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| 1 | Prognosis of cognition in congenital hypothyroidism following early treatment显示文摘 | ALVAREZ GMA CARVAJAL MF PEREZ GC | 2004 | Rev Neurol2004，38，6： | 1 |
| 2 | Effect of triterpe- noids of bouvardia terniflora on blood sugar levels of nor- mal and alloxan diabetic mice显示文摘 | Perez GRM Perez GC Perez GS | 1998 | Phytomedicine1998，5，6： | 1 |
| 3 | Effect of triterpenoids of Bouvardin temiflora on blood sugar levels of nor- mal and alloxan diabetic mice 显示文摘 | Perez GRM Perez GC Perez GS | 1998 | Phytomedicine1998，5，6： | 1 |
| 4 | Effect of triterponoids of Bouvardia terniflora on blood sugar levels of normal and alloxan diabetic mice显示文摘 | Perez GRM Perez GC Perez GS | 1998 | Phytomedicine1998，5，6： | 1 |
| 5 | LFA-1 signaling through p44/42 is coupled to perforin degranulation in CD56 CD8+ natural killer cells显示文摘 | Perez OD Mitehell D Jager GC | 2004 | Blood2004，104，4： | 1 |
| 6 | Antifungal activity of seselin in protecting stored maize from Aspergillusflavus 显示文摘 | Cardenas ONC Perez GC Perez GS | 2007 | Asian J Plant Sci2007，6，： | 1 |
| 7 | A review onthe dietary flavonoid kaempferol显示文摘 | Calderon-Monta-o JM Burgos ME Perez GC | 2011 | Mini Rev Med Chem2011，11，4： | 1 |
| 8 | Prospective application of a bleeding and ischemic risks-adjusted antithrombotic protocol in elderly patients revascularized with everolimus-eluting stents:EPIC05-Sierra75 study显示文摘OBJECTIVES Elderly patients show a higher incidence of ischemic and bleeding events after percutaneous transluminal coron-ary intervention(PCI).We sought to investigate outcomes in elderly patients treated with antithrombotic strategy guided by bleeding and ischemic risks after revascularization with last generation everolimus-eluting stent(EES).METHODS Prospective multicenter registry including patients over 75 years revascularized with EES and antithrombotic ther-apy guided by clinical presentation,PCI complexity and PRECISE DAPT score.Co-primary safety endpoints were:(1)composite of cardiac death,myocardial infarction and stent thrombosis and;(2)bleeding(BARC 2-5).Primary efficacy endpoint was target lesion revascularization.A matched group of patients revascularized with current drug-eluting stents and no such tailored antith-rombotic therapy was used as control.RESULTS Finally,1064 patients were included in SIERRA-75 cohort,80.8±4.2 years,36.6%women,71%acute coronary syn-dromes(ACS)and 53.6%complex PCI.Co-primary safety endpoint of major adverse cardiovascular events was met in 6.2%,co-primary safety endpoint of bleeding in 7.8%and primary efficacy endpoint of TKLR in 1.5%.The multivariable adjusted model showed no significant association of the prescribed short/long dual antiplatelet therapy(DAPT)durations with any endpoint suggesting a well tailored therapy.No stent thrombosis reported in the subgroup with 1-3 months DAPT duration.As compared to control group,bleeding BARC 2-5 was significantly lower in SIERRA-75 group(7.4%vs.10.2%,P=0.04)as well as the net safety-efficacy endpoint(14.3%vs.18.5%,P=0.02).CONCLUSIONS In elderly population,the application of this risks-adjusted antithrombotic protocol after revascularization with last generation EES seems to be associated with an improved prognosis in terms of ischemic and bleeding outcomes. | Jose M de la Torre Hernandez Ramon Lopez Palop Jesus M Jimenez Mazuecos Pilar Carrillo Sáez Alejandro Gutierez-Barrios Eduardo Pinar Belen Cid Luis Fernandez Tamara Garcia Camarero Cristóbal Urbano-Carrillo Juan F Oteo Dominguez Victor A Jimenez Diaz Antonio EGomez Menchero Eladio Galindo Fernández Juan GCórdoba Soriano Raymundo Ocaranza Eduardo ArroyoÚcar Koldobika Garcia San Roman Silvio Leal Ginés Martínez Cáceres Jose A Linares Vicente Georgina Fuertes Ferre Xavier Carrillo Juan CRama Merchán Catia Costa Juan Sanchis Renato Fernandes Alberto Rodrigues Jose M Vegas Valle Hélder Pereira Armando Perez de Prado | 2022 | Journal of Geriatric Cardiology2022，19，5： | 0 |
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