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| 1 | Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis显示文摘AIM: To investigate the relationship between osteopontin plasma concentrations and the severity of portal hypertension and to assess osteopontin prognostic value.METHODS: A cohort of 154 patients with confirmed liver cirrhosis(112 ethylic, 108 men, age 34-72 years)were enrolled in the study. Hepatic venous pressure gradient(HVPG) measurement and laboratory and ultrasound examinations were carried out for all patients. HVPG was measured using a standard catheterization method with the balloon wedge technique. Osteopontin was measured using the enzyme-linked immunosorbent assay(ELISA) method in plasma. Patients were followed up with a specific focus on mortality. The control group consisted of 137 healthy age- and sex- matched individuals.RESULTS: The mean value of HVPG was 16.18 ± 5.6 mm Hg. Compared to controls, the plasma levels of osteopontin in cirrhotic patients were significantly higher(P < 0.001). The plasma levels of osteopontin were positively related to HVPG(P = 0.0022, r = 0.25) and differed among the individual Child-Pugh groups of patients. The cut-off value of 80 ng/m L osteopontin distinguished patients with significant portal hypertension(HVPG above 10 mm Hg) at 75% sensitivity and 63% specificity. The mean follow-up of patients was 3.7 ± 2.6 years. The probability of cumulative survival was 39% for patients with HVPG > 10 mm Hg and 65% for those with HVPG ≤ 10 mm Hg(P = 0.0086, odds ratio(OR), 2.92, 95% confidence interval(CI): 1.09-7.76). Osteopontin showed a similar prognostic value to HVPG. Patients with osteopontin values above 80 ng/m L had significantly lower cumulative survival compared to those with osteopontin ≤ 80 ng/m L(37% vs 56%, P = 0.00035; OR = 2.23, 95%CI: 1.06-4.68).CONCLUSION: Osteopontin is a non-invasive parameter of portal hypertension that distinguishes patients with clinically significant portal hypertension. It is a strong prognostic factor for survival. | Radan Bruha Marie Jachymova Jaromir Petrtyl Karel Dvorak Martin Lenicek Petr Urbanek Tomislav Svestka Libor Vitek | 2016 | World Journal of Gastroenterology2016，22，12： | 20 |
| 2 | Probiotics in hepatology显示文摘The paper provides a basic review of intestinal micro- flora and its importance in liver diseases. The intestinal microflora has many important functions, above all to maintain the microbial barrier against established as well as potential pathogens. Furthermore, it influences the motility and perfusion of the intestinal wall, stimu- lates the intestinal immune system and therefore also the so-called common mucosal immune system, re- ducing bacterial translocation and producing vitamins. Immune homeostasis at mucosal level results from a controlled response to intestinal luminal antigens. In liver cirrhosis, there are many changes in its function, mostly an increase in bacterial overgrowth and trans- location. In this review, probiotics and their indications in hepatology are generally discussed. According to recent knowledge, these preparations are indicated in clinical practice only for cases of hepatic encephalopa- thy. Probiotics are able to decrease the permeability ofthe intestinal wall, and decrease bacterial translocation and endotoxemia in animal models as well as in clinical studies, which is extremely important in the prevention of complications of liver cirrhosis and infection after liv- er transplantation. Probiotics could limit oxidative and inflammatory liver damage and, in some situations, improve the histological state, and thus non-alcoholic steatohepatitis could be considered as another possible indication. ? 2011 Baishideng. All rights reserved. | Jan Lata Jana Jurankova Marcela Kopacova Petr Vitek | 2011 | World Journal of Gastroenterology2011，17，24： | 19 |
| 3 | Senescence-Inducible Expression of Isopentenyl Transferase Extends Leaf Life,Increases Drought Stress Resistance and Alters Cytokinin Metabolism in Cassava显示文摘Cassava(Manihot esculenta Crantz) sheds its leaves during growth,especially within the tropical dry season.With the production of SAG12-IPT transgenic cassava we want to test the level of leaf retention and altered cytokinin metabolism of transgenic plants via the autoregulatory senescence inhibition system.After confirmation of transgene expression by molecular analysis and phenotype examination in greenhouse plants,two transgenic plant lines,529-28 and 529-48,were chosen for further investigation.Detached mature leaves of 529-28 plants retained high levels of chlorophyll compared with wild-type leaves after dark-induced senescence treatment.Line 529-28 showed significant drought tolerance as indicated by stay-green capacity after drought stress treatment.Field experiments proved that leaf senescence syndrome was significantly delayed in 529-28 plants in comparison with wild-type and 529-48 plants.Physiological and agronomical characterizations of these plants also revealed that the induced expression of IPT had effects on photosynthesis,sugar allocation and nitrogen partitioning.Importantly,the 529-28 plants accumulated a high level of trans-zeatin-type cytokinins particularly of corresponding storage O-glucosides to maintain cytokinin homeostasis.Our study proves the feasibility of prolonging the leaf life of woody cassava and also sheds light on the control of cytokinin homeostasis in cassava leaves. | Peng Zhang Wen-Quan Wang Gen-Liang Zhang Miroslav Kaminek Petre Dobrev Jia Xu Wilhelm Gruissem | 2010 | Journal of Integrative Plant Biology2010，52，7： | 18 |
| 4 | Development tendencies of moulding and core sands显示文摘Further development of the technology for making moulding and core sands will be strictly limited by tough requirements due to protection of the natural environment. These tendencies are becoming more and more tense, so that we will reach a point when even processes, that from technological point of view fulfill high requirements of the foundry industry, must be replaced by more ecologically-friendly solutions. Hence, technologies using synthetic resins as binding materials will be limited. This paper presents some predictable development tendencies of moulding and core sands. The increasing role of inorganic substances will be noticed, including silicate binders with significantly improved properties, such as improved knock-out property or higher reclamation strength. Other interesting solutions might also be moulding sands bonded by geo-polymers and phosphate binders or salts and also binders based on degradable biopolymers. These tendencies and the usefulness of these binders are put forward in this paper. | Stanisaw M.Dobosz Petr Jelinek Katarzyna Major-Gabry | 2011 | China Foundry2011，8，4： | 11 |
| 5 | 欧洲被动式住房理念及其技术的发展与应用研究显示文摘通过对两个实例的分析介绍了近年来欧洲被动式住房的概念及其技术的发展,并对被动式住房的基本要素、标准、经济指标和国内的应用前景进行了初步探索。 | 陈翚 Petr Herman | 2011 | 建筑学报2011，，9： | 11 |
| 6 | ZnO@MOF@PANI core-shell nanoarrays on carbon cloth for high-performance supercapacitor electrodes显示文摘Hierarchical ZnO@metal-organic framework @polyaniline(ZnO@MOF@PANI) core-shell nanorod arrays on carbon cloth has been fabricated by combining electrodeposition and hydrothermal method. Well-ordered Zn O nanorods not only act as a scaffold for growth of MOF/PANI shell but also as Zn source for the formation of MOF. The morphology of ZnO@MOF@PANI composite is greatly influenced by the number of PANI electrodeposition cycles. Their structural and electrochemical properties were characterized with different techniques. The results indicate that the Zn O@MOF@PANI with 13 CV cycles of PANI deposition demonstrates the maximum specific capacitance of 340.7 F g-1 at 1.0 A g-1, good rate capability with84.3% capacitance retention from 1.0 to 10 A g-1 and excellent cycling life of 82.5% capacitance retention after 5000 cycles at high current density of 2.0 A g-1. This optimized core-shell nanoarchitecture endows the composite electrode with short ion diffusion pathway, rapid ion/electron transfer and high utilization of active materials, which thus result in excellent electrochemical performance of the ternary composite. | Chunmei Zhu Ying He Yijun Liu Natalia Kazantseva Petr Saha Qilin Cheng | 2019 | Journal of Energy Chemistry2019，28，8： | 10 |
| 7 | Treatment strategies for colorectal carcinoma with synchronous liver metastases: Which way to go?显示文摘AIM: To offer an up-to-date review of all availabletreatment strategies for patients with synchronous colorectal liver metastases(CLM).METHODS: A comprehensive literature search was performed to identify articles related to the management of patients with synchronous CLM. A search of the electronic databases PubMed, MEDLINE, and Google Scholar was conducted in September 2014.The following search terms were used: synchronous colorectal liver metastases, surgery, stage Ⅳ colorectal cancer, liver-first approach, and up-front hepatectomy.These terms were employed in various combinations to maximize the search. Only articles written in English were included. Particular attention was devoted to studies and review articles that were published within the last six years(2009-2014). Additional searches of the cited references from primary articles were performed to further improve the review. The full texts of all relevant articles were accessed by two independent reviewers.RESULTS: Poor long-term outcomes of patients with synchronous CLM managed by a traditional treatment strategy have led to questions about the timing and sequence of possible therapeutic interventions. Thus,alternative paradigms called reverse strategies have been proposed. Presently, there are four treatment strategies available:(1) primary first approach(or traditional approach) comprises resection of the primary colorectal tumor followed by chemotherapy;subsequent liver resection is performed 3-6 mo after colorectal resection(provided that CLM are still resectable);(2) simultaneous resection of the primary colorectal tumor and CLM during a single operation presents intriguing options for a highly select group of patients, which can be associated with significant postoperative morbidity;(3) liver-first(or chemotherapy-first) approach comprises preoperative chemotherapy(3-6 cycles) followed by liver resection,adjuvant chemotherapy, and resection of the primary colorectal tumor(it is best suited for patients withasymptomatic primary tumors and initially unresectable or marginally resectable CLM); and(4) up-front hepatectomy(or 'true' liver-first approach) includes liver resection followed by adjuvant chemotherapy,colorectal resection, and adjuvant chemotherapy(strategy can be offered to patients with asymptomatic primary tumors and initially resectable CLM).CONCLUSION: None of the aforementioned strategies appears inferior. It is necessary to establish individual treatment plans in multidisciplinary team meetings through careful appraisal of all strategies. | Peter Ihnát Petr Vávra Pavel Zonca | 2015 | World Journal of Gastroenterology2015，21，22： | 10 |
| 8 | Heavy rockbursts due to longwall mining near protective pillars:A case study显示文摘Rockburst represents a very dangerous phenomenon in deep underground mining in unfavourable conditions such as great depth, high horizontal stress, proximity of important tectonic structures, and unmined pillars. The case study describes a recorded heavy rockburst in the Czech part of the Upper Silesian Coal Basin, which occurred during longwall mining near the protective pillar. The artificial dividing of geological blocks and creation of mining protective pillars(shaft pillars, crosscut pillars etc.) is a dangerous task in light of rockbursts occurring mainly due to overstressing of remaining pillars. A simple model of this situation is presented. Natural and mining conditions are analysed and presented in detail as well as registered seismicity during longwall mining in the area. Recorded rockbursts in the area of interest are described and their causes discussed. Many rockbursts near protective pillars were recorded in this mining region. Methodical instructions for rockburst prevention in proximity of protective pillars as well as for gates driving were devised based on the evaluation of rockburst causes. The paper presents these principles for prevention. | Petr Konicek Jan Schreiber | 2018 | International Journal of Mining Science and Technology2018，28，5： | 9 |
| 9 | Catheter ablation of atrial fibrillation in elderly population显示文摘Background Although elderly patients have been included in published series of catheter ablation for atrial fibrillation (AF), clinicalbenefit and safety remain still less defined in this population. A retrospective analysis of the results of catheter ablation for AF in a large volumecenter focused on comparison of elderly patients with the rest of the patient cohort was conducted in this study. Methods Consecutive patientswho underwent catheter ablation for AF between January 2001 and December 2016 were analysed. A total population of 3197 patients wasdichotomized by the age of 70 years (394 elderly vs. 2803 younger subjects). Patients were followed in terms of arrhythmia status and sur-vival for a median period of 18 vs. 21 and 35 vs. 57 months, respectively. Results Elderly patients were more frequently females (49% vs.29%, P 〈 0.0001), had a history of hypertension (79% vs. 57%, P 〈 0.0001), diabetes (16% vs. 11%, P 〈 0.01), stroke (9% vs. 6%, P 〈 0.01),coronary/peripheral artery disease (14% vs. 8%, P 〈 0.0001), and CHAzDS2-VASc score (3.1 ± 1.3 vs. 1.5 ± 1.2 s, P 〈 0.0001). Major com-plications were more frequent in elderly (5.3% vs. 3.2%, P = 0.03); however, this difference was driven by vascular complications (3.6% vs.1.9%, P = 0.04). There were comparable rates of cerebrovascular (0.3 vs. 0.3%) or nonvascular complications (1.8 vs. 1.2%). Good arrhyth-mia control was inferior in elderly patients as compared with the rest of the cohort, both without and with antiarrhythmic drugs: 44.2% vs.58.2% (P 〈 0.0001) and 78.2 vs. 83.2% (P 〈 0.01), respectively. Poor arrhythmia control was associated with relative risk of all-cause mor-tality of 2.7 (95% CI: 1.1-6.4) in elderly patients and 1.4 (95% CI: 0.9-2.0) in younger subjects. Conclusions Catheter ablation for AF inelderly patients is safe although somewhat less effective. Good arrhythmia control is associated with better survival, especially in elderly patients. | Josef Kautzner Petr Peichl Marek Sramko Robert Cihak Bashar Aldhoon Dan Wichterle | 2017 | Journal of Geriatric Cardiology2017，14，9： | 9 |
| 10 | Subcellular Localization and In Vivo Interactions of the Arabidopsis thaliana Ethylene Receptor Family Members显示文摘气体的植物激素乙烯在更高的植物调整到环境条件的许多发展过程和回答。在 Arabidopsis thaliana,发信号的乙烯感觉和开始被与原核生物的二部件的传感器 histidine kinases 有关的五受体的一个家庭调停。在烟草(Nicotiana benthamiana ) 的标注荧光的受体的短暂表示表皮的叶房间证明所有乙烯受体被指向到 ER endomembrane 网络并且不本地化到 plasmalemma。在支持在 planta 覆盖研究,乙烯受体形式 homomeric 和 heteromeric,在在生活的 ER 的蛋白质建筑群种房间,由膜招募试金出现。在 vivo 相互作用模式可比较的 A 在酵母被发现基于配偶的 split-ubiquitin 系统。重叠但是乙烯受体基因的不同表示模式在不同植物纸巾建议乙烯受体建筑群的一篇微分作文。我们的调查结果可以在乙烯上有关键功能的含意荷尔蒙感觉,发信号的正式就职,信号变细和输出的调停受体的效率。 | Christopher Grefen Katrin Stadele Kamil Ruzicka Petr Obrdlik Klaus Hatter Jakub Horak | 2008 | Molecular Plant2008，1，2： | 8 |
| 11 | Technological advances in radiotherapy for esophageal cancer显示文摘Radiotherapy with concurrent chemotherapy and surgery represent the main treatment modalities in esophageal cancer.The goal of modern radiotherapy approaches,based on recent technological advances,is to minimize post-treatment complications by improving the gross tumor volume definition (positron emission tomography-based planning),reducing interfraction motion (image-guided radiotherapy) and intrafraction motion (respiratory-gated radiotherapy),and by better dose delivery to the precisely defined planning target volume (intensity-modulated radiotherapy and proton therapy).Reduction of radiotherapy-related toxicity is fundamental to the improvement of clinical results in esophageal cancer,although the dose escalation concept is controversial. | Milan Vosmik Jiri Petera Igor Sirak Miroslav Hodek Petr Paluska Jiri Dolezal Marcela Kopacova | 2010 | World Journal of Gastroenterology2010，16，44： | 8 |
| 12 | Cardiac rehabilitation and its essential role in the secondary prevention of cardiovascular diseases显示文摘Cardiovascular diseases are the most common causes of mortality worldwide.They are frequently the reasons for patient hospitalization,their incapability for work,and disability.These diseases represent a significant socio-economic burden affecting the medical system as well as patients and their families.It has been demonstrated that the etiopathogenesis of cardiovascular diseases is significantly affected by lifestyle,and so modification of the latter is an essential component of both primary and secondary prevention.Cardiac rehabilitation(CR)represents an efficient secondary prevention model that is especially based on the positive effect of regular physical activity.This review presents an overview of basic information on CR with a focus on current trends,such as the issue of the various training modalities,utilization,and barriers to it or the use of telemedicine technologies.Appropriate attention should be devoted to these domains,as CR continues evolving as an effective and readily available intervention in the future. | Petr Winnige Robert Vysoky Filip Dosbaba Ladislav Batalik | 2021 | World Journal of Clinical Cases2021，9，8： | 8 |
| 13 | High‑throughput sequencing view on the magnitude of global fungal diversity显示文摘High-throughput DNA sequencing has dramatically transformed several areas of biodiversity research including mycol-ogy.Despite limitations,high-throughput sequencing is nowadays a predominant method to characterize the alpha and beta diversity of fungal communities.Across the papers utilizing high-throughput sequencing approaches to study natural habitats in terrestrial ecosystems worldwide,>200 studies published until 2019 have generated over 250 million sequences of the primary mycological metabarcoding marker,the nuclear ribosomal internal transcribed spacer 2(ITS2).Here we show that at a 97%sequence similarity threshold,the total richness of non-singleton fungal taxa across the studies published so far is 1.08 million,mostly Ascomycota(56.8%of the taxa)and Basidiomycota(36.7%of the taxa).The Chao-1 estimate of the total extant fungal diversity based on this dataset is 6.28 million taxa,representing a conservative estimate of global fungal species richness.Soil and litter represent the habitats with the highest alpha diversity of fungi followed by air,plant shoots,plant roots and deadwood with Chao-1 predictions,for samples containing 5000 sequences,of 1219,569,392,228,215 and 140 molecular species,respectively.Based on the high-throughput sequencing data,the highest proportion of unknown fungal species is associated with samples of lichen and plant tissues.When considering the use of high-throughput sequenc-ing for the estimation of global fungal diversity,the limitations of the method have to be taken into account,some of which are sequencing platform-specific while others are inherent to the metabarcoding approaches of species representation.In this respect,high-throughput sequencing data can complement fungal diversity predictions based on methods of traditional mycology and increase our understanding of fungal biodiversity. | Petr Baldrian TomášVětrovský Clémentine Lepinay Petr Kohout | 2022 | Fungal Diversity2022，，3： | 8 |
| 14 | 糖尿病患者特殊功能鞋抗菌鞋垫的制备显示文摘制备了一种新的复配型抗菌剂(三氯新、尼泊金丁酯和2-氨基苯并噻唑/对甲酰基苯氧乙酸锌配合物(Zn(SD)2))乳液,并分别以喷洒和浸泡的方式对鞋里革和设计成型的PU发泡材料进行抗菌处理,以含少量该复配型抗菌剂的白乳胶将二者粘接起来,制备出能用于糖尿病患者特殊功能鞋的抗菌鞋垫,同时系统考察了水洗和汗液浸泡对其抗菌性能的影响。结果表明,以20 g/L的复配型抗菌剂乳液处理后的鞋里革、PU发泡材料以及由它们制备的鞋垫对细菌、酵母菌和霉菌都具有良好的抑制效果,但抑菌效果都随着水洗和汗液浸泡次数的增加而逐渐减弱,其中,水洗对鞋垫抗菌性能的影响要比汗液浸泡作用强得多。尽管如此,水洗20次或用汗液浸泡6次后,鞋垫仍然表现出较好的抑菌效果,对所有供试菌种的抑制率都在97%以上。 | 辜海彬 李萍萍 王利 黄妩 王向华 陈武勇 Petr Hlavacek | 2009 | 皮革科学与工程2009，19，2： | 7 |
| 15 | Comparative analysis of clinicopathological correlations of cyclooxygenase-2 expression in resectable pancreatic cancer显示文摘AIM:To perform a comparative analysis of clinicopathological correlations of cyclooxygenase2 (COX2) expression in pancreatic cancer, examined by monoclonal and polyclonal antibodies.METHODS: The COX2 expression in 85 resection specimens of pancreatic ductal adenocarcinoma was immunohistochemically examined using both monoclonal and polyclonal antibodies. The final immunoscores were obtained by multiplying the percentage of positive cells with the numeric score reflecting the staining intensity.COX2 expression levels were classified into three categories (0, 1+, and 2+) and the clinicopathological correlations were statistically evaluated and analyzed.RESULTS: The positive tumor expression rates of COX2 were 80.5% using monoclonal antibody and 69.4% using polyclonal antibody. In the KaplanMeier analysis, no significant correlations were found between levels of COX2 expression and overall survival (OS), but trends to longer OS were found in COX2 negative cases using monoclonal antibody. Significantly longer disease free survival was revealed in COX2 negative cases using monoclonal antibody (P = 0.019). No correlations between COX2 expression levels and grade (G), tumor (T) status and nodal (N) status were demonstrated. Low histological grade showed a strong association with a longer OS (P < 0.001). Correlation of survival and T status revealed a shorter OS in T3 tumors, but the results reached only marginal statistical significance (P = 0.070). In the multivariate Cox proportional hazards regression model, histological grade, T and N status remained valuable predictors of a worse survival with borderline significance for T [hazards ratio (HR) = 4.18 for G (if G = 3, P < 0.001); HR = 1.64 for T (if T = 3, P = 0.065); HR = 2.53 for N (if N = 1, P = 0.006)]. Higher grade, T or N status was associated with a worse OS. CONCLUSION: The immunohistochemically assessed level of COX2 expression does not seem to represent a valuable independent prognostic factor and is not superior to the conventional prognostic factors. | Marketa Hermanova Petr Karasek Jiri Tomasek Jiri Lenz Jiri Jarkovsky Petr Dite | 2010 | World Journal of Gastroenterology2010，16，15： | 7 |
| 16 | 表面活性剂对酶与皮胶原作用体系的影响显示文摘分别在胰酶和AS1.398酶溶液中添加不同量的十二烷基苯磺酸酯钠(阴离子型表面活性剂)、十二烷基三甲基氯化铵(阳离子型表面活性剂)和平平加O(非离子型表面活性剂),测定它们对酶活的影响。试验表明:只有非离子型表面活性剂对酶活起到激活作用。为进一步证实此结果也适用于实际应用中,在裸皮软化工序中分别加入这3种表面活性剂,测定软化液中蛋白质含量,观察软化皮的组织学以研究弹性纤维的破坏程度。将软化皮进行浸酸、铬鞣,并测定铬鞣革物理性能。试验表明:在软化工序中只有加入非离子型表面活性剂后,酶对弹性纤维水解程度明显,且鞣制后革的物理性能有所提高。研究表明:在进行酶软化时,应优先选择非离子表面活性剂。 | 左秋 陈武勇 Petr Hlavacek | 2009 | 中国皮革2009，38，21： | 7 |
| 17 | 表面活性剂对制革浸酸工序的影响显示文摘将十二烷基硫酸酯钠(阴离子型表面活性剂)、十二烷基三甲基氯化铵(阳离子型表面活性剂)和平平加O(非离子型表面活性剂)分别以不同用量添加到浸酸液中,观察浸酸工序完成所需要的时间,测定浸酸废液蛋白质含量和悬浮物含量,并对浸酸皮组织切片进行显微镜观察。将浸酸皮进行铬鞣,对铬鞣革进行感官评价,并测定铬鞣革收缩温度和抗张强度。研究结果表明:在浸酸液中添加阴离子型、阳离子型和非离子型表面活性剂,均能加快浸酸速度;当浸酸液中表面活性剂浓度略大于其临界胶束浓度时,表面活性剂就能明显加速浸酸过程;三类表面活性剂使浸酸皮胶原纤维分散的程度依次为:阴离子型表面活性剂>非离子型表面活性剂>阳离子型表面活性剂;将表面活性剂应用于浸酸工序后,所得蓝革柔软度、粒面平细度以及粒纹清晰程度均优于空白样,并且表面活性剂处理样抗张强度均高于空白样。 | 龚英 陈武勇 郭成兵 杨琦琪 Petr Hlavacek | 2007 | 皮革科学与工程2007，17，6： | 6 |
| 18 | Pathological changes in the cellular structures of retina and choroidea in the early stages of alloxan-induced diabetes显示文摘AIM To investigate the temporal sequence of pathological changes in the cellular structures of retina and choroidea in the early stages of diabetes in laboratory animals.METHODS Experimental type 1 diabetes was modeled by three intraperitoneal injections of an alloxan solution into 30 male nonlinear rats at 16 wk of age. The 30 th and 60 th days from the final alloxan injection were chosen as the endpoints. Light and electron microscopy and morphometric and immunohistochemical studies were performed on histological slices of eyeballs from experimental animals.RESULTS Diabetic disturbances progressed to 60 d of the experiment. Thus, in the retina, a partial destruction of photoreceptors accompanied by interstitial edema was observed. The morphometric analysis revealed a reduction in the thickness of the retina. A reduction in the number of blood vessels of the choroid with disturbances of the endothelial cells and the vascular walls and a persistent reduction in the number of melanocytes were observed. The number of proliferating Ki-67 positive cells decreased, and the number of macrophages increased with diabetes development.CONCLUSION The starting point in the development of destructive changes involves early reduction in the number of melanocytes of the choroidea and alterations in the retinal pigment epithelium. | Irina Danilova Svetlana Medvedeva Svetlana Shmakova Margarita Chereshneva Alexey Sarapultsev Petr Sarapultsev | 2018 | World Journal of Diabetes2018，9，12： | 6 |
| 19 | 抗菌型鞋衬里革的制备及抗菌性能研究显示文摘使用一种新的抗菌剂——4-(2-苯并噻唑基亚氨甲基)苯氧乙酸的铜配合物(简称CCBMP),以喷洒的方式加入到鞋衬里革中,并采用抑菌圈法和抑菌率法测定了鞋衬里革对从鞋内分离出来的霉菌、细菌和酵母菌的抑制效果,结果表明:当该化合物在鞋衬里革中的含量为18.68g/kg时,鞋衬里革对混合细菌、混合霉菌和混合酵母菌的抑菌率,分别为99.83%、99.98%和99.99%,而要形成清晰的抑菌圈,它在鞋衬里革中的含量则要到达37.59g/kg。 | 辜海彬 赵长青 陈武勇 郝霞 Petr Hlavek | 2009 | 中国皮革2009，38，5： | 6 |
| 20 | Influence of chamber misalignment on cased telescoped(CT) ammunition accuracy显示文摘As part of a research program, it was desired to better understand the impact of the rotating chamber alignment with the barrel throat on the precision and accuracy of a novel cased telescoped(CT) ammunition firing rifle. In order to perform the study, a baseline CT ammunition chamber which was concentric with a Mann barrel bore was manufactured. Additionally, six chambers were manufactured with an offset relative to the barrel bore. These chambers were used to simulate a misaligned chamber relative to the bore axis. Precision and accuracy tests were then performed at 200 m in an indoor range under controlled conditions. For this project, 5.56 mm CT ammunition was used. As the chamber axis offset relative to the gun bore was increased, the mean point of impact was displaced away from the target center. The shift in the impact location is explained by the presence of in-bore yaw which results in lateral throw-off and aerodynamic jump components. The linear theory of ballistics is used to establish a relationship between the chamber misalignment and the resulting projectile mean point of impact for a rifle developed to fire CT ammunition. This relationship allows for the prediction of the mean point of impact given a chamber misalignment. | D.CORRIVEAU C.FLORIN PETRE | 2016 | Defence Technology(防务技术)2016，12，2： | 6 |
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