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| 1 | Role of melatonin on diabetes-related metabolic disorders显示文摘Melatonin is a circulating hormone that is mainly re- leased from the pineal gland. It is best known as a regulator of seasonal and circadian rhythms, its levels being high during the night and low during the day. Interestingly, insulin levels are also adapted to day/night changes through melatonin-dependent synchronization. This regulation may be explained by the inhibiting action of melatonin on insulin release, which is transmitted through both the pertussis-toxin-sensitive membrane receptors MT1 and MT2 and the second messengers 3',5' -cyclic adenosine monophosphate, 3',5'-cyclic guanosine monophosphate and inositol 1,4,5-trisphosphate. Melatonin may influence diabetes and associated metabolic disturbances not only by regulating insulin secretion, but also by providing protection against reactive oxygen species, since pancreatic β-cells are very susceptible to oxidative stress because they possess only low-antioxidative capacity. On the other hand, in several genetic association studies, single nucleotide polymorphysms of the human MT2 receptor have been described as being causally linked to an elevated risk of developing type 2 diabetes. This suggests that these individuals maybe more sensitive to the actions of melatonin, thereby leading to impaired insulin secretion. Therefore, block- ing the melatonin-induced inhibition of insulin secretion may be a novel therapeutic avenue for type 2 diabetes. | Javier Espino José A Pariente Ana B Rodríguez | 2011 | World Journal of Diabetes2011，2，6： | 11 |
| 2 | Urban Park Soil and Vegetation: Effects of Natural and Anthropogenic Factors显示文摘Various soil surface components, such as trees, shrubs and biological crusts, and human recreational activities, e.g., barbecues and trampling by visitors, may divide the area of the urban park into smaller fragments/microenvironments, differentiated by their microenvironmental conditions, which may differ in soil and vegetation characteristics. The spatial changes in the soil and vegetation characteristics and their causes were investigated in an urban park located south of Tel Aviv-Jaffa, Israel. The area of the park is 0.5km2, including groves, a lake, lawns, and rest areas. Soil was sampled in nine microenvironments, of which seven were within the park:under Ceratonia siliqua trees(Cs U), under Ficus sycomorus trees(Fi U), rest area between tables under F. sycomorus(Fi B), rest area under tables under F. sycomorus(Fi T), open area with bare soil(Oa S), open area with biological crust cover(Oa C), and open area covered by herbaceous vegetation(Oa V). Two more microenvironments, planar and sloping open areas(Co P and Co S, respectively) in the vicinity of the park, were used as the controls. Electrical conductivity, concentrations of soluble ions(Mg2+, Ca2+, Na+, K+and HCO-3), p H, contents of organic carbon, calcium carbonate and moisture, and grain size distribution were determined. In addition,herbaceous vegetation cover, number and diversity of herbaceous vegetation species were measured. It was found that soil properties and herbaceous vegetation characteristics varied within the park. Soil organic carbon, electrical conductivity, soluble salts, penetration depth, and vegetation characteristics were affected by human activities, mainly in the rest area between the tables. In contrast, the above characteristics were affected by natural factors mainly in the rest of the microenvironments, which were subjected to low levels of anthropogenic intervention. The heterogeneous structure of the park, as represented by the various microenvironments, offered new habitats and promoted the preservation of natural vegetation. | Pariente SARAH Helena Michaela ZHEVELEV Atar OZ | 2015 | Pedosphere2015，25，3： | 4 |
| 3 | Imaging resolution of biocatalytic activity using nanoscale scanning electrochemical microscopy显示文摘扫描电气化学的显微镜学代表一个强大的工具因为表面的电镀物品(化学药品) 描述,而是它的适用性在 microscale 在大多数情况中被限制了空间分辨率,和最大的挑战是为制造和纳米大小的尖端的使用按比例缩小到 nanoscale。这里,有纳米 electroactive 区域的磅 nanoelectrodes 为成像被制作并且采用金 nanoparticles (AuNPs ) 和在金表面上使不能调动的氧化还原作用活跃的酶的 bioelectrocatalytic 活动的分布。 | Jase M .Abad Alvaro Y. Tesio EmUiano Martinez-Perinan Felix Pariente Encamacion Lorenzo | 2018 | Nano Research2018，11，8： | 2 |
| 4 | Peptic ulcer disease: one in five is related to neither H elicobacter pylori nor aspirin/NSAID intake显示文摘 | C. Charpignon B. Lesgourgues A. Pariente S. Nahon A. Pelaquier G. Gatineau‐Sailliant A.‐M. Roucayrol A. Courillon‐Mallet | 2013 | Aliment Pharmacol Ther2013，，8： | 2 |
| 5 | Trough levels and antibodies to infliximab may not predict response to intensification of infliximab therapy in patients with inflammatory bowel disease显示文摘 | Benjamin Pariente Guillaume Pineton de Chambrun Roman Krzysiek Marine Desroches Gauthier Louis Chiara De Cassan Clotilde Baudry Jean‐Marc Gornet Pierre Desreumaux Dominique Emilie Jean‐Frédéric Colombel Matthieu Allez | 2011 | Inflamm Bowel Dis2011，，7： | 2 |
| 6 | Review article: why, when and how to de‐escalate therapy in inflammatory bowel diseases显示文摘 | B. Pariente D. Laharie | 2014 | Aliment Pharmacol Ther2014，，4： | 2 |
| 7 | Mechanical evaluation of various suburethral tapes used for the treatment of stress urinary incontinence 显示文摘 | Pariente J L Villars F Bram R | 2005 | Prog Urol2005，15，6： | 1 |
| 8 | Selective synthesis of glycerol monolaurate with zeolitic molecular sieves显示文摘 | M da S Machado J P6rez - Pariente E Sastre | 2000 | Applied Catalysis A : General2000，203，2： | 1 |
| 9 | Thrombin induces ac- tivation and translocation of Bid, Bax and Bak to the mitochondria in human platelets 显示文摘 | LOPEZ JJ SALIDO GM PARIENTE JA | 2008 | Journal of Thrombosis and Haemostasis2008，6，10： | 1 |
| 10 | Diaphragmatic paralysis in children:diagnosis by TM - mode ultrasound 显示文摘 | Urvoas E Pariente D Fausser C | 1994 | Pediatr Radiol1994，24，8： | 1 |
| 11 | Criticalanalysis of risk factors and outcome of placenta previa 显示文摘 | ROSENBERG T’PARIENTE G SERGIENKO R | 2011 | Arch Gynecol Obstet2011，284，1： | 1 |
| 12 | Placental abruption:critical analysis of risk factors and perinatal outcomes显示文摘 | Pariente G Wiznitzer A Sergienko R | 2011 | J Matern Fetal Neonatal Med2011，24，5： | 1 |
| 13 | Biometry of the infrarenal inferior vena cava measured by computed tomography显示文摘 | Ph Bonnichon F Gaudard B Lecam J Shilder D Pariente P O Sarfati Y Chapuis | 1992 | Surgical and Radiologic Anatomy1992，，3： | 1 |
| 14 | Role of mitochondria in Ca2+ oscillations and shape of Ca2+ signals in pancreatic acinar cells显示文摘 | Camello-Almaraz C Salido G M Pariente J A | 2002 | Biochem Pharmacol2002，63，2： | 1 |
| 15 | A longitudinal fMRI study:in recovering and then in clinically stable sub-cortical stroke patients显示文摘 | Tombari D Loubinoux I Pariente J | 2004 | Neuroimage2004，23，： | 1 |
| 16 | Cord blood adiponectin in large-for-gestational age newborns显示文摘 | Mazaki Tovi S Kanety H Pariente C | 2005 | Am J Obstet Gynecol2005，193，32： | 1 |
| 17 | Alzheimer's patients engage an alternative network during a memory task显示文摘 | PARIENTE J COLE S HENSON R | 2005 | Ann Neurol2005，58，6： | 1 |
| 18 | Pla- cental abmption:critical analysis of risk factors andperinatal outcomes 显示文摘 | Pariente G Wiznitzer A Sergienko R | 2011 | J Matem Fetal Neonatal Med2011，24，5： | 1 |
| 19 | Treatment of a wastewater from a pesticide manufacture by combined coagulation and Fenton oxidation显示文摘 | PLIEGO G ZAZO J A PARIENTE M I | 2014 | Environ Sci Pollut Res2014，21，12： | 1 |
| 20 | A Reputation-based Trust Management System for P2P Networks显示文摘 | Selcuk A Uzun E Pariente M | 2008 | International Journal of Network Security2008，6，3： | 1 |
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