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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Phase 1I tri- al of neoadjuvant gemcitabine and cisplatin in patients with re- sectable bladder carcinoma 显示文摘 | Herchenhorn D l)ienstmann R Peixoto FA | 2007 | J lnt Braz J Urol2007，33，5： | 1 |
| 3 | An empirical model to predict soil bulk density profiles in field conditions using penetration resistance, moisture content and soil depth显示文摘 | Hemanz J L Peixoto H Cerisola Cetal | 2000 | Journal of Terramechanics2000，37，4： | 1 |
| 4 | Leaf damage in a mangrove swamp at Sepetiba Bay, Rio de Janeiro, Brazil 显示文摘 | MENEZES L F T PEIXOTO A L | 2009 | Brazilian Journal of Botany2009，32，4： | 1 |
| 5 | Cystatin C: A Promising: Marker of Renal Function in Patients with Systemic Lupus Erythematosus? 显示文摘 | Peixoto L Aguiar P de Braganca R et aI | 2015 | Acta Med Port2015，28，3： | 1 |
| 6 | In situ microbial fuel cell-based biosensor for organic carbon显示文摘 | Peixoto L Min B Martins G | 2011 | Bioelectrochemistry2011，81，2： | 1 |
| 7 | Genomic analysis of sleep deprivation reveals translational regulation in the bippocampus 显示文摘 | Veesey CG Peixoto L Choi JH | 2012 | Physiol Genomics2012，44，20： | 1 |
| 8 | A simple method for obtaining reusable reactors containing immobilized trehalase:Characterization of a crude trehalase preparation immobilized on chitin particles显示文摘 | MARTINS A S PEIXOTO D N PAIVA L M C | 2006 | Enzyme and Microbial Technology2006，38，： | 1 |
| 9 | Assay of human interferon in Vero cells by several methods 显示文摘 | FERREIRA P C PEIXOTO M L SILVA M A | 1979 | J Clin Microbiol1979，9，4： | 1 |
| 10 | In situ microbial fuel cell-based biosensor for organic carbon 显示文摘 | Peixoto L Min B Martins G | 2011 | Bioelectrochemistry2011，82，2： | 1 |
| 11 | Microstructure and electrochemical corrosion behavior of a Pb-lwt%Sn alloy for lead-acid battery components显示文摘 | PEIXOTO L C OSORIO W R GARCIA A | 2009 | Journal of Power Sources2009，192，： | 1 |
| 12 | The strength of translational selection for codon usage varies in three replicons of Sinorhizobium melioti显示文摘 | Peixoto L Zavala A Romero H Musto H | | 0，，： | 1 |
| 13 | Towards implementation of a benthic microbial fuel cell in lake Furnas (Azores): Phylogenetic affiliation and electrochemical activity of sediment bacteria 显示文摘 | MARTINS G PEIXOTO L RIBEIRO C D | 2010 | Bioelectrochemistry2010，78，1： | 1 |
| 14 | In situ microbial fuel cell-based biosensor for organic carbon显示文摘 | Peixoto L Min B Martins G | 2011 | Bioelectrochemistry2011，81，2： | 1 |
| 15 | The strength of translational selection for codon usage varies in three replicons of Sinorhizoblum melioti 显示文摘 | PEIXOTO L ZAVALA A ROMERO H | 2003 | Gene2003，320，： | 1 |
| 16 | Predisposi- tion to idiopathic thrombocytopenic purpura maps close to the major histocompatibility complex class I chain-related gene A显示文摘 | Maia MH Peixoto Rde L de Lima CP | 2009 | Hum Immunol2009，70，3： | 1 |
| 17 | Towards implementation of a benthic microbial fuel cell in lake Furnas (Azores):Phylogenetic affiliation and electrochemical activity of sediment bacteria显示文摘 | MARTINS G PEIXOTO L RIBEIRO D C | 2010 | Bioelectrochemistry2010，78，1： | 1 |
| 18 | Molecular mechanisms involved in the angiotensin (l 7)/Mas signaling pathway in cardiomyocytes 显示文摘 | Dias Peixoto M F Santos R A Gomes E R Alves M N Alrneida P W Greco L | 2008 | Hypertension2008，52，： | 1 |
| 19 | An empirical model to predict soil bulk density profiles in field conditions using penetration resistance, moisture content and soil depth 显示文摘 | Hernanz J L Peixoto H Cerisola C | 2000 | Journal of Terramechanics2000，37，： | 1 |
| 20 | Soil Aggregation and Bacterial Community Structure as Affected by Till age and Cover Cropping in the Brazilian Cerrados 显示文摘 | Peixoto R S Coutinho H L C Madari B | 2006 | Soil and Tillage Research2006，90，： | 1 |
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