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| 1 | 炎症、癫痫发作和癫痫发生:对人类疾病的探索显示文摘癫痫在历史上被认为是一种神经元信号异常传导的疾病,表现为癫痫发作。随着大量自身抗体的发现和对自身免疫性脑炎认识的不断加深,人们越来越重视先天性和适应性免疫系统在癫痫发作和癫痫发生中的作用。在不同的癫痫发作相关的神经炎症和自身免疫疾病中,不同程度观察到了致病性抗体、补体激活、CD8+细胞毒性T细胞和小胶质细胞激活。这些异常的免疫反应被认为会导致神经元信号传导破坏,产生急性症状性癫痫发作,并且在某些情况下,还会发展为长期的自身免疫性癫痫。虽然早期使用免疫调节疗法可以改善自身免疫性脑炎和自身免疫性癫痫的预后,但患者的识别和治疗方法的选择并不总是明确。本篇综述讨论了免疫系统的不同成分在各种形式的癫痫发作中的作用,包括自身免疫性脑炎、自身免疫性癫痫、Rasmussen脑炎、热性感染相关性癫痫综合征和新发难治性癫痫持续状态。尤其是讨论了在这些疾病中观察到的病理生理学和独特的细胞因子谱,及其与诊断、预后和治疗决策的联系。 | Tan TH Perucca P O'Brien TJ Kwan P 高凡凯(译) 李硕(译) 薛国芳(审) Mastura Monif | 2022 | 癫痫杂志2022，8，4： | 2 |
| 2 | Sex difference in urine concentration across differing age,sodium intake,and level of kidney disease显示文摘 | Perucca J Bouby N Valeix P | 2007 | Am J Physiol Regul Integr Comp Physiol2007，292，： | 1 |
| 3 | Clinically important drug interactions in epilepsy:general features and interactions between antiepileptic drugs显示文摘 | PATSALOS P N PERUCCA E | 2003 | Lancet Neurol2003，2，6： | 1 |
| 4 | Adverse Antiepileptic Drug Effects:Toward A Clinically and Neurobiologically Relevant Taxonomy显示文摘 | Perucca P Carter J Vahle V | 2009 | Neurology(S0028-3878)2009，72，14： | 1 |
| 5 | Clinically important drug interactions in epilepsy:interactions between antiepileptic drugs and other drugs显示文摘 | PATSALOS P N PERUCCA E | 2003 | Lancet Neurol2003，2，8： | 1 |
| 6 | Epilepsy:new advances显示文摘 | Moshe SL Perucca E Ryvlin P | 2015 | Lancet2015，385，9971： | 1 |
| 7 | High-frequency oscillations,extent of surgical resection,and surgical outcome in drug-resistant focal epilepsy显示文摘 | Haegelen C Perucca P Chatillon C E | 2013 | Epilepsia2013，54，5： | 1 |
| 8 | P21 does not interfere with loading of PCNA at DNA replication sites, but inhibits subsequent bind- ing of DNA polymerase delta at the G1/S phase transition显示文摘 | Cazzalini O Perucca P Nishida M | 2003 | Cell Cycle2003，2，6： | 1 |
| 9 | Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy 显示文摘 | Brodie MJ Perucca E Ryvlin P Ben-Menachem E Meencke HJ | 2007 | Neurology2007，68，6： | 1 |
| 10 | High-frequency oscillations, extent of surgical resection, and surgical outcome in drag-resistant focal epilepsy 显示文摘 | Haegelen C Perucca P Chatillon CE | 2013 | Epilepsia2013，54，5： | 1 |
| 11 | High-frequency oscillations, extent of surgical resection, and surgical outcome in drag-resistant focal epilepsy 显示文摘 | Haegelen C Perucca P Chatillon CE | 2013 | Epilepsia2013，54，5： | 1 |
| 12 | Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs 显示文摘 | PATSALOS P N PERUCCA E | 2003 | Lancet Neurol2003，2，8： | 1 |
| 13 | Adverse effects of antiepileptic drugs显示文摘 | PERUCCA P GILLIAM F G | 2012 | Lancet Neurol2012，11，9： | 1 |
| 14 | Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy 显示文摘 | Brodie MJ Perucca E Ryvlin P | 2007 | Neurology2007，68，： | 1 |
| 15 | Intracellular localization of the cyclin-dependent kinase inhibitor p21CDKN1A-GFP fusion protein during cell cycle arrest显示文摘 | Cazzalini O Perucca P Valsecchi F | 2004 | Histochem Cell Biol2004，121，5： | 1 |
| 16 | Comparisonof levetiracetam and controlled - release carbamazepinein newly diagnosed epilepsy 显示文摘 | Brodie MJ Perucca E Ryvlin P | 2007 | Neurology2007，68，： | 1 |
| 17 | The adverse event profile of pregabalin:a systematic review and meta-analysis of randomized controlled trials显示文摘 | Zaccara G Gangemi P Perucca P | 2011 | Epilepsia2011，52，4： | 1 |
| 18 | Genetic basis for idiosyn-cratic reactions to antiepileptic drugs显示文摘 | Franciotta D Kwan P Perucca E | 2009 | Curr Opin Neurol2009，22，12： | 1 |
| 19 | Sex difference in urine concentration across differing ages, sodium intake, and level of kidney dis-ease 显示文摘 | PERUCCA J BOUBY N VALEIX P | 2007 | Am J Physiol Regul Integr Comp Physiol2007，292，2： | 1 |
| 20 | Overtreatment in epilepsy:how it occurs and how it can be avoided显示文摘 | Perucca E Kwan P | 2005 | CNC Drugs2005，19，11： | 1 |
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