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| 1 | Strong link between large tropical volcanic eruptions and severe droughts prior to monsoon in the central Himalayas revealed by tree-ring records显示文摘Large tropical volcanic eruptions can cause short-term global cooling. However, little is known whether large tropical volcanic eruptions, like the one in Tambora/Indonesia in 1815, cause regional hydroclimatic anomalies. Using a tree-ring network of precisely dated Himalayan birch in the central Himalayas, we reconstructed variations in the regional pre-monsoon precipitation back to 1650 CE. A superposed epoch analysis indicates that the pre-monsoon regional droughts are associated with large tropical volcanic eruptions, appearing to have a strong influence on hydroclimatic conditions in the central Himalayas. In fact, the most severe drought since 1650 CE occurred after the Tambora eruption. These results suggest that dry conditions prior to monsoon in the central Himalayas were associated with explosive tropical volcanism. Prolonged La Ni?a events also correspond with persistent pre-monsoon droughts in the central Himalayas. Our results provide evidence that large tropical volcanic eruptions most likely induced severe droughts prior to monsoon in the central Himalayas. | Eryuan Liang Binod Dawadi Neil Pederson Shilong Piao Haifeng Zhu Shalik Ram Sigdel Deliang Chen | 2019 | Science Bulletin2019，64，14： | 8 |
| 2 | Programmable microfluidic genotyping of plant DNA samples for marker-assisted selection显示文摘As demands to maintain the global food production continue to mount,multinational seed companies are turning to new DNA marker technologies to accelerate the rate of plant breeding and crop improvement.The key to widespread adoption of molecular breeding is the availability of flexible and cost-effective tools that can perform combinatorial and high-throughput genotyping of single-nucleotide polymorphisms(SNPs)to guide the crop development process.Toward this end,we have developed a programmable,droplet-based microfluidic device for genotyping maize genomic DNA.A unique feature of the microfluidic platform is the nano sample processors(NSPs),which allow the device to sequentially load an unrestricted number of unique DNA samples using only two inlets,overcoming the current limitation to the number of sample inputs due to small device footprint.Direct and programmable droplet generation within the device allows each sample to be genotyped against a panel of markers on demand.Moreover,we have successfully implemented the Invader assay for SNP genotyping in flowing,50-nL droplets,thus achieving significant reduction in consumption of reagents per reaction as compared with conventional genotyping platforms.As a demonstration,we performed 240 Invader reactions(testing 8 DNA samples against 10 SNP markers)and achieved greater than 93% accuracy in SNP calling of plant DNA samples in a single droplet-based experiment. | Helena C.Zec Tony Zheng Lingshu Liu Kuangwen Hsieh Tushar D.Rane Todd Pederson Tza-Huei Wang | 2018 | Microsystems & Nanoengineering2018，4，1： | 2 |
| 3 | Identification of breast cancer cell line derived paracrine factors that stimulate osteoclast activity显示文摘 | Pederson L Winding B Foged NT | 1999 | Cancer Res1999，59，22： | 1 |
| 4 | Relationship between dental caries experience and surface enamel fluoride concentration in young men from three optimally fluoridated cities显示文摘 | Keene H J Mellberg JR Pederson ED | 1980 | J Dent Res1980，59，11： | 1 |
| 5 | Lipopmtein changes and reduction in the incidence of major coronary heart disease events in the Scandinavian Simavastatin Survival Study(4s)显示文摘 | Pederson J R Olsson A G Faergeman V | 1998 | Circulation1998，97，15： | 1 |
| 6 | Reduction of infusion thrombophlebitis with buffered glucose solutions显示文摘 | Pederson BM Murphy J | 1968 | Surgery1968，63，： | 1 |
| 7 | Nanocapillarity in fullerene tubules显示文摘 | Pederson M R Broughton J Q | 1992 | Phys Rex Lett1992，69，： | 1 |
| 8 | Aqueous humor dynamics in experimental iridocyclitis显示文摘 | Toris CB Pederson JE | 1987 | Invest Ophthalmol Vis Sci1987，28，3： | 1 |
| 9 | Insuline binding and action on fat cell from young healthy females and males 显示文摘 | Pederson Hiquand E Lindskovlfo | 1982 | Am J physiol1982，243，： | 1 |
| 10 | Replantation显示文摘 | Pederson WC | 2001 | Plast Reconstr Surg2001，109，3： | 1 |
| 11 | A thermodynamic-basedevaluation of organic chemical accumulation in aquatic organisms显示文摘 | CONNOLLY J P PEDERSON C J | 1988 | Environmental Science and Technology1988，22，1： | 1 |
| 12 | Peptidasses and amino acid catabolism in lactic acid bacteria显示文摘 | CHRISTENSEN J E DUDLEY E G PEDERSON J A et al | 1999 | Antonie Van Leeuwenhoek1999，，76： | 1 |
| 13 | Effects of simvas- tatin on ischemic signs and symptoms in the Scandinavian simvastatin survival study 显示文摘 | Pederson TR Kjekshus J Pyorala K | 1998 | AmJ Cardlol1998，，81： | 1 |
| 14 | Bisphosphonates directly regulate cell proliferation,differentiation,and gene expression in human osteoblasts显示文摘 | REINHOLZ GG GETZ B PEDERSON L | | 0，，21： | 1 |
| 15 | Early intervention with budesonide in mild persistent asthma:a randomised,double-blind trial显示文摘 | Pauwels RA Pederson S Busse WW | 2003 | Lancet2003，361，： | 1 |
| 16 | Electronic structure of the molecule-based magnet Mn 2 from theory and experiment 显示文摘 | Pederson M R Liu A Y Baruah T | 2002 | Phys Rev B2002，66，01： | 1 |
| 17 | Efficacy and safety of inhaled corticesteroids in asthma显示文摘 | Barnes PJ Pederson S | 1993 | Am Rev Respir Dis1993，148，42： | 1 |
| 18 | Deception awareness improves P300-based deception detection in concealed information tests显示文摘 | ROSENFELD J P HU X PEDERSON K | 2012 | Internation Journal of Psychophy siology2012，86，1： | 1 |
| 19 | Measurements of interleukin-6 in gingival crevicular fluid from adults with destructive periodontal disease显示文摘 | Geivelis M Turner DW Pederson ED | 1993 | J Periodontol1993，64，10： | 1 |
| 20 | Contributions of the brain angiotensin Ⅳ-AT4 receptor subtype system to spatial learning显示文摘 | Wright JW Stubley L Pederson ES | 1999 | J Neurosci1999，19，10： | 1 |
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