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| 1 | Clinical correlation of gallstone disease in a Chinese population in Taiwan:Experience at Cheng Hsin General Hospital显示文摘瞄准:在与它有关的台湾和联系条件的因素探索胆石疾病(GSD ) 的流行。方法:我们自愿地学习了 2386 个健康成年人(1235 男性和 1151 女性) 的一个总数为在 2002 年 1 月和 2002 年 12 月之间的付的物理检查承认了到 Cheng Hsin 医院将军。血样品和超声 sonography 结果是镇定的。结果:在这张学习人口之中的 GSD 的全面流行是 5.3% ,包括 1.7%(n=40 ) 有一块单个石头, 2.3%(n=55 ) 有多重石头,并且 1.3%(n=31 ) 有胆囊炎。流行与增加年龄(P<0.0001 ) 揭示了统计上重要的增加。女性们比展出了多重石头的更大的流行做了男性(3.0% 对 1.7% , P=0.04 ) 。用多重逻辑回归分析,下列看起来是显著地与 GSD 的流行有关:老年(40-49 年对 <
40 年, OR=1.63 [95% CI:0.76-3.48 ] , 50-59 年对 <
40 年, OR=4.93 [95% CI:2.43-9.99 ] , 60-69 年对 <
40 年, OR=6.82 [95% CI:3.19-14.60 ] , >
或 = 70 年对 <
40 年, OR=10.65 [95% CI:4.78-23.73 ]) ,更高的 BMI (>
或 = 27 kg/m2 对 <
24 kg/m2,调整 OR=1.74 [95% CI:1.04-2.88 ]) ,并且更高的 FPG (>
或 = 126 mg/dL 对 <
110 mg/dL, OR=1.71, 95%CI:1.01-2.96 ) 。结论:老年(>
或 = 50 年) ,肥胖(BMI >
或 = 27 kg/m2 ) ,并且类型 2 糖尿病(FPG >
或 = 126 mg/dL ) 与 GSD 的流行被联系。 | Chi-Ming Liu Tao-Hsin Tung Pesus Chou Victor Tze-Kai Chen Chung-Te Hsu Wu-Shyong Chien Yeu-Tyng Lin Hsu-Feng Lu Hui-Chuan Shih Jorn-Hon Liu | 2006 | World Journal of Gastroenterology2006，12，8： | 11 |
| 2 | Long-term efficacy and safety of very-low-dose amiodarone treatment for the maintenance of sinus rhythm in patients with chronic atrial fibrillation after successful direct-current cardioversion显示文摘Background Long-term maintenance of sinus rhythm after successful conversion of chronic atrial fibrillation(CAF),often ameliorates patients’ symptoms,reduces the risk of ischemic stroke and improves cardiovascular hemodynamics.This prospective study aims to evaluate the long-term efficacy and safety of very low-dose amiodarone(100 mg daily) for the maintenance of sinus rhythm after successful direct-current(DC) cardioversion in patients with CAF and rheumatic heart disease(RHD) post intervention.Methods This study was a randomized prospective trial.One day after successful DC cardioversion(remained normal sinus rhythm) in patients with CAF and RHD post intervention for more than six months and adequate anticoagulation,all were randomly administered either amiodarone 200 mg daily in group A or amiodarone 100 mg daily in group B.Results A total of 76 patients(40 men and 36 women) were examined from February 1998 to December 1999.The mean age of the patients was(66±10) years,and the mean follow-up was(67±8) months(range 61 to 84 months).Actuarial rates of the maintenance of sinus rhythm were similar in the two groups after 5 years of follow-up.Four patients(11 %) in group A but none in group B experienced significant adverse effects that necessitated withdrawal of amiodarone.No death occurred during the study period.Conclusion A very low dose of amiodarone results in adequate long-term efficacy and is safe for maintaining sinus rhythm in patients with CAF and RHD post intervention after successful DC cardioversion. | JONG Gwo-ping, CHANG Mu-hsin, CHANG Ting-chuan, CHOU Pesus, FU Chong-yau, TIEN Li-yun,CHEN Chung-yin and MA Tso-chiang JONG Gwo-ping CHANG Mu-hsin CHANG Ting-chuan CHOU Pesus FU Chong-yau TIEN Li-yun CHEN Chung-yin MA Tso-chiang | 2006 | Chinese Medical Journal2006，，24： | 6 |
| 3 | A population-based follow-up study on gallstone disease among type 2 diabetics in Kinmen,Taiwan显示文摘瞄准:估计发生并且在 Kinmen 在类型 2 糖尿病患者之中为胆石疾病(GSD ) 冒因素的风险,台湾。方法:为 GSD 的一个屏蔽节目被采用了即时腹的超声在病人们有 fasted 至少八个小时以后,检验腹的区域的二位专家执行。屏蔽,它在 2001 被进行,包含了与类型 2 糖尿病诊断的 848 个病人。在有流行 GSD 的 63 个题目的排除以后,没有 GSD 的 377 个参加者为秒轮屏蔽在 2002 被邀请。281 的一个总数(74.5%) 使遭到是 re-examined。结果:在 281 类型之中没在首先屏蔽有 GSD 的 2 名糖尿病患者, 10 在 2002 开发了 GSD。发生每年是 3.56%(95% CI:1.78% 每 year-6.24% 每年) 。用一个考克斯回归模型,变老(RR = 1.07, 95% CI:1.00-1.14 ) ,腰圆周(RR = 1.12, 95% CI:1.01-1.29 ) ,并且中高音(RR = 1.13, 95%CI:1.01-1.26 ) 看起来显著地与 GSD 的开发被相关。结论:老年是为 GSD 的发展的一个已知的风险因素。我们那更大的腰圆周和提高的中高音铺平的学习表演也在 Kinmen 在类型 2 糖尿病患者之中与 GSD 的发展被联系。 | Tao-Hsin Tung Hsiao-Man Ho Hui-Chuan Shih Pesus Chou Jorn-Hon Liu Victor TK Chen De-Chuan Chan Chi-Ming Liu | 2006 | World Journal of Gastroenterology2006，12，28： | 6 |
| 4 | Serum insulin, insulin resistance, p-cell dysfunction, and gallstone disease among type 2 diabetics in Chinese population: A community-based study in Kinmen, Taiwan显示文摘AIM: To explore the association of serum insulin, insulin resistance, and β-cell dysfunction with gallstone disease (GSD) in type 2 diabetics. METHODS: We used a community-based study conducted between 1991 and 1993 in Kinmen, Taiwan to identify type 2 diabetics. A screening program for GSD was performed in 2001 by a panel of specialists who employed real-time ultrasound sonography to examine the abdominal region after the patient had fasted for at least 8 h. Screening was conducted in 2001 on 848 patients diagnosed with type 2 diabetes. The HOMA method was used to compare the profile differences for insulin resistance (HOMA IR) and β-cell dysfunction (HOMA β-cell). RESULTS: We studied 440 type 2 diabetics who attended sonography check-ups. After excluding eight insulin-treated diabetics, the prevalence of GSD among the remaining 432 was 13.9% (26/187) among males and 14.7% (36/245) among females. After adjustment for other GSD-associated risk factors in addition to age and obesity, GSD risk increased among females with levels of serum insulin [4th vs 1st quartile odds ratios (OR) = 4.46 (95%CI: 1.71-11.66)] and HOMA IR [4th vs 1st quartile OR = 4.46 (95%CI: 1.71-11.66)]. Better HOMA β-cell function was significantly related to decreased risk of GSD [4th vs 1st quartile OR = 0.16 (95%CI: 0.03-1.70)]. Among males, age and central obesity were the most significant risk factors for GSD. No association of GSD with serum insulin, HOMA IR, and HOMA β-cell was observed among males. CONCLUSION: Serum insulin, insulin resistance, and β-cell dysfunction are risk factors for GSD in females, but not males with type 2 diabetes. | Chi-Ming Liu Tao-Hsin Tung Shih-Tzer Tsai Jorn-Hon Liu Yeh-Kuang Tsai Victor Tze-Kai Chen Tseng-Nip Tam Hsu-Feng Lu Kuang-Kuo Wang Chung-Te Hsu Hui-Chuan Shih De-Chuan Chan Pesus Chou | 2005 | World Journal of Gastroenterology2005，11，45： | 2 |
| 5 | Prevalence of dry eye among an elderly Chinese population in Taiwan显示文摘 | Pei-Yu Lin Su-Ying Tsai Ching-Yu Cheng Jorn-Hon Liu Pesus Chou Wen-Ming Hsu | 2003 | Ophthalmology2003，，6： | 2 |
| 6 | T - cell - expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance显示文摘 | Pesu M Wafford WT Wei L | 2008 | Nature2008，455，7210： | 1 |
| 7 | The Janus kinases (Jaks) 显示文摘 | Yamaoka K Saharinen P Pesu M Holt VE 3rd Sil- vennoinen O O' Shea JJ | 2004 | Genome Biol2004，5，12： | 1 |
| 8 | Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase Ⅱ显示文摘 | YANG J AITTOMAKI S PESU M | 2002 | EMBO J2002，21，18： | 1 |
| 9 | CD4 + Foxp3 + regulatory Tcells confer infectious tolerance in a TGF-beta-dependent manner显示文摘 | Andersson J Tran DQ Pesu M | 2008 | J Exp Med2008，205，9： | 1 |
| 10 | The Janus kinases (Jaks)显示文摘 | Yamaok K Saharinen P Pesu M | 2004 | Genome Biol2004，5，12： | 1 |
| 11 | Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase Ⅱ显示文摘 | Yang J Ahtomaki S Pesu M | 2002 | EMBO2002，21，18： | 1 |
| 12 | Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II显示文摘 | YANG AITTOM(A)KI S PESU M | | 0，，18： | 1 |
| 13 | A new modali- ty for immunesuppression, targeting the JAK/ STAT pathway显示文摘 | O'Shea J j Pesu M Borie D C etal | 2004 | Nat Rev Drug Discov2004，3，： | 1 |
| 14 | Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon- γ 显示文摘 | Pesu M Muul L Kanno Y | 2006 | Blood2006，108，3： | 1 |
| 15 | Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase Ⅱ显示文摘 | Yang J Aittomaki S Pesu M | 2002 | EMBO J2002，21，18： | 1 |
| 16 | Relative role of insulin resistance and β-cell dysfunction in the progression to type 2 diabetes—The Kinmen Study显示文摘 | Chia-Lin Li Shih-Tzer Tsai Pesus Chou | 2002 | Diabetes Research and Clinical Practice2002，，3： | 1 |
| 17 | Therapeutic targeting of the JAK/STAT pathway 显示文摘 | Aittomaki S Pesu M | 2014 | Basic Clin Pharmacol Toxicol2014，114，1： | 1 |
| 18 | Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase Ⅱ显示文摘 | YANG J AITTOM KIi S PESU M | 2002 | EMBO J2002，21，18： | 1 |
| 19 | Jak3, severe combined immunodeficiency,and a new class of immunosuppressive drugs显示文摘 | Pesu M Candotti F Husa M | 2005 | Immunol Rev2005，203，： | 1 |
| 20 | T cell-expressed propor- tion eonvertase furin is essential for maintenance of peripheral tolerance显示文摘 | Pesu M Warlord WT Wei L etal | 2008 | Nature2008，455，： | 1 |
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