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| 1 | COVID-19 and liver injury: An ongoing challenge显示文摘The new coronavirus severe acute respiratory syndrome coronavirus 2(SARSCoV-2)was identified in December 2019,in Wuhan,China.The virus was rapidly spread worldwide,causing coronavirus disease 2019(COVID-19)pandemic.Although COVID-19 is presented,usually,with typical respiratory symptoms(i.e.,dyspnea,cough)and fever,extrapulmonary manifestations are also encountered.Liver injury is a common feature in patients with COVID-19 and ranges from mild and temporary elevation of liver enzymes to severe liver injury and,even,acute liver failure.The pathogenesis of liver damage is not clearly defined;multiple mechanisms contribute to liver disorder,including direct cytopathic viral effect,cytokine storm and immune-mediated hepatitis,hypoxic injury,and druginduced liver toxicity.Patients with underlying chronic liver disease(i.e.,cirrhosis,non-alcoholic fatty liver disease,alcohol-related liver disease,hepatocellular carcinoma,etc.)may have greater risk to develop both severe COVID-19 and further liver deterioration,and,as a consequence,certain issues should be considered during disease management.The aim of this review is to present the prevalence,clinical manifestation and pathophysiological mechanisms of liver injury in patients with SARS-CoV-2 infection.Moreover,we overview the association between chronic liver disease and SARS-CoV-2 infection and we briefly discuss the management of liver injury during COVID-19. | Ioanna Papagiouvanni Serafeim-Chrysovalantis Kotoulas Athanasia Pataka Dionisios G Spyratos Konstantinos Porpodis Afroditi K Boutou Georgios Papagiouvannis Ioanna Grigoriou Christos Vettas Ioannis Goulis | 2023 | World Journal of Gastroenterology2023，29，2： | 2 |
| 2 | Water stress affects leaf anatomy,gas exchange,water relations and growth of two avocado cultivars显示文摘 | Chartzoulakis K Patakas A Kofidis G1 Bosabalidis A Nastou A | 2002 | Scientia Horticulturae2002，95，： | 1 |
| 3 | Effects of chilling stress on leaf morphology,anatomy,ultrastructure,gas exchange,and essentialoils in the seasonally dimorphic plant Teucrium polium( Lamiaceae) 显示文摘 | Lianopoulou V Bosabalidis A M Patakas A | 2014 | Acta Physiologiae Plantarum2014，36，8： | 1 |
| 4 | Pathogenetic pathways and novel pharmacotherapeutic targets in idiopathic pulmonary fibrosis 显示文摘 | Antoniou K Pataka A Bouros D | 2007 | Pulm Pharmacol Ther2007，20，： | 1 |
| 5 | Nocturnal hypoxia in unilateral diaphragrnatic paralysis显示文摘 | Patakas D Tara V Zoglopiti F | 1991 | Respiration1991，19，3： | 1 |
| 6 | Water stress affects leaf anatomy, gas exchange, water relations and growth of two avoca- do cuhivars 显示文摘 | Chartzoulakis K Patakas A Kofidis G | 2002 | Scientia Horticulturae2002，95，1： | 1 |
| 7 | Water stress affects leaf anatomy,gas exchange,water relations and growth of two avocado cultivars显示文摘 | CHARTZOULAKIS K PATAKAS A KOFIDIS G | | 0，，1： | 1 |
| 8 | Water stress affects leaf anatomy,gas exchange,water relations and growth of two avocado cultivars显示文摘 | Chartzoulakis K Patakas A Kofidis G | 2002 | Scientia Horticulturae2002，95，： | 1 |
| 9 | Identifying the cells breaching self-tolerance in autoimmunity 显示文摘 | BENSON RA PATAKAS A CONIGLIARO P | 2010 | J Immunol2010，184，11： | 1 |
| 10 | Reduced barnreeeptor sensitivity in patients with chronic, obstructive pulmonary disease 显示文摘 | Patakas D Louridas G Kakavelas E | 1952 | Thorax1952，37，4： | 1 |
| 11 | Abataeept limits breach of serf-tolerance in a murine model of arthritis via effects on the genera- tion of T follicular helper cells 显示文摘 | Platt AM Gibson VB Patakas A | 2010 | J Immunol2010，185，3： | 1 |
| 12 | The obstructive sleep apnoea/hypopnoea syndrome-An overview 显示文摘 | Pataka A Riha L | 2009 | Respiratory Medicine CME2009，2，3： | 1 |
| 13 | The relationships between CO2 transfer mesophyll resistance and photosynthetic efficiency in grapevine cultivars显示文摘 | Patakas A Kofidis G Bosabalidis M A | 2003 | Scientia Horticulturae2003，97，25： | 1 |
| 14 | The role of organic solute and ion accumulation in osmotic adjustment in droughtstressed grapevines显示文摘 | Patakas A Nikolaoua N Ziozioua E | 2002 | Plant Science2002，163，： | 1 |
| 15 | Water stress affects leaf anatomy, gas exchange, water relations and growth of two avocado cultivars显示文摘 | Chartzoulakis K Patakas A Kofidis G Bosabalidis A Nastou A | 2002 | Sci Hortic2002，95，12： | 1 |
| 16 | The role of organic solute and ion accumulation in osmotic adiustment in drought- stressed grapevines显示文摘 | PATAKAS A NIKOLAOU N ZIOZIOU E | 2002 | Plant Science2002，163，： | 1 |
| 17 | Water stress affects leaf anatomy, gas exchange, water relations and growth of two avocado cul- tivars 显示文摘 | Chartzoulakis K Patakas A Kofidis G | 2002 | Scientia Horticulturae2002，95，12： | 1 |
| 18 | Changes in water relations, photosynthesis and leaf anatomy induced by intermittent drought in two olive cultivars显示文摘 | Chartzoulakis K Patakas A Bosabalidis A M | 1999 | Environmental and Experimental Botany1999，42，2： | 1 |
| 19 | Buspirone effect on breathlessness and exercise performance in patients with chronic obstructive pulmonary disease显示文摘 | Argyropoulou P Patakas D Koukou A | 1993 | Respiration1993，60，4： | 1 |
| 20 | Change in water relations,photosynthesis and leaf anatomy induced by intermittent drought in two olive cultivars显示文摘 | Chartzoulakis K Patakas A Bosabalidis A M | 1999 | Environ Exp Bot1999，42，： | 1 |
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