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| 1 | Mechanical thrombectomy in patients with M1 occlusion and NIHSS score≤5:a single-centre experience显示文摘Background:The recent success of several mechanical thrombectomy trials has resulted in a significant change in management for patients presenting with stroke.However,it is still unclear how to manage patients that present with stroke and low National Institutes of Health Stroke Scale(NIHSS)≤5.We sought to review our experience of mechanical thrombectomy in patients with low NIHSS and confirmed M1 occlusion.Methods:We retrospectively analysed our prospectively maintained database of all patients undergoing mechanical thrombectomy between January 2008 and August 2016.We identified 41 patients with confirmed M1 occlusion and low NIHSS(≤5)on admission to our hospital.We collected demographic,radiological,procedural and outcome data.Results:The mean age of patients was 72±14,with 20 male patients.Associated medical conditions were common with hypertension seen in∼80%.Just over 50%presented with NIHSS 4 or 5.The average ASPECTS score on admission was 8.8(range 6–10),and the average clot length 10 mm.Angiographically Thrombolysis in Cerebral Infarction(TICI)≥2b was obtained in 87.8%of patients.7 patients had haemorrhage on follow-up,2 of which were symptomatic.Of 40 patients with 90-day follow-up,75%had modified Rankin Scale(mRS)score 0–2.There were 3 deaths at 90 days.Conclusions:Mechanical thrombectomy in patients with low NIHSS and proximal large vessel occlusion is technically possible and carries a high degree of success with good safety profile.Patients with low NIHSS and confirmed occlusion should be considered for mechanical thrombectomy. | P Bhogal P Bucke O Ganslandt H Bazner H Henkes M Aguilar Perez | 2016 | Stroke & Vascular Neurology2016，1，4： | 9 |
| 2 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 3 | Selectively permeable dendrimers as molecular gates显示文摘 | Gregory P Perez Richard M Crooks | 2001 | Interface2001，10，： | 2 |
| 4 | p75 Co-receptors regulate ligand-dependent and ligand-independent Trk receptor activation, in part by altering Trk docking subdomains 显示文摘 | Zaccaro MC Ivanisevic L Perez P | 2001 | Journal of Biological Chemistry2001，276，31： | 2 |
| 5 | Eicosapentaenoic acid actions on adiposity and insulin resistance in control and high - fat - fed rats : Role of apoptosis, adiponectin and tumour necrosis factor - alpha 显示文摘 | Perez - Matute P Perez - Echarfi N Martinez JA | 2007 | Br J Nutr2007，97，2： | 1 |
| 6 | Cytotoxic constituents from daphnia pulex 显示文摘 | Perez Gutierrez R M Lule P R | 2005 | Pharmaceutical Biology2005，43，4： | 1 |
| 7 | Coloring of titanium through laser oxidation: Comparative study with anodizing 显示文摘 | Perez Del P Ferndndez-Pradas J M Serra P | 2004 | Surface and Coatings Technology2004，187，1： | 1 |
| 8 | Suppression of performance curve instability of an axial-flow pump by using a double-inlet-nozzle 显示文摘 | Perez Flores P Kosyna G Wulff D | 2008 | International Journal of Rotating Machinery2008，，53： | 1 |
| 9 | Radiation therapy morbidity in carcinoma of the uterine cervix: Dosimetric and clinical correlation显示文摘 | PEREZ C A GRIGSBY P W LOCKETr M A | 1999 | Int J Radiat Oncol Biol Phys1999，44，4： | 1 |
| 10 | Data fusion for trackingwith particles显示文摘 | Perez P Vermaak J Blake A | 2004 | the IEEE2004，92，3： | 1 |
| 11 | Identification of aphid (Homoptera:Aphididae) species and clones by random amplification polymorphic DNA显示文摘 | CENIS J L PEREZ P FERERES A | 1993 | Annals of the Entomological Sciety of America1993，86，5： | 1 |
| 12 | A novel p75 neurotrophin receptor-related protein,NRH2,regulates nerve growth factor binding to the TrkA receptor显示文摘 | MURRAY S S PEREZ P LEE R | 2004 | J Neurosci2004，24，11： | 1 |
| 13 | 显示文摘 | Garcia Sanchez MV Lopez Vallejos P Perez deLuque D | 2004 | Rev Esp Enferm Dig2004，96，5： | 1 |
| 14 | Clinical trials: healing of erosive oesophagitis with dexlansoprazole MR, aproton pump inhibi-tor with a novel dual delayed release formulation - results from two randomized controlled studies 显示文摘 | Sharma P Shaheen NJ Perez MC | 2009 | Aliment Pharmacol Ther2009，29，： | 1 |
| 15 | Approaching the useof oscillating reactions for analytical monitoring显示文摘 | Jimenez P R Silva M Perez B D | 1998 | Analyst1998，123，2： | 1 |
| 16 | Security model applied to electronic records management: experiences and results in the nuclear sector显示文摘 | Solana P Perez D | 2011 | International Journal of Technology Management2011，54，2： | 1 |
| 17 | The development of university spin-offs:early dynamics of technology transfer and net- working显示文摘 | PEREZ M P SANCHEZ A M | 2003 | Technovation2003，23，10： | 1 |
| 18 | Region filling and object removal by exemplar-based image inpainting 显示文摘 | Criminisi A Perez P Toyama K | 2004 | IEEE Transactions on Image Processing2004，13，9： | 1 |
| 19 | Biosynthesis of strawberry aroma compounds through amino acid metabolism显示文摘 | Perez A G Olias R Luaces P Sanz C | 2002 | Journal of Agricultural and Food Chemistry2002，50，14： | 1 |
| 20 | Poisson Image Editing显示文摘 | PEREZ P GANGNET M BLAKE A | 2003 | ACM Transactions on Graphics-Proceedings of Acm Siggraph2003，22，3： | 1 |
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