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| 1 | Sessile serrated adenomas:Demographic,endoscopic and pathological characteristics显示文摘AIM:To study the demographic and endoscopic characteristics of patients with sessile serrated adenoma(SSA) in a single center.METHODS:Patients with SSA were identified by review of the pathology database of Mayo Clinic Arizona from 2005 to 2007.A retrospective chart review was performed to extract data on demographics,polyp characteristics,presence of synchronous adenomatous polyps or cancer,polypectomy methods,and related complications.RESULTS:One hundred and seventy-one(2.9%) of all patients undergoing colonoscopy had a total of 226 SSAs.The mean(SE) size of the SSAs was 8.1(0.4) mm;42% of SSAs were ≤ 5 mm,and 69% were ≤ 9 mm.Fifty-one per cent of SSAs were located in the cecum or ascending colon.Approximately half of the patients had synchronous polyps of other histological types,including hyperplastic and adenomatous polyps.Synchronous adenocarcinoma was present in seven(4%) cases.Ninety-seven percent of polyps were removed by colonoscopy.CONCLUSION:Among patients with colon polyps,2.9% were found to have SSAs.Most of the SSAs were located in the right side and were safely managed by colonoscopy. | Suryakanth R Gurudu Russell I Heigh Giovanni De Petris Evelyn G Heigh Jonathan A Leighton Shabana F Pasha Isaac B Malagon Ananya Das | 2010 | World Journal of Gastroenterology2010，16，27： | 7 |
| 2 | Serological profiling of Crohn’s disease and ulcerative colitis patients reveals anti-microbial antibody signatures显示文摘BACKGROUND The healthcare burden of inflammatory bowel disease(IBD)is rising globally and there are limited non-invasive biomarkers for accurate and early diagnosis.AIM To understand the important role that intestinal microbiota play in IBD pathogenesis and identify anti-microbial antibody signatures that benefit clinical management of IBD patients.METHODS We performed serological profiling of 100 Crohn’s disease(CD)patients,100 ulcerative colitis(UC)patients and 100 healthy controls against 1173 bacterial and 397 viral proteins from 50 bacteria and 33 viruses on protein microarrays.The study subjects were randomly divided into discovery(n=150)and validation(n=150)sets.Statistical analysis was performed using R packages.RESULTS Anti-bacterial antibody responses showed greater differential prevalence among the three subject groups than anti-viral antibody responses.We identified novel antibodies against the antigens of Bacteroidetes vulgatus(BVU_0562)and Streptococcus pneumoniae(SP_1992)showing higher prevalence in CD patients relative to healthy controls.We also identified antibodies against the antigen of Streptococcus pyogenes(SPy_2009)showing higher prevalence in healthy controls relative to UC patients.Using these novel antibodies,we built biomarker panels with area under the curve(AUC)of 0.81,0.87,and 0.82 distinguishing CD vs control,UC vs control,and CD vs UC,respectively.Subgroup analysis revealed that penetrating CD behavior,colonic CD location,CD patients with a history of surgery,and extensive UC exhibited highest antibody prevalence among all patients.We demonstrated that autoantibodies and anti-microbial antibodies in CD patients had minimal correlation.CONCLUSION We have identified antibody signatures for CD and UC using a comprehensive analysis of antimicrobial antibody response in IBD.These antibodies and the source microorganisms of their target antigens improve our understanding of the role of specific microorganisms in IBD pathogenesis and,after future validation,should aid early and accurate diagnosis of IBD. | Mahasish Shome Lusheng Song Stacy Williams Yunro Chung Vel Murugan Jin G Park William Faubion Shabana F Pasha Jonathan A Leighton Joshua LaBaer Ji Qiu | 2022 | World Journal of Gastroenterology2022，28，30： | 1 |
| 3 | NT-pro-BNP levels in patients with acute pulmonary embolism are correlated to right but not left ventficular volume and function显示文摘 | Pasha S M Klok F A van der Bijl N | 2012 | Thromb Haemost2012，108，2： | 1 |
| 4 | Utility of standard nutritional parameters in detecting body cell mass depletion in patients with end stage liver disease显示文摘 | Dickson E R Pasha T M | 2000 | Liver Transpl2000，6，5： | 1 |
| 5 | Double-balloon enteroscopy and capsule endoscopy have comparable diagnostic yield in small-bowel disease: a meta-analysis显示文摘 | PASHA S F LEIGHTON J A DAS A | 2008 | Clinical Gastroenterology and Hepatology2008，6，6： | 1 |
| 6 | Establishment of human heterohybridoma and lymphoblastoid cell lines specific for the Rh D and C antigens显示文摘 | Pasha RP ROOhi A Shokri F | 2003 | Transfus Med2003，13，2： | 1 |
| 7 | Amino acid composition of spring wheat and losses of lysine during chapatti baking显示文摘 | Anjum F M Ahmad I Butt M S Sheikh M A Pasha I | 2005 | Journal of Food Composition and Analysis2005，18，6： | 1 |
| 8 | Doubleballoon enteroscopy and capsule endoscopy have comparable diagnostic yield in small-bowel disease:a meta-analysis显示文摘 | Pasha S F Leighton J A Das A | 2008 | Clin Gastroenterol Hepatol2008，6，6： | 1 |
| 9 | Comparative QSAR Study of Phenol Derivatives with the Help of Density Functional Theory 显示文摘 | PASHA F A SRIVASTAVA H K AND SINGH P P | 2005 | Bioorganic2005，13，： | 1 |
| 10 | Safety of excludiug at:ute pulmonary embolism based on an unlikely clinical Probability by the Wells rule and normal D-dimer concentration: A recta-analysis显示文摘 | Pasha S M Klok F A Snoep J D | 2010 | Thromb Res2010，125，2： | 1 |
| 11 | Establishment of human heterohybridoma and lymphoblastoid cell lines specific for the Rh D and C antigens显示文摘 | Pasha RP Roohi A Shokri F | 2003 | Transfus Med2003，13，2： | 1 |
| 12 | The role of endoscopy in the patient with lower GI bleeding显示文摘 | Pasha S F Shergill A Acosta R D | 2014 | Gastrointest Endosc2014，79，6： | 1 |
| 13 | Catechin protects against oxidative stress and inflammatory-mediated cardiotoxicity in adriamycintreated rats显示文摘 | ABD EL-AZIZ T A MOHAMED R H PASHA H F | 2012 | Clin Exp Med2012，12，： | 1 |
| 14 | 显示文摘 | PASHA F A MUDDASSAR M LEE C L | 2008 | Environ Toxicol Pharm2008，26，： | 1 |
| 15 | Endoscopic treatment of anasto- motic biliary strictures after deceased donor liver trans- plantation: outcomes after maximal stent therapy显示文摘 | Pasha S F Harrison M E Das A Nguyen C C Vargas H E Balan V | 2007 | Gastrointest Endosc2007，66，： | 1 |
| 16 | Cytokines genes polymorphisms in chronic hepatitis C : impact on susceptibil- ity to infection and response to therapy 显示文摘 | PASHA H F RADWAN M I HAGRASS H A | 2013 | Cytokine2013，61，2： | 1 |
| 17 | Establishment of human heterohybridoma and lymphoblastoid cell lines specific for the Rh D and C antigens显示文摘 | Pasha RP Roohi A Shokri F | 2003 | Transfus Med2003，13，2： | 1 |
| 18 | Procedure time and the de- termination of polypoid abnormalities with experience : implementa- tion of a chromoendoscopy program for surveillance colonoscopy for ulcerative colitis显示文摘 | Picco M F Pasha S Leighton J A | 2013 | Inflamm Bowel Dis2013，19，： | 1 |
| 19 | Establishment of human heterohy-bridoma and lymphoblastoid cell lines specific for the Rh D and C antigens 显示文摘 | Pasha RP Roohi A Shokri F | 2003 | Transfus Med2003，13，2： | 1 |
| 20 | Establishment of human heterohybridoma and lymphoblastoid cell lines specific for the Rh D and C antigens显示文摘 | Pasha RP ROOhi A Shokri F | 2003 | Transfus Med2003，13，2： | 1 |
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