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| 1 | Generalized megaviscera of lupus:Refractory intestinal pseudo-obstruction,ureterohydronephrosis and megacholedochus显示文摘Dilated dysfunction involving multiple visceral organs has been reported in patients with systemic lupus erythematosus(SLE).Chronic intestinal pseudo-obstruction(CIPO) resulting from intestinal smooth muscle damage has presented in conjunction with ureterohydronephrosis and, more rarely, biliary dilatation(megacholedochus).While the molecular pathogenesis is largely unknown, observed histo-pathologic features include widespread myositis, myocyte necrosis in the intestinal muscularis propria with subsequent atrophy and fibrosis, preserved myenteric innervations and little vasculitis.High dose immunosuppression usually results in resolution of symptoms with recovery of smooth muscle function, indicative of an autoimmune etiology.We report a patient with SLE who presented with intestinal pseudo-obstruction, ureterohydronephrosis and megacholedochus, and present images that illustrate megaviscera simultaneously involving all 3 visceral organs.Since the co-manifestation of all 3 is unusual and has been reported only once previously, wehave termed this rare clinical syndrome generalized megaviscera of lupus(GML).Although the SLE disease-activity parameters responded to aggressive immunomodulative therapy in our patient, clinical evidence of peristaltic dysfunction persisted in all involved viscera.This is a variation from the favorable outcomes reported previously in SLE patients with GML and we attribute this poor clinical outcome to disease severity and, most importantly, delayed clinical presentation.Since inflammation followed by atrophy and fibrosis are key aspects in the pathogenesis and natural history of GML, the poor response in our patient who presented late in the clinical course may be the result of ‘burnt out' inflammation with irreversible end-stage flbrosis.Thus, early recognition and timely initiation of treatment may be the key to recover visceral peristaltic function in patients with GML. | Frederick D Park Jeffrey K Lee Ganga D Madduri Pradipta Ghosh | 2009 | World Journal of Gastroenterology2009，15，28： | 20 |
| 2 | 地理信息系统技术在伤寒发热监测中应用显示文摘目的运用地理信息系统(GIS)技术,了解各居民点发热流行率和评价以医疗机构为哨点的伤寒发热监测系统的敏感性。方法收集医学人口普查数据、疾病监测系统信息数据、现场采集居民居住点全球卫星定位数据等资料,建立GIS系统和以人口为基数的发热监测系统;对所有发热就诊病人进行身份和居住地址确认,并制作各居民点年发热就诊率GIS分布图。结果共采集3776个居民居住的全球定位系统(GPS)定位点,人群发热就诊率为1.11‰,发热就诊人次占总门诊人次的16.3%,监测区内的发热就诊病人占所有发热就诊病人的83.5%。在3种类型的医疗机构中,门诊量以个体门诊类最多,但其发热就诊人次占总门诊人次的比率最低(12.6%)。监测区内发热1d或以上的病人地址和身份(ADDRESS-ID)确认率达到95%。根据居民点年发热就诊率GIS分布图,发热就诊率最高的居民点达到17.81‰,最低为0;发热就诊率高的居民点多集中在城市。结论利用GIS技术可直观准确的了解疾病流行率的分布,可迅速直观的寻找出监测系统中的薄弱环节和推断出可能存在的问题。 | 杨进 董柏青 张杰 廖和壮 梁大斌 吴兴华 司国爱 杨宏徽 Jin Kyung Park R Leon Ochiai Camilo J Acosta Moharmmad Ali John D Clemens | 2007 | 中国公共卫生2007，23，9： | 8 |
| 3 | Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study显示文摘 | Hedy L Kindler Tatsuya Ioka Dirk J Richel Jaafar Bennouna Richard Létourneau Takuji Okusaka Akihiro Funakoshi Junji Furuse Young Suk Park Shinichi Ohkawa Gregory M Springett Harpreet S Wasan Peter C Trask Paul Bycott Alejandro D Ricart Sinil Kim Eric Van | 2011 | Lancet Oncology2011，，3： | 4 |
| 4 | Salvage gamma knife stereotactic radiosurgery followed by bevacizumab for recurrent glioblastoma multiforme: a case-control study显示文摘We evaluated the efficacy and safety of gamma knife stereotactic radiosurgery(GKSR)followed by bevacizumab combined withchemotherapy in 11 patients with recurrent glioblastoma multiforme who experienced tumor progression despite aggressive | Park KJ Kano H Iyer A Liu X Niranjan A Flickinger JC Lieberman FS Lunsford LD Kondziolka D | 2012 | 中国神经肿瘤杂志2012，10，4： | 3 |
| 5 | Direct cardiac and vascular action of adrenomedullin in conscious sheep 显示文摘 | PARKES D G MAY C N | 1997 | Br J Pharmacol1997，120，6： | 2 |
| 6 | Design of an iterative learning control for a class of linear dynamic systems with time delay 显示文摘 | PARK K H BIEN Z HWANG D H | 1998 | IEE Proc-D: Control Theory and Applications1998，145，6： | 2 |
| 7 | SiO2 aerogel film as a novel intermetal dielectric 显示文摘 | Jo M H Park H H Kim D J | 1997 | J Appl Phys1997，82，3： | 2 |
| 8 | O′- zirconia and its refractory application显示文摘 | HOGGARD D B PARK Han K | 1990 | Am Ceram Soc Bull1990，69，7： | 2 |
| 9 | Electric load forecasting using an artificial neural network 显示文摘 | Park D C El-Sharkawi M A Marks R J | 1991 | IEEE Transactions on Power Systems1991，6，2： | 2 |
| 10 | O′-zirconia and its refractory application显示文摘 | HOOGGARD D B PARK H K | 1990 | Am Ceram Soc Bull1990，69，7： | 2 |
| 11 | Production of alpha-1,3- galactosyl transferase knockout pigs by nuclear transfer cloning 显示文摘 | Lai L Kolber-Simonds D Park KW | 2002 | Science2002，295，： | 1 |
| 12 | Improved serpentine laminating micromixer with enhanced local advection显示文摘 | PARK J M KIM D S KANG T G | 2008 | Microfluidics and Nanofluidics2008，4，6： | 1 |
| 13 | Discovery of genes for ginsenoside biosynthesis by analysis of ginseng expressed sequence tags显示文摘 | Jung J D Park H W Hahn Y- | 2003 | Plant Cell Rep2003，22，3： | 1 |
| 14 | Resistive switching behavior of Cr-doped SrZrO3 perovskite thin films for random access memory applications 显示文摘 | Yang M K Kim D Y Park J W | 2005 | J Korean Phy Soc2005，47，： | 1 |
| 15 | Reduction of ethyl benzoylacetate and selective protection of 2- (3-hydroxy-1- phenylpropyl) -4-methylphenol: A new and facile synthesis of tolterodine 显示文摘 | De Castro KA Ko J Park D | 2007 | Org Process Res Dev2007，11，5： | 1 |
| 16 | 3D welding and milling:Part I-a direct approach for freeform fabrication of metallic prototypes显示文摘 | Song Y A Park S Choi D | 2005 | International Journal of Machine Tools and Manufacture2005，45，9： | 1 |
| 17 | Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid 显示文摘 | Mucida D Park Y Kim G | 2007 | Science2007，317，5835： | 1 |
| 18 | 显示文摘 | Kweon D K Song S B Park Y Y | 2003 | Biomaterials2003，24，： | 1 |
| 19 | Structural,Electrical and Optical PropoSes of Aluminum Doped Zinc Oxide Films Prepared by Radio Frequency Magnetron Sputtering显示文摘 | Park K C Ma D Y | 1997 | Appl Phys1997，81，12： | 1 |
| 20 | Processing optimization and functional properties of gelatin from shark (Isurus oxyrinchus ) cartilage显示文摘 | CHO S M KWAK K S PARK D C | 2004 | Food Hydrocolloids2004，18，： | 1 |
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