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		题名	作者	年代	出处	被引量
	1	Co-expression of CDX2 and MUC2 in gastric carcinomas: Correlations with clinico-pathological parameters and prognosis显示文摘AIM: To evaluate the role of CDX2 homeobox protein as a predictor for cancer progression and prognosis as well as its correlation with MUC2 expression. CDX2 represents a transcription factor for various intestinal genes (including MUC2) and thus an important regulator of intestinal differentiation, which could previously be identified in gastric carcinomas and intestinal metaplasia.METHODS: Formalin-fixed and paraffin-embedded tissues from 190 gastric carcinoma patients were stained with monodonal antibodies recognizing CDX2 and MUC2, respectively. Immunoreactivity was evaluated semiquantitatively and statistical analyses including χ2 tests, uni- and multi-variate survival analyses were performed.RESULTS: CDX2 was mostly expressed in a nuclear or supranuclear pattern, whereas MUC2 showed an almost exclusive supranuclear reactivity. Both antigens were present in >80% of areas exhibiting intestinal metaplasia. An immunoreactivity in >5% of the tumor area was observed in 57% (CDX2) or in 21% (MUC2) of the carcinomas. The presence of both molecules did not correlate with WHO,significantly stronger vlUC2 expression in mucinous tumors). CDX2 correlated with a lower pT and pN stage in the subgroups of intestinal and stage I cancers and was associated with MUC2 positivity. A prognostic impact of CDX2 or MUC2 was not observed. CONCLUSION: CDX2 and MUC2 play an important role in the differentiation of normal, inflamed, and neoplastic gastric tissues. According to our results, loss of CDX2 may represent a marker of tumor progression in early gastric cancer and carcinomas with an intestinal phenotype.	Kristina Roessler Stefan P.M(o\|¨)nig Paul M.Schneider Franz-Georg Hanisch Stephanie Landsberg Juergen Thiele Arnulf H.H(o\|¨)lscher Hans P.Dienes Stephan E.Baldus	2005	World Journal of Gastroenterology2005，11，21：	15
	2	Direct electrochemical reduction of indigo显示文摘	Albert Roessler David Crettenand Otmar Dossenbach Walter Marte Paul Rys	2002	Electrochimica Acta2002，47，12：	1
	3	Direct electrochemical reduction of indigo显示文摘	Albert Roessler David Crettenand Otmar Dossenbach Walter Marte Paul Rys	2002	Electrochemical Acta2002，，47：	1
	4	Direct Electrochemical Reduction of Indigo显示文摘	Albert Roessler David Crettend Otmar Dossenbach Walter Matte Paul Rys		0，，：	1
	5	Production of polyunsaturated fatty acids by polyketide synthases in both prokaryotes and eukaryotes 显示文摘	JAMESG METZ PAUL ROESSLER DANIEL FACCIOTTI	2001	Science2001，293，：	1

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