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| 1 | Cardiovascular efficacy and safety of dipeptidyl peptidase-4 inhibitors:A meta-analysis of cardiovascular outcome trials显示文摘BACKGROUND Dipeptidyl peptidase-4(DPP-4)inhibitors are a generally safe and well tolerated antidiabetic drug class with proven efficacy in type 2 diabetes mellitus(T2DM).Recently,a series of large,randomized controlled trials(RCTs)addressing cardiovascular outcomes with DPP-4 inhibitors have been published.AIM To pool data from the aforementioned trials concerning the impact of DPP-4 inhibitors on surrogate cardiovascular efficacy outcomes and on major cardiac arrhythmias.METHODS We searched PubMed and grey literature sources for all published RCTs assessing cardiovascular outcomes with DPP-4 inhibitors compared to placebo until October 2020.We extracted data concerning the following“hard”efficacy outcomes:fatal and non-fatal myocardial infarction,fatal and non-fatal stroke,hospitalization for heart failure,hospitalization for unstable angina,hospitalization for coronary revascularization and cardiovascular death.We also extracted data regarding the risk for major cardiac arrhythmias,such as atrial fibrillation,atrial flutter,ventricular fibrillation and ventricular tachycardia.RESULTS We pooled data from 6 trials in a total of 52520 patients with T2DM assigned either to DPP-4 inhibitor or placebo.DPP-4 inhibitors compared to placebo led to a non-significant increase in the risk for fatal and non-fatal myocardial infarction[risk ratio(RR)=1.02,95%CI:0.94-1.11,I2=0%],hospitalization for heart failure(RR=1.09,95%CI:0.92-1.29,I2=65%)and cardiovascular death(RR=1.02,95%CI:0.93-1.11,I2=0%).DPP-4 inhibitors resulted in a non-significant decrease in the risk for fatal and non-fatal stroke(RR=0.96,95%CI:0.85-1.08,I2=0%)and coronary revascularization(RR=0.99,95%CI:0.90-1.09,I2=0%),Finally,DPP-4 inhibitors demonstrated a neutral effect on the risk for hospitalization due to unstable angina(RR=1.00,95%CI:0.85-1.18,I2=0%).As far as cardiac arrhythmias are concerned,DPP-4 inhibitors did not significantly affect the risk for atrial fibrillation(RR=0.95,95%CI:0.78-1.17,I2=0%),while they were associated with a significant increase in the risk for atrial flutter,equal to 52%(RR=1.52,95%CI:1.03-2.24,I2=0%).DPP-4 inhibitors did not have a significant impact on the risk for any of the rest assessed cardiac arrhythmias.CONCLUSION DPP-4 inhibitors do not seem to confer any significant cardiovascular benefit for patients with T2DM,while they do not seem to be associated with a significant risk for any major cardiac arrhythmias,except for atrial flutter.Therefore,this drug class should not be the treatment of choice for patients with established cardiovascular disease or multiple risk factors,except for those cases when newer antidiabetics(glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors)are not tolerated,contraindicated or not affordable for the patient. | Dimitrios Ioannis Patoulias Aristi Boulmpou Eleftherios Teperikidis Alexandra Katsimardou Fotios Siskos Michael Doumas Christodoulos E Papadopoulos Vassilios Vassilikos | 2021 | World Journal of Cardiology2021，13，10： | 2 |
| 2 | Dynamic singularities in free-floating space manipulators显示文摘 | Dubowsky S Papadopoulos E | 1993 | Journal of Dynamic Systems Measurement and Control1993，115，1： | 1 |
| 3 | Crack identification in frame structures 显示文摘 | Nikolakopoulos P G Katsareas D E Papadopoulos C A | 1997 | Computers and Structures1997，64，14： | 1 |
| 4 | Precision of in vivo spectrophotometric colour evaluation of natural teeth显示文摘 | Karamouzos A Papadopoulos M A Kolokithas G Athanasiou A E | 2007 | J Oral Rehabil2007，34，： | 1 |
| 5 | On point-to-point motion planning for underactuated space manipulator systems显示文摘 | TORTOPIDIS I PAPADOPOULOS E | 2007 | Robotics and Autonomous Systems2007，55，2： | 1 |
| 6 | On the nature of control algorithms for free-floating space manipulators显示文摘 | Papadopoulos E G Dubowsky S | 1991 | IEEE Transactions on Robotics and Automation1991，7，6： | 1 |
| 7 | Dynamics of pseudo-rigid ball impact on rigid foundation显示文摘 | Kanso E Papadopoulos P | 2004 | International Journal of Non-Linear Mechanics2004，39，2： | 1 |
| 8 | On the nature of control algorithms for free-floating space manipulators 显示文摘 | Papadopoulos E G Dubwsky S | 1991 | IEEE Transactions on Robotics and Automation1991，7，6： | 1 |
| 9 | Perioperative infusion of low dose of vasopressin for prevention and management of vasodilatory vasoplegic syndrome in patients undergoing coronary artery bypass grafting-A double-blind randomized study显示文摘 | Papadopoulos G Sintou E Siminelakis S | 2010 | J Cardiothorac Surg2010，5，： | 1 |
| 10 | Delayed anti-nogo-a therapy improves function after chronic stroke in adult rats显示文摘 | Tsai S Y Papadopoulos C M Schwab M E | 2011 | Stroke2011，42，1： | 1 |
| 11 | On point to point motion plan ning for underactuated space manipulator systems显示文摘 | Tortopidis I Papadopoulos E | 2007 | Robotics and Autonomous Systems2007，55，6： | 1 |
| 12 | On the nature of control algorithms for free floating space manipulators显示文摘 | Papadopoulos E G Dubwsky S | | IEEE Transactions on Robotics and Automation0，7，6： | 1 |
| 13 | On-orbit cooperating space robotic servicers handling a passive object 显示文摘 | Rekleitis G Papadopoulos E | 2015 | IEEE Transactions on Aerospace and Electronic Systems2015，51，2： | 1 |
| 14 | Simultaneous determination of terbuthylazine and its major hydroxy and dealkylated metabolites in wetland water samples using solid-phase extraction and high-performance liquid chromatography with diode-array detection 显示文摘 | Papadopoulos N Gikas E Zalidis G | 2007 | Journal of Agricultural and Food Chemistry2007，55，18： | 1 |
| 15 | Pyrolysis of phenylalanine, 3,6-dibenzyl-2,5-piperazinedione, and phenethylamine 显示文摘 | Patterson J M Haidar N F Papadopoulos E P | 1973 | The Journal of Organic Chemistry1973，38，4： | 1 |
| 16 | On point-to-point motion planning for underactuated space manipulator systems 显示文摘 | Tortopidis I Papadopoulos E | 2007 | Robotics and Autonomous Systems2007，55，1： | 1 |
| 17 | The force-angle measure of tipover stability margin for mobile manipulators 显示文摘 | Papadopoulos E Rey D A | 2000 | Vehicle System Dynamics2000，33，1： | 1 |
| 18 | 4EGI-1 targets breast cancer stem cells by selective inhibition of translation that per- sists in CSC maintenance, proliferation and metastasis 显示文摘 | Yi T Kabha E Papadopoulos E | 2014 | On- cotarget2014，5，60： | 1 |
| 19 | The kinematics, dynamics and control of free-flying and free-floating space robotic systems 显示文摘 | Dubowsky S Papadopoulos E | 1993 | 1EEE Transactions on Robotics and Automation (S1042-296X)1993，9，5： | 1 |
| 20 | Generation and Management of Construction and Demolition Waste in Greece-an Existing Challenge显示文摘 | Fatta D Papadopoulos A Avramikos E | 2003 | Resources Conservation and Recycling2003，40，1： | 1 |
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