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| 1 | Cardioprotection and pharmacological therapies in acute myocardial infarction: Challenges in the current era显示文摘In patients with an acute ST-segment elevation myocardial infarction, timely myocardial reperfusion using primary percutaneous coronary intervention is the most effective therapy for limiting myocardial infarct size, preserving left-ventricular systolic function and reducing the onset of heart failure. Within minutes after the restoration of blood flow, however, reperfusion itself results in additional damage, also known as myocardial ischemia-reperfusion injury. An improved understanding of the pathophysiological mechanisms underlying reperfusion injury has resulted in the identification ofseveral promising pharmacological(cyclosporin-A, exenatide, glucose-insulin-potassium, atrial natriuretic peptide, adenosine, abciximab, erythropoietin, metoprolol and melatonin) therapeutic strategies for reducing the severity of myocardial reperfusion injury. Many of these agents have shown promise in initial proofof-principle clinical studies. In this article, we review the pathophysiology underlying myocardial reperfusion injury and highlight the potential pharmacological interventions which could be used in the future to prevent reperfusion injury and improve clinical outcomes in patients with coronary heart disease. | Alberto Dominguez-Rodriguez Pedro Abreu-Gonzalez Russel J Reiter | 2014 | World Journal of Cardiology2014，6，3： | 18 |
| 2 | How important is donor age in liver transplantation?显示文摘The age of liver donors has been increasing in the past several years because of a donor shortage. In the United States, 33% of donors are age 50 years or older, as are more than 50% in some European countries. The impact of donor age on liver transplantation(LT) has been analyzed in several studies with contradictory conclusions. Nevertheless, recent analyses of the largest databases demonstrate that having an older donor is a risk factor for graft failure. Donor age is included as a risk factor in the more relevant graft survival scores, such as the Donor Risk Index, donor age and Model for End-stage Liver Disease, Survival Outcomes Following Liver Transplantation, and the Balance of Risk. The use of old donors is related to an increased rate of biliary complications and hepatitis C virus-related graft failure. Although liver function does not seem to be significantly affected by age, the incidence of several liver diseases increases with age, and the capacity of the liver to manage or overcome liver diseases or external injuries decreases. In this paper, the importance of age in LT outcomes, the role of donor age as a risk factor, and the influence of aging on liver regeneration are reviewed. | Alberto Lué Estela Solanas Pedro Baptista Sara Lorente Juan J Araiz Agustin Garcia-Gil M Trinidad Serrano | 2016 | World Journal of Gastroenterology2016，22，21： | 10 |
| 3 | Oral refeeding in mild acute pancreatitis:An old challenge显示文摘Although the idea that pancreas rest has long been considered as a very relevant topic in acute pancreatitis (AP)therapy,the right time and type of diet to be offered to patients recovering from an acute attack are a great challenge to clinicians who treat this condition.Fortunately,the last decade was noted for several trials looking for the best answer to the question:'when and how to start oral refeeding in AP?'It is well known that 80%of patients present with mild disease characterized by usually uncomplicated clinical course are managed with pancreatic rest through nil per oral;while the use of specific nutritional intervention is an exception.Therefore,mild AP has been the most investigated form of AP and researchers have tried different kind of meals to offer calories and reduce costs by shortening hospitalization time.Usually in mild AP,the oral refeeding is introduced between the first 3 d and 7 d after hospitalization but,the type of diet and patients’tolerance have been scrutinized in detail with mixed results.Although 20%to 25%have pain recurrence requiring nutritional support and greater time of hospitalization,most patients seem to tolerate oral refeeding well.We propose analyzing the most recent investigations of this matter and their conclusions to develop a better understanding of the management of AP. | Júlio Maria F Chebli Pedro D Gaburri Liliana A Chebli | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 2 |
| 4 | Comparison between type-2 and type-1 myocardial infarction:clinical features, treatment strategies and outcomes显示文摘ObjectiveTo 与尖锐心肌的梗塞(AMI ).MethodsWe 包括了的 type-2 对 type-1 在病人在发生,临床的特征,当前的治疗策略和结果估计差别有 type-1 或 type-2 AMI 的诊断的 824 个连续病人。在索引住院期间,临床的特征和治疗策略详细被收集。在 1 年的后续,死亡,击,流血的非致命的心肌的梗塞和专业是 recorded.ResultsType-1 AMI 在 707 是在场的(86%) 盒子当(14%) 117 作为 type-2 被分类时。有 type-2 AMI 的病人更经常是象糖尿病那样的女、有的更高的合作病态,以前的非圣片断举起急性冠的症候群,损害肾的功能,贫血症, atrial 纤维性颤动和恶意。然而,保存了左室的喷射部分,正常冠的动脉是经常看见的更多,侵略治疗是不太普通的,并且反血小板药, statins 和 beta-blockers 是在有 type-2 AMI 的病人规定的更少。在 1 年的后续, type-2 AMI 与更高粗略的死亡风险被联系(HR:1.75, 95% CI:1.14-2.68;P = 0.001 ) ,但是这个协会没在 multivariable 调整以后仍然保持重要(P = 0.785 ) 。而且,我们没发现 type-2 AMI 与另外的临床的 outcomes.ConclusionsIn 被联系这张真实人口与 type-1 相比, type-2 AMI 是主要女人们并且有更多的合作病态。侵略治疗策略和 cardioprotective 药是在 type-2 使用的更少,当 1 年的临床的结果是类似的时。 | Angel Lopez-Cuenca Miriam Gomez-Molina Pedro J Flores-Blanco Marianela Sanchez-Martinez Andrea Garcia-Narbon Ignacio De Las Heras-Gomez Maria J Sainchez-Galian Esther Guerrero-Perez Mariano Valdes Sergio Manzano-Femandez | 2016 | Journal of Geriatric Cardiology2016，13，1： | 2 |
| 5 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 6 | Medicinal plants from open-air markets in the State of Rio de Janeiro, Brazil as a potential source of new antimycobacterial agents显示文摘 | Fernanda Leit?o Suzana G. Leit?o Mara Zélia de Almeida Jéssica Cantos Tatiane Coelho Pedro Eduardo A. da Silva | 2013 | Journal of Ethnopharmacology2013，，： | 2 |
| 7 | Polymorphisms in the interleukin-10, tumor necrosis factor-α, and transforming growth factor-β1 genes in chronic hepatitis C patients treated with interferon and ribavirin显示文摘 | Pedro G Vidigal Jeffrey J Germer Nizar N Zein | 2002 | Journal of Hepatology2002，，2： | 2 |
| 8 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 9 | Liver bioengineering:Current status and future perspectives显示文摘The present review aims to illustrate the strategies that are being implemented to regenerate or bioengineer livers for clinical purposes.There are two general pathways to liver bioengineering and regeneration.The first consists of creating a supporting scaffold,either synthetically or by decellularization of human or animal organs,and seeding cells on the scaffold,where they will mature either in bioreactors or in vivo.This strategy seems to offer the quickest route to clinical translation,as demonstrated by the development of liver organoids from rodent livers which were repopulated with organ specific cells of animal and/or human origin.Liver bioengineering has potential for transplantation and for toxicity testing during preclinical drug development.The second possibility is to induce liver regeneration of dead or resected tissue by manipulating cell pathways.In fact,it is well known that the liver has peculiar regenerative potential which allows hepatocyte hyperplasia after amputation of liver volume.Infusion of autologous bone marrow cells,which aids in liver regeneration,into patients was shown to be safe and to improve their clinical condition,but the specific cells responsible for liver regeneration have not yet been determined and the underlying mechanisms remain largely unknown.A complete understanding of the cell pathways and dynamics and of the functioning of liver stem cell niche is necessary for the clinical translation of regenerative medicine strategies.As well,it will be crucial to elucidate the mechanisms through which cells interact with the extracellular matrix,and how this latter supports and drives cell fate. | Christopher Booth Tom Soker Pedro Baptista Christina L Ross Shay Soker Umar Farooq Robert J Stratta Giuseppe Orlando | 2012 | World Journal of Gastroenterology2012，18，47： | 2 |
| 10 | Interchangeability of corneal curvature and asphericity measurements provided by three different devices显示文摘AIM: To evaluate the interchangeability of keratometric and asphericity measurements provided by three measurement systems based on different optical principles.METHODS: A total of 40 eyes of 40 patients with a mean age of 34.1 y were included. In all cases, a corneal curvature analysis was performed with IOL-Master(IOLM), iDesign 2(ID2), and Sirius systems(SIR). Differences between instruments for flattest(K1) and steepest(K2) keratometric readings, as well as for magnitude and axis of corneal astigmatism were analyzed. Likewise, differences in asphericity(Q) between SIR and ID2 were also evaluated. RESULTS: Mean differences between devices for K1 were 0.20±0.21(P<0.001),-0.12±0.36(P=0.046) and-0.32±0.36 D(P<0.001) for the comparisons IOLM-SIR, IOLM-ID2 and SIR-ID2, respectively. The ranges of agreement for these comparisons between instruments were 0.41, 0.70, and 0.70 D. For K2, mean differences were 0.31±0.33(P<0.001),-0.08±0.43(P=0.265) and-0.39±0.38 D(P<0.001), with ranges of agreement of 0.65, 0.84, and 0.74 D. Concerning magnitude of astigmatism, ranges of agreement were in the limit of clinical relevance(0.49 D, P=0.011; 0.55 D, P=0.386; 0.43 D, P=0.05). In contrast, ranges of agreement were clinically relevant for astigmatic axis(26.68o, 33.83o and 18.37o, P≥0.121) and for Q between SIR and ID2(0.16, P<0.001). CONCLUSION: The keratometric corneal power, astigmatic axis and asphericity measurements provideby the three systems evaluated cannot be considered as interchangeable, whereas measurements of corneal astigmatism obtained with SIR and ID2 can be considered as interchangeable for clinical purposes. | David P.Pinero Roberto Soto-Negro Pedro Ruiz-Fortes Rafael J Pérez-Cambrodí Hideki Fukumitsu | 2019 | International Journal of Ophthalmology(English edition)2019，12，3： | 2 |
| 11 | Three-dimensiona superresolution by annular binary filters显示文摘 | Andres Pedro Zapata-Rodryguez Carlos J | 1999 | Optics Communications1999，165，： | 1 |
| 12 | Cleaner water using bimetallic nanoparticle catalysts显示文摘 | Michael S W Pedro J J A Yu-lun Fang | 2009 | Journal of Chemical Technology & Biotechnology2009，84，2： | 1 |
| 13 | Factors affecting secondary metabolite production in plants: Volatile components and essential oils 显示文摘 | Figueiredo A C Barroso J G Pedro L G | 2008 | Flavour Fragr J2008，23，4： | 1 |
| 14 | Neural network based feedback linear- ization control of a servo-hydraulic vehicle suspension system 显示文摘 | Pedro J Dahunsi O | 2011 | International Journal of Applied Mathematics and Com- puter Science2011，21，1： | 1 |
| 15 | Changes in glucose, glycogen, thyroid activity and hypo thalamic catecholamines in tench by starvation and refeeding显示文摘 | Pedro N De Delado M J Gancedo B | 2003 | Journal of Comparative Physiology B: Biochemical Systemic and Environmental Physiology2003，173，6： | 1 |
| 16 | Effects of salt stress on H + -ATPase activity of plasma membrane-enriched vesicles isolated from sunflower roots 显示文摘 | BALLESTEROS E KERKEB B PEDRO J | 1998 | Plant Science1998，134，： | 1 |
| 17 | Evaluation of CCHP systems performance based on operational cost, primary energy consumption, and carbon dioxide emission by utilizing an optimal operation scheme显示文摘 | Cho Heejin Mago Pedro J Luck Rogelio | 2009 | Applied Energy2009，86，12： | 1 |
| 18 | Reference Framework for Enhanced Interoperable Collaborative Networks in? Industrial Organizations 显示文摘 | Ricardo J G Carlos A Joao S Antonio G Pedro M J | 2013 | International Journal of Computer Integrated Manufacturing2013，26，12： | 1 |
| 19 | Gpu based real- lime inslrument tracking with three-dimensional ultrasound显示文摘 | Novotny P M Stoll J A Pedro E Nido J D | 2007 | Medical Image Analysis2007，11，5： | 1 |
| 20 | Apoli- poprotein E genotype affects plasma lipid response to atorvastatin in a gender specific manner 显示文摘 | Pedro - Botet J Schaefer EJ Bakker - Arkema RG | 2001 | Atherosclerosis2001，158，： | 1 |
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