARI S CANELLA R PETRELLI L | 1996 | Eur J Pharmacol1996，300，3： | 1 |
| 8 | Ab-indu- ted ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity 显示文摘 | PETRELLI A CIRCOSTA P GRANZIERO L | 2006 | Proc Natl Acad Sci2006，103，13： | 1 |
| 9 | A Prospectve randomized trial of 5 - fluorouracil versus 5 -fluorouracil and high - dose leucovorin versus 5-fluorouracil and methotherte in previously untreated patients with advansed colorectal carcinoma 显示文摘 | Petrelli N Herrera L Rustan Y | 1987 | J Clin Oncol1987，5，： | 1 |
| 10 | Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage Ⅱ and Ⅲ colon cancer: results from NSABP C-07显示文摘 | Kuebler JP Wieand HS O’Connell MJ Smith RE Colangelo LH Yothers G Petrelli NJ Findlay MP Seay TE Atkins JN Zapas JL Goodwin JW Fehrenbacher L Ramanathan RK Conley BA Flynn PJ Soori G Colman LK Levine EA Lanier KS Wolmark N | 2007 | J Clin Oncol2007，25，16： | 1 |
| 11 | Solvents in pesticides 显示文摘 | Petrelli G Siepi G Miligi L | 1993 | Scand J Work Environ Health1993，19，： | 1 |
| 12 | Cell characterization of porcine aortic valve and decellularized leaflets repopulated with aortic valve interstitial cells:the VESALIO project (vitalitate exornatum succedaneum aorticum labore ingenioso obtenibitur)显示文摘 | Bertipaglia B Ortolani F Petrelli L | 2003 | Ann Thorac Surg2003，75，4： | 1 |
| 13 | Endothelin-1 and adrenomedullin enhance the growth of human adrenocortical carcinoma-derived SW-13 cell line by stimulating proliferation and inhibiting apoptosis显示文摘 | Albertin G Carraro G Petrelli L | 2005 | Int J Mol Med2005，15，3： | 1 |
| 14 | Solvents in pesticides显示文摘 | Petrelli G Siepi G Miligi L | 1993 | Scand J Work Environ Health1993，19，1： | 1 |
| 15 | Personalization in cultural herit- age: The road travelled and the one ahead显示文摘 | Ardissono L Kuflik T Petrelli D | 2012 | User Modeling and User-Adapted Interaction2012，22，12： | 1 |
| 16 | N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation显示文摘 | Mazzari S Canella R Petrelli L | 1996 | Eur J Pharmacol1996，300，3： | 1 |
| 17 | Treatment of bowel obstruction after operation for colorectal carcinoma 显示文摘 | Spears H Petrelli NJ Herrera L | 1998 | An J Surg1998，155，4： | 1 |
| 18 | Morbidity and mortality after pelvic exenteration for colorectal adenocarcinoma显示文摘 | Hafner GH Herrera L Petrelli NJ | 1992 | Ann Surg1992，215，1： | 1 |
| 19 | Treatment of bowel obstruction after operation for colorectal carcinoma显示文摘 | Spears H Petrelli NJ Herrera L | 1998 | Am J Surg1998，155，4： | 1 |
| 20 | A prospective randomized trial of 5 - fluorouracil versus 5 - flououracil and high - dose leucoverin versus 5 - flououracil and methothexatete in previously untreated patirnts with advanced colorectal carcinoma 显示文摘 | Petrelli N Herra L Rustan Y | 1987 | J Clin Oncol1987，5，： | 1 |
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