维普中文期刊产品整合服务
5篇 您的检索式:作者名="PERE SERRA"
    题名 作者 年代 出处 被引量
1Urban sprawl pattern and land-use change detection in Yazd, Iran 显示文摘SAEED ZANGANEH SHAHRAKI DAVID SAURI PERE SERRA 2011Habitat International2011,35,:1
2Urban sprawl in the Mediterranean?显示文摘Bibiana Catalán David Saurí Pere Serra 2007Landscape and Urban Planning2007,,3:1
3Influence of naloxone andmethysergide on the analgesic effects of low - level laser in an ex-perimental pain model显示文摘PERES E SERRA A ASHMAWI H A 2010Rev Bras Anestesiol2010,60,3:1
4Quantification of lipolys isand lipid oxidation du ring cold storage of yogurts produced from milk trea-ted by ultra-high pressure homogenization显示文摘SERRA M T RUJILO A J PERE DA J 2008Journal of Food Engineer-ing2008,89,:1
5A T follicular helper cell origin for T regulatory type 1 cells显示文摘Chronic antigenic stimulation can trigger the differentiation of antigen-experienced CD4+T cells into T regulatory type 1(TR1)cells,a subset of interleukin-10-producing Treg cells that do not express FOxP3.The identities of the progenitor(s)and transcriptional regulators of this T-cell subset remain unclear.Here,we show that the peptide-major histocompatibility complex class Il(pMHCll)monospecific immunoregulatory T-cell pools that arise in vivo in different genetic backgrounds in response to pMHCll-coated nanoparticles(pMHCll-NPs)are invariably comprised of oligoclonal subpools of T follicular helper(TFH)and TR1 cells with a nearly identical clonotypic composition but different functional properties and transcription factor expression profles.Pseudotime analyses of scRNAseq data and multidimensional mass cytometry revealed progressive downregulation and upregulation of TFH and TR1 markers,respectively.Furthermore,pMHCIl-NPs trigger cognate TR1 cell formation in TFH cell-transfused immunodeficient hosts,and T-cell-specific deletion of Bcl6 or Irf4 blunts both the TFH expansion and TR1 formation induced by pMHCl-NPs.In contrast,deletion of Prdm1 selectively abrogates the TFH-to-TR1 conversion.Bcl6 and Prdm1 are also necessary for anti-CD3 mAbinduced TR1 formation.Thus,TFH cells can differentiate into TR1 cells in vivo,and BLIMP1 is a gatekeeper of this cellular reprogramming event.Patricia Solé Jun Yamanouchi Josep Garnica Muhammad Myn Uddin Robert Clarke Joel Moro Nahir Garabatos Shari Thiessen Mireia Ortega Santiswarup Singha Debajyoti Mondal César Fandos Julio Saez-Rodriguez Yang Yang Pau Serra Pere Santamaria 2023Cellular & Molecular Immunology2023,20,5:0
返回顶部 每页显示:
共1页 首页 上一页 第1页 下一页 末页 /1 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费