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2篇 您的检索式：作者名="PAVEL MATULA"

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		题名	作者	年代	出处	被引量
	1	SUV39h-independent association of HP1β with fibrillarin-positive nucleolar regions显示文摘	Andrea Harni?arová Horáková Eva Bártová Gabriela Galiová Radka Uhlí?ová Pavel Matula Stanislav Kozubek	2010	Chromosoma2010，，3：	1
	2	Knockdown of apoptosis-inducing factor disrupts function of respiratory complex I显示文摘Recent findings suggest that apoptotic protein apoptosis-inducing factor (AIF) may also play an important non-apoptotic function inside mitochondria. AIF was proposed to be an important component of respiratory chain complex I that is the major producer of superoxide radical. The possible role of AIF is still controversial. Superoxide production could be used as a valuable measure of complex I function, because the majority of superoxide is produced there. Therefore, we employed superoxide-specific mitochondrial fluo- rescence dye for detection of superoxide production. We studied an impact of AIF knockdown on function of mitochondrial complex I by analyzing superoxide production in selected cell lines. Our results show that tumoral telomerase-positive (TP) AIF knockdown cell lines display significant increase in superoxide pro- duction in comparison to control cells, while a non-tumoral cell line and tumoral telomerase-negative cell lines with alternative lengthening of telomeres (ALT) show a decrease in superoxide production. According to these results, we can conclude that AIF knockdown disrupts function of complex I and therefore increases the superoxide production in mitochondria. The distinct effect of AIF depletion in various cell lines could result from recently discovered activity of telomerase in mitochondria of TP cancer cells, but this hypothesis needs further investigation.	MIROSLAV VAˇRECHA DANIELA PÁCLOVÁ JIˇRINA PROCHÁZKOVÁ PAVEL MATULA DUˇSAN CMARKO AND MICHAL KOZUBEK	2012	BIOCELL2012，36，3：	0

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