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| 1 | Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation显示文摘通过 ubiquitination 小径的 p53 蛋白质周转是在它的 transcriptional 活动的规定的重要机制;然而,很少通过 proteasome 独立的小径对 p53 周转被知道。消化机关扩大因素(Def ) 蛋白质为消化机关的发展是必要的。在 zebrafish, def 的功能的损失有选择地 upregulates p53 反应基因的表示,它提出至于是在 Def 和 p53 之间的关系的一个问题。我们这里报导 Def 是核仁的蛋白质并且 def 的功能的损失导致 p53 蛋白质的 upregulation,它令人惊讶地在 nucleoli 积累。我们的广泛的研究证明了 Def 能调停这个过程是的 p53 蛋白质和那的降级在 Calpain3 的活动独立于 proteasome 小径,却依赖,半胱氨酸朊酶。我们的调查结果定义调整 p53 的周转功能的一条新奇核仁的小径,它将在 organogenesis 和 tumorigenesis 推进我们 p53 的角色的理解。 | Ting Tao Hui Shi Yihong Guan Delai Huang Ye Chen David P Lane Jun Chen Jinrong Peng | 2013 | Cell Research2013，23，5： | 8 |
| 2 | Melatonin treatment induces chilling tolerance by regulating the contents of polyamine,γ-aminobutyric acid,and proline in cucumber fruit显示文摘The mechanism of melatonin(MT)induced chilling tolerance in harvested cucumber fruit was investigated at commercial maturity.In this study,cucumber fruits were treated with 100μmol L^(-1) MT at 4℃ and 90% relative humidity for 15 d of storage.In comparison with the control,cucumber treatment with MT resulted in reduced chilling injury(CI),decreased electrolyte leakage and enhanced firmness.The fruits treated with MT showed higher chlorophyll contents in storage conditions with suppressed chlorophyllase enzyme activity.MT treatment increased arginine decarboxylase(ADC)and ornithine decarboxylase(ODC)enzyme activities.Moreover,enhanced expression of the Cucumis sativus ADC(CsADC)and C.sativus ODC(CsODC)genes resulted in the accumulation of polyamine contents.Similarly,proline levels exhibited higher levels among treated fruits.Meanwhile,the proline synthesizing enzymes △1-pyrroline-5-carboxylate syntheses(P5CS)and ornithine aminotransferase(OAT)were significantly increased,while a catabolic enzyme of proline dehydrogenase(PDH)activity was inhibited by treatment.In addition,MT induced expression of C.sativus OAT(CsOAT)and C.sativus P5CS(CsP5CS)genes.Cucumber fruits treated with MT also exhibited higher γ-aminobutyric acid(GABA)content by enhanced GABA transaminase(GABA-T)and glutamate decarboxylase(GAD)enzyme activities and a higher C.sativus GAD(CsGAD)gene expression.To sum up,the results show that MT treatment enhanced chilling tolerance,which was associated with the regulation of polyamines,as well as proline and γ-aminobutyric acid. | Miilion P MADEBO LUO Si-ming WANG Li ZHENG Yong-hua JIN Peng | 2021 | Journal of Integrative Agriculture2021，20，11： | 6 |
| 3 | p53 isoform △113p53/△133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage显示文摘在 DNA 双海滨的 p53 的禁止的角色裂缝(DSB ) 修理对它的压制肿瘤的性质似乎矛盾。p53 isoform Δ 113p53/Δ 133p53 是反对 p53 apoptotic 的 p53 目标基因活动。然而,它在 DNA 损坏修理的功能的信息正在缺乏。这里,我们报导那 Δ 113p53 表示被 γ 强烈导致; -irradiation, 然而并非由紫外照耀或热电震疗法。惊人地, Δ 113p53 支持 DNA DSB 修理小径包括相应再结合,非相应的结束加入并且单个海滨的退火。学习 Δ 的生物意义;在支持 DNA DSB 修理的 113p53,我们产生了 zebrafish Δ 113p53 经由抄写的 M/M 异种像使活跃之物的受动器核酸酶技术并且发现异种对 γ 更敏感;照耀。人的 ortholog, Δ 133p53,被 γ 仅仅也导致;照耀和功能修理支持 DNA DSB。Δ 133p53-knockdown 房间响应 γ 在以后的阶段在 G2 阶段被逮捕;照耀由于 unrepaired DNA DSB 的高水平,它最后导致了房间老朽。而且, Δ 113p53/Δ 133p53 经由 upregulating 支持 DNA DSB 修理由到在他们的倡导者的 p53 应答的元素的一种新奇类型的绑定的修理基因 rad51, lig4 和 rad52 的抄写。我们的结果表明那 Δ 113p53/Δ 133p53 是为由阻止 apoptosis 并且支持 DNA DSB 修理禁止房间老朽的 DNA 损坏应力的一个进化地保存的支持幸存的因素。我们的数据也建议 Δ 的正式就职;在正常房间或纸巾的 133p53 表示为癌症病人提供一个重要忍耐标记给放射疗法。 | Lu Gong Hongjian Gong Xiao Pan Changqing Chang Zhao Ou Shengfan Ye Le Yin Lina Yang Ting Tao Zhenhai Zhang Cong Liu David P Lane Jinrong Peng Jun Chen | 2015 | Cell Research2015，25，3： | 4 |
| 4 | Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations显示文摘 | Tamura Y Peng P Liu K Daou M Srivastava PK | | 0，，： | 3 |
| 5 | Ly49 receptors activate angiogenic mouse DBA+ uterine natural killer cells显示文摘 | Patricia DA Lima Megan M Tu Mir Munir A Rahim Annie R Peng B Anne Croy Andrew P Makrigiannis | 2014 | Cellular & Molecular Immunology2014，11，5： | 3 |
| 6 | Preparation of stable micropatterns of gold on cell-adhesion-resistant hydrogels assisted by a hetero-bifunctional macromonomer linker显示文摘Surface patterning is very useful in biomaterial studies, yet it is not easy to prepare a micropattern with cell-adhesion contrast that is stable in a wet environment. Recently, a platform technique of transfer photolithography was invented to fabricate stable metal microarrays on the surface of a cell-adhesion resistant and mechanically biomimetic poly(ethylene glycol) hydrogel; the linker is the key chemical in such a transfer strategy. This article reports the design and synthesis of a hetero-bifunctional macromonomer linker with a thiol group at one end and an acryloyl group at the other end. The bifunctional linker was characterized by GPC and 1H NMR, and the average number of thiol groups in the bifunctional linker was detected by Ellman's reagent. The regent stability under wet conditions was also confirmed by the model reactants. The resultant micropatterned surfaces are meaningful for future studies of cell behaviors on mechanically biomimetic matrixes. | SUN JianGuo GRAETER Stefan V TANG Jian HUANG JingHuan LIU Peng LAI YuXiao YU Lin MAJER Günter SPATZ Joachim P DING JianDong | 2014 | Science China Chemistry2014，57，4： | 2 |
| 7 | Nitrification at low oxygen concentration in biofilm reactor 显示文摘 | Bernet N Peng D C Delgenes J P | 2001 | J Environ Eng ASCE2001，127，3： | 1 |
| 8 | Regulation of hepcidin transcription by interleukin-1 and interleukin-6显示文摘 | Lee P Peng H Gelbart T | 2005 | Proc Natl Acad Sci USA2005，102，6： | 1 |
| 9 | Nitrification at low oxygen concentration in biofilm reactor显示文摘 | Bernet N Peng D C Delgenes J P | 2001 | J Environ Eng2001，127，3： | 1 |
| 10 | Endothelin-1 increases expression of cyclooxygenase-2 and production of interlukin-8 in hunan pulmonary epithelial cells显示文摘 | Peng H Chen P Cai Y | 2008 | Peptides2008，29，3： | 1 |
| 11 | High alpha-fetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma : significance of hepatitis virus infection ,age ,p53 ,and beta-catenin mutations显示文摘 | PENG S Y CHEN W J LAI P L | 2004 | Int J Cancer2004，112，1： | 1 |
| 12 | Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1 alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression显示文摘 | Karna P Cao Z | 2006 | J Biol Chem2006，281，25： | 1 |
| 13 | Structural and PL Properties of Cu-doped ZnO Films显示文摘 | Peng X P Xu J Z Zang H | 2008 | Journal of Luminescence2008，128，： | 1 |
| 14 | Studies on 6,6￠-di-substituted Effects of the dpq in2+ with DFT method显示文摘 | ZHENG K C WANG J P PENG W L | 2001 | J Phys Chem A2001，105，10： | 1 |
| 15 | Sitosterol-D-glucoside as primer for cellulose synthesis in plants显示文摘 | Peng LC Kawagoe Y Hogan P | 2002 | Science2002，295，5552： | 1 |
| 16 | Calculation of stiffness and damping coefficients for elastically supported gas foil bcarings显示文摘 | Peng J P Carpino M | 1993 | ASME Journal of Tribology1993，115，2： | 1 |
| 17 | Synthesis, pH- and temperatureinduced micellization and gelation of doubly hydrophilic triblock copolymer of poly ( N, N-dimethyl atnino-2-ethylmethacrylate ) -b- poly ( ethylene glycol )-b-poly ( N, N-dimethylamino-2- ethylmethacrylate) in aqueous solutions显示文摘 | Peng Z P Li G Z Liu X X | 2008 | J Polym Sci Part A: Polym Chem2008，46，17： | 1 |
| 18 | Molecular biomarker evidence of origins and transport of organic matter in sediments of the Pearl River Estuary and adjacent South China Sea 显示文摘 | HU J F PENG P A CHIVAS A R | 2009 | Applied Geochemistry2009，24，9： | 1 |
| 19 | An Optimization Method Inspired by Chaotic Ant Behavior 显示文摘 | LI L X YANG Y X PENG H P | 2006 | Internation- al Journal of Bifurcation Chaos2006，，16： | 1 |
| 20 | Ruthenium-iron-catalyzed oxidation of an immature asphaltene: Structural features and biomarker distribution显示文摘 | Peng P Fu J Sheng G | 1999 | Energy and Fuel1999，13，2： | 1 |
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