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| 1 | Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma显示文摘Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis,cancer,and liver failure.Liver cancer is the third leading cause of cancer-associated mortality,of which hepatocellular carcinoma(HCC)represents 90%of all primary liver cancers.Solid tumors like HCC are complex and have heterogeneous tumor genomic profiles contributing to complexity in diagnosis and management.Chronic infection with hepatitis B virus(HBV),hepatitis delta virus(HDV),and hepatitis C virus(HCV)are the greatest etiological risk factors for HCC.Due to the significant role of chronic viral infection in HCC development,it is important to investigate direct(viral associated)and indirect(immune-associated)mechanisms involved in the pathogenesis of HCC.Common mechanisms used by HBV,HCV,and HDV that drive hepatocarcinogenesis include persistent liver inflammation with an impaired antiviral immune response,immune and viral protein-mediated oxidative stress,and deregulation of cellular signaling pathways by viral proteins.DNA integration to promote genome instability is a feature of HBV infection,and metabolic reprogramming leading to steatosis is driven by HCV infection.The current review aims to provide a brief overview of HBV,HCV and HDV molecular biology,and highlight specific viral-associated oncogenic mechanisms and common molecular pathways deregulated in HCC,and current as well as emerging treatments for HCC. | Simmone D'souza Keith CK Lau Carla S Coffin Trushar R Patel | 2020 | World Journal of Gastroenterology2020，26，38： | 25 |
| 2 | Later dislocation of a LASIK flap caused by a finger 显示文摘 | Patel CK | 2001 | Arch Ophthalmol2001，119，7： | 1 |
| 3 | Outcome of local bone versus autogenous iliac crest bone graft in the instrumen- ted posterolateral fusion of the lumbar spine显示文摘 | Sengupta DK Truumees E Patel CK | 2006 | Spine2006，31，9： | 1 |
| 4 | Videoendoscope-guided fluo- rescein-assisted vitrectomy for phakic malignant glaucoma显示文摘 | Chen SD Salmon JF Patel CK | 2005 | Arch Ophthalmol2005，123，10： | 1 |
| 5 | Optical coherence tomography in the management of acute retinopathy of prematurity显示文摘 | Patel CK | 2006 | Am J Ophthalmol2006，141，： | 1 |
| 6 | Effects of perioperative red blood cell transfusion on disease recurrence and survival after pancreaticoduodenectomy for ductal adenocarcinoma显示文摘 | Kneuertz P J Patel SH Chu CK | 2011 | Ann Surg Oncol2011，18，5： | 1 |
| 7 | Sub -Tenon's local anaesthesia for the treatment of retinopathy of prematurity with diode laser 显示文摘 | Parulekar MV Chen SD Patel CK | 2008 | Eye (Lond)2008，22，3： | 1 |
| 8 | Techniques in cervical laminoplasty显示文摘 | Patel CK Cunningham BJ Herkowitz HN | 2002 | Spine J2002，2，6： | 1 |
| 9 | Postopera- tive intraoeular lens rotation: a randomized com- parison of plate and loop haptic implants显示文摘 | Patel CK Ormonde S Rosen PH | 1999 | Oph- thalmology1999，106，： | 1 |
| 10 | Postoperative intraocular lens rotation:a randomized comparison of plate and loop haptic implants显示文摘 | Patel CK Ormonde S Rosen PH | | 0，，： | 1 |
| 11 | Sub-Tenont s local anaesthesia for the treatment of retinopathy of prematurity with diode laser 显示文摘 | Parulekar MV Chen SD Patel CK | 2008 | Eye( Lond)2008，22，3： | 1 |
| 12 | Irreversible intrapulmonary vascular changes after pulmonary vein stenosis complicating catheter ablation for atrial fibrillation 显示文摘 | Yang HM Lai CK Patel J | 2007 | Cardiovascular pa- thology : the official journal of the Society for Cardiovascular Pathology2007，16，1： | 1 |
| 13 | Postoperative mtraocular lens rotation: a randomized comparison of plate and loop haptic implants显示文摘 | Patel CK Onnonde S Rosen PH Bron AJ | 1999 | Ophthalmology1999，106，11： | 1 |
| 14 | Postoperative rotation of a 3-piece loop-haptic acrylic intraocular lens 显示文摘 | Saldanha MJ Benjamin L Patel CK | 2009 | J Cataract Refract Surg2009，35，10： | 1 |
| 15 | Postoperative intraocularlens rotation:a randomized comparison of plate and loop haptic implants显示文摘 | Patel CK Ormonde S Rosen PH | 1999 | Ophthalmology1999，106，： | 1 |
| 16 | llae role oi ~ww producing PGPR in sustainable agriculture显示文摘 | Saraf M deaminase Jha CK Patel D | 2010 | Microbiology Monographs2010，18，： | 1 |
| 17 | Congenital diaphragmatic hernia: prognostic indices in the fetal endoluminal tracheal occlusion era显示文摘 | Sinha CK Islam S Patel S Nicolaides K Greenough A Davenport M | 2009 | J Pediatr Surg2009，44，2： | 1 |
| 18 | Techniques in cervical laminoplasty显示文摘 | Patel CK Cunningham BJ Herkowitz HN | 2002 | The Spine Journal2002，2，： | 1 |
| 19 | A global lab against influenza显示文摘 | Layne SP Beugelsdijk TJ Patel CK | 2001 | Science2001，293，5536： | 1 |
| 20 | A global lab against influenza显示文摘 | Layne SP Beugelsdijk TJ Patel CK | 2001 | Science2001，293，5536： | 1 |
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