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| 1 | Role of antibiotics for treatment of inflammatory boweldisease显示文摘Inflammatory bowel disease is thought to be caused by an aberrant immune response to gut bacteria in a genetically susceptible host. The gut microbiota plays an important role in the pathogenesis and complications of the two main inflammatory bowel diseases: Crohn's disease(CD) and ulcerative colitis. Alterations in gut microbiota, and specifically reduced intestinal microbial diversity, have been found to be associated with chronic gut inflammation in these disorders. Specific bacterial pathogens, such as virulent Escherichia coli strains, Bacteroides spp, and Mycobacterium avium subspecies paratuberculosis, have been linked to the pathogenesis of inflammatory bowel disease. Antibiotics may influence the course of these diseases by decreasing concentrations of bacteria in the gut lumen and altering the composition of intestinal microbiota. Different antibiotics, including ciprofloxacin, metronidazole, the combination of both, rifaximin, and anti-tuberculous regimens have been evaluated in clinical trials for the treatment of inflammatory bowel disease. For the treatment of active luminal CD, antibiotics may have a modest effect in decreasing disease activity and achieving remission, and are more effective in patients with disease involving the colon. Rifamixin, a non absorbable rifamycin has shown promising results. Treatment of suppurative complications of CD such as abscesses and fistulas, includes drainage and antibiotic therapy, most often ciprofloxacin, metronidazole, or a combination of both. Antibiotics might also play a role in maintenance of remission and prevention of post operative recurrence of CD. Data is more sparse for ulcerative colitis, and mostly consists of small trials evaluating ciprofloxacin, metronidazole and rifaximin. Most trials did not show a benefit for the treatment of active ulcerative colitis with antibiotics, though 2 meta-analyses concluded that antibiotic therapy is associated with a modest improvement in clinical symptoms. Antibiotics show a clinical benefit when used for the treatment of pouchitis. The downsides of antibiotic treatment, especially with recurrent or prolonged courses such as used in inflammatory bowel disease, are significant side effects that often cause intolerance to treatment, Clostridium dificile infection, and increasing antibiotic resistance. More studies are needed to define the exact role of antibiotics in inflammatory bowel diseases. | Orna Nitzan Mazen Elias Avi Peretz Walid Saliba | 2016 | World Journal of Gastroenterology2016，22，3： | 14 |
| 2 | Factors associated with time to laparoscopic cholecystectomy for acute cholecystitis显示文摘AIM: To determine patient and process of care factors associated with performance of timely laparoscopic cholecystectomy for acute cholecystitis. METHODS: A retrospective medical record review of 88 consecutive patients with acute cholecystitis was conducted. Data collected included demographic data, co-morbidities, symptoms and physical findings at presentation, laboratory and radiological investigations, length of stay, complications, and admission service (medical or surgical). Patients not undergoing cholecystectomy during this hospitalization were excluded from analysis. Hierarchical generalized linear models were constructed to assess the association of pre-operative diagnostic procedures, presenting signs, and admitting service with time to surgery.RESULTS: Seventy cases met inclusion and exclusion criteria, among which 12 were admitted to the medical service and 58 to the surgical service. Mean ± SD time to surgery was 39.3 ± 43 h, with 87% of operations performed within 72 h of hospital arrival. In the adjusted models, longer time to surgery was associated with number of diagnostic studies and endoscopic retrograde cholangio-pancreatography (ERCP, P = 0.01) as well with admission to medical service without adjustment for ERCP (P < 0.05). Patients undergoing both magnetic resonance cholangiopancreatography (MRCP) and computed tomography (CT) scans experienced the longest waits for surgery. Patients admitted to the surgical versus medical service underwent surgery earlier (30.4 ± 34.9 vs 82.7 ± 55.1 h, P < 0.01), had less post-operative complications (12% vs 58%, P < 0.01), and shorter length of stay (4.3 ± 3.4 vs 8.1 ± 5.2 d, P < 0.01).CONCLUSION: Admission to the medical service and performance of numerous diagnostic procedures, ERCP, or MRCP combined with CT scan were associated with longer time to surgery. Expeditious performance of ERCP and MRCP and admission of medically stable patients with suspected cholecystitis to the surgical service to speed up time to surgery should be considered. | Chris N Daniak David Peretz Jonathan M Fine Yun Wang Alan K Meinke William B Hale | 2008 | World Journal of Gastroenterology2008，14，7： | 13 |
| 3 | Association of Streptococcus bovis presence in colonic content with advanced colonic lesion显示文摘AIM:To prospectively examine the association between presence of Streptococcus bovis(S.bovis)in colonic suction fluid and the endoscopic findings on colonoscopy.METHODS:From May 2012 to March 2013,203 consecutivepatients who underwent colonoscopy for any reason were enrolled in the study.Exclusion criteria included:antibiotic use in the previous month,age younger than18 years,and inadequate preparation for colonoscopy.The colonoscopy was performed for the total length of the colon or to the occluding tumor.The endoscopic findings were registered.Samples were obtained proximal to the colonoscopic part of the suction tube from each patient and sent to the clinical microbiology laboratory for isolation and identification of S.bovis.Samples were incubated in enrichment media with addition of antibiotic disks for inhibition of growth of Gram-negative rods.The samples were seeded on differential growth media;suspected positive colonies were isolated and identified with Gram staining,catalase,and pyrrolidonyl arylamidase tests,and further identified using a VITEK2 system.Statistical analyses were performed using the Student’s t andχ2 tests.RESULTS:Of the 203 patients recruited,49(24%)patients were found to be S.bovis carriers;of them,the endoscopic findings included:17(34.7%)cases with malignant tumors,11(22.4%)with large polyps,5(10.2%)with medium-sized polyps,6(12.2%)with small polyps,4(8.1%)with colitis,and 6(12.2%)normal colonoscopies.Of 154 patients found negative for S.bovis,the endoscopic findings included:none with malignant tumors,9(5.8%)cases with large polyps,11(7.1%)with medium-sized polyps,26(16.9%)with small polyps,7(4.5%)with colitis,and101(65.6%)normal colonoscopies.S.bovis(Grampositive coccus)is considered part of the normal intestinal flora.There is an association between S.bovis bacteremia and colonic neoplasia.It is not well understood whether the bacterium has a pathogenetic role in the development of neoplasia or constitutes an epiphenomenon of colorectal neoplasms.There was a clear relationship between positivity for S.bovis in colonic suction fluid and findings of malignant tumors and large polyps in the colon.CONCLUSION:There is an association between S.bovis bacteremia and malignant colonic lesions;this should prompt for development of a reliable screening method for advanced colonic lesions. | Maya Paritsky Nina Pastukh Diana Brodsky Natalya Isakovich Avi Peretz | 2015 | World Journal of Gastroenterology2015，21，18： | 9 |
| 4 | Mechanisms underlying the cardiac pacemaker: the role of SK4 calcium-activated potassium channels显示文摘心脏的心律调整器的合适的表示和功能是心生理学的一个批评特征。在人权中庭的 sinoatrial 节点(圣) 每分钟产生电的刺激约 70 次,它从一个传导性的网络宣传到在收缩期间导致房间收缩的心肌层。尽管 SAN 和另外的节的传导性的结构超过一个世纪以前被识别,涉及心脏的自动性的产生的机制仍然保持高度辩论了。在这短评论,我们调查与人的心脏的传导系统和被建议了位于心律调整器活动下面的各种各样的机制的开发有关的当前的数据。我们也介绍人的胚胎的茎导出房间的 cardiomyocyte 系统,它作为一个模型被使用学习心律调整器。最后,我们在心律调整器房间描述我们 SK4 Ca 2+-activated K + 隧道传导力的以前未被认出的角色的最近的描述。由精致地在心脏舒张的去极期间平衡里面的水流, SK4 隧道看起来在人的心脏的自动性起一个关键作用。 | David WEISBROD Shiraz Haron KHUN Hanna BUENO Asher PERETZ Bernard ATTALI | 2016 | Acta Pharmacologica Sinica2016，37，1： | 4 |
| 5 | Late onset fulminant Wilson's disease:A case report and review of the literature显示文摘Wilson’s disease(WD)is an autosomal recessive inherited disorder of hepatic copper metabolism.WD can be present in different clinical conditions,with the most common ones being liver disease and neuropsychiatric disturbances.Most cases present symptoms at<40years of age.However,few reports exist in the literature on patients in whom the disease presented beyond this age.In this report,we present a case of late onset fulminant WD in a 58-year-old patient in whom the diagnosis was established clinically,by genetic analysis of the ATP7B gene disclosing rare mutations(G1099S and c.1707+3ins T)as well as by high hepatic copper content.We also reviewed the relevant literature.The diagnosis of WD with late onset presentation is easily overlooked.The diagnostic features and the geneticbackground in patients with late onset WD are not different from those in patients with early onset WD,except for the age.Effective treatments for this disorder that can be fatal are available and will prevent or reverse many manifestations if the disease is discovered early. | Ella Weitzman Orit Pappo Peretz Weiss Moshe Frydman Yael Haviv-Yadid Ziv Ben Ari | 2014 | World Journal of Gastroenterology2014，20，46： | 2 |
| 6 | Increased fibrosis progression rates in hepatitis C patients carrying the prothrombin G20210A mutation显示文摘AIM: To examine whether hepatitis C virus (HCV)-infected patients who carry hypercoagulable mutationssuffer from increased rates of liver fi brosis. METHODS: We analyzed DNA samples of 168 HCV patients for three common hypercoagulable gene mutations: prothrombin 20210 (PT20210), factor V Leiden (FV Leiden) and methylene tetrahydrofolate reductase (MTHFR). The patients were consecutively recruited as part of the prospective 'Fibroscore Study' in France. The effect of the various mutations on the rate of fi-brosis was analyzed statistically and was correlated with epidemiological, clinical and biochemical data such as grade and stage of liver biopsies, patients' risk factors for liver cirrhosis, and timing of infection. RESULTS: Fifty two of the patients were categorized as 'fast fi brosers' and 116 as 'slow fi brosers'; 13% of the 'fast fi brosers' carried the PT20210 mutation as compared with 5.5% of the 'slow fi brosers', with an odds ratio of 4.76 (P = 0.033; 95% CI: 1.13-19.99) for 'fast' liver fibrosis. Carriage of MTHFR or FV Leiden mutations was not associated with enhanced liver fi brosis. CONCLUSION: Carriage of the PT20210 mutation is related to an increased rate of liver fi brosis in HCV patients. | Nitsan Maharshak Philippe Halfon Varda Deutsch Hava Peretz Shlomo Berliner Sigal Fishman Shira Zelber-Sagi Uri Rozovski Moshe Leshno Ran Oren | 2011 | World Journal of Gastroenterology2011，17，45： | 2 |
| 7 | In vivo generation of dendritic cells by intramuscular codelivery of FLT3 ligand and GM-CSF plasmids 显示文摘 | Peretz Y Zhou ZF Halwani F | 2002 | Mol Ther2002，6，3： | 2 |
| 8 | Cognitive performance following endarterectomy in asymptomatic severe ca rotid stenosis显示文摘 | Aharon Peretz J Tom er R Gabrieli I | 2003 | Eur J Neurol2003，10，： | 1 |
| 9 | IGF-1 receptor expression protects against microenvironmental stress found in the solid tumor 显示文摘 | Peretz S Kim C Rockwell S | 2002 | Radiat Res2002，158，2： | 1 |
| 10 | CD160 and PD-1 co-expression on HIV specific CD8 T cells defines a subset with advanced dysfunction显示文摘 | Peretz Y He Z Sbi Y | 2012 | PLoS Pathog2012，8，10： | 1 |
| 11 | Regression-rate and heat-transfer correlations for hybrid rocket combus- tion显示文摘 | Chiaverini M J Kuo K K Peretz A | 2001 | Journal of Propulsion and Power2001，17，1： | 1 |
| 12 | Regression-rateand heat-transfer correlations for hybrid rocket combustion显示文摘 | Chiaverini M J Kuo K K Peretz A | 2001 | Journal of Propulsion and Power2001，17，1： | 1 |
| 13 | Daily exposure to di(2-ethylhexyl)phthalate alters estrous cyclicity and accelerates primordial follicle recruitment potentially via dysregulation of the phosphatidylinositol 3-kinase signaling pathway in adult mice显示文摘 | Hannon PR Peretz J Flaws JA | 2014 | Biol Reprod2014，90，： | 1 |
| 14 | Tagging the neuronal entrainment to beat and meter 显示文摘 | Nozaradan S Peretz I Missal M | 2011 | J Neurosci2011，31，10： | 1 |
| 15 | Current concepts:sleep disturbances in the wake of traumatic events显示文摘 | Lavie Peretz | 2001 | New Engl J Med2001，345，： | 1 |
| 16 | Coupled rotor/tower aero elastic analysis of large horizontal axis wind turbines显示文摘 | WILLIAM W PERETZ F | 1980 | AIAAJ1980，18，9： | 1 |
| 17 | High humidity packag-ing extends life of easy peeler Citrus reticulata fruits显示文摘 | BEN-YEHOSHUA S PERETZ J RODOV V | 1996 | Proc Int SocCitric1996，1，： | 1 |
| 18 | Treatment of primary unresectable carcinoma of the pancreas with I-125 implantation显示文摘 | Peretz T Nori D Hilaris B | 1989 | Int J Radiat Oncol Biol Phys1989，17，5： | 1 |
| 19 | Treatment of primary unresectable carcinoma of the pancreas with 125 I implantation显示文摘 | Peretz T Nori D Hilaris B | 1989 | Int J Radial Oncol Biol Phys1989，17，： | 1 |
| 20 | BRCA1 and BRCA2 germ- line mutations and oral contraceptives : to use or not to use 显示文摘 | Grenader T Peretz T Lifchitz M | 2005 | Breast2005，14，4： | 1 |
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