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| 1 | Association between population vitamin D status and SARS-CoV-2 related serious-critical illness and deaths:An ecological integrative approach显示文摘BACKGROUND Vitamin D population status may have possible unappreciated consequences to the coronavirus disease 2019(COVID-19)pandemic.Αsignificant association between vitamin D sufficiency and reduction in clinical severity and inpatient mortality from COVID-19 disease has recently been shown,while a recent study has claimed lower COVID-19 cases in European countries with a better vitamin D status.Low serum 25-hydroxyvitamin-D[25(OH)D]was identified as an independent risk factor for COVID-19 infection and hospitalization,and administration of 0.532 mg(21280 IU)of calcifediol or 25(OH)D,followed by 0.266 mg on days 3 and 7 and then weekly until discharge or intensive care unit admission significantly reduced the need for intensive care unit treatment.AIM To elucidate the role of vitamin D European population status in the COVID-19 pandemic,data from the Worldometer were analyzed.METHODS Linear regression explored the correlation between published representativestandardized population vitamin D concentrations and the number of total cases/million(M),recovered/M,deaths/M and serious-critically ill/M from COVID-19 for 26 European countries populated>4 M(Worldometer).Life expectancy was analyzed with semi-parametric regression.Weighted analysis of variance/analysis of covariance evaluated serious-critical/M and deaths/M by the vitamin D population status:Deficient<50,insufficient:50-62.5,mildly insufficient>62.5-75 and sufficient>75 nmol/L,while controlling for life expectancy for deaths/M.Statistical analyses were performed in XLSTAT LIFE SCIENCE and R(SemiPar Library).RESULTS Linear regression found no correlation between population vitamin D concentrations and the total cases-recovered/M,but negative correlations predicting a reduction of 47%-64%-80%in serious-critical illnesses/M and of 61%-82%-102.4%in deaths/M further enhanced when adapting for life expectancy by 133-177-221%if 25(OH)D concentrations reach 100-125-150 nmol/L,sustained on August 15,2020,indicating a truthful association.Weighted analysis of variance was performed to evaluate serious-critical/M(r2=0.22)by the vitamin D population status and analysis of covariance the deaths/M(r2=0.629)controlling for life expectancy(r2=0.47).Serious-critical showed a decreasing trend(P<0.001)from population status deficient(P<0.001)to insufficient by 9.2%(P<0.001),to mildly insufficient by 47.6%(P<0.044)and to sufficient by 100%(reference,P<0.001).For deaths/M the respective decreasing trend(P<0.001)was 62.9%from deficient(P<0.001)to insufficient(P<0.001),65.15%to mildly insufficient(P<0.001)and 78.8%to sufficient(P=0.041).CONCLUSION Achieving serum 25(OH)D 100-150 nmol/L(40-60 ng/mL)(upper tolerable daily doses followed by maintenance proposed doses not requiring medical supervision,Endocrine Society)may protect from serious-critical illness/death from COVID-19 disease. | Dimitrios T Papadimitriou Alexandros K Vassaras Michael F Holick | 2021 | World Journal of Virology2021，10，3： | 2 |
| 2 | Phase Ⅱ irial of paclotaxel and cisplatin in metastic and recurrent carcinoma of the uterine cervix显示文摘 | Papadimitriou CA Sarrisk K Moulopoulos L A | 1999 | J C/inic Oncol1999，17，3： | 1 |
| 3 | PhaseⅡirial of paclotaxel and cisplatin in metastic and recurrent carcinoma of the uterine cervix显示文摘 | Sarrisk K Moulopeul06 L A | 1999 | J Clin Oncol1999，17，3： | 1 |
| 4 | The container shipping network design problem with empty container repositioning显示文摘 | Shintani K lmai A Nishimura E Papadimitriou S | 2007 | Transportation Research Part E: Logistics and Transportation Review2007，43，1： | 1 |
| 5 | Antigens and immune responds in Candida albicans infection 显示文摘 | ASHMAN R B PAPADIMITRIOU J M OTT A K | 1990 | Immunol Cell Biol1990，68，1： | 1 |
| 6 | Discovering probiotic microorganisms : In vitro, in vivo, genetic and omies approaches 显示文摘 | PAPADIMITRIOU K ZOUMPOPOULOU G FOLIGNI~ B | 2015 | Frontiers in microbiology2015，6，： | 1 |
| 7 | Matura-tional tempo differences in relation to the timing of the onset of puberty in girls显示文摘 | PANTSIOTOU S PAPADIMITRIOU A DOUROS K | 2008 | Acta Paediatr2008，97，2： | 1 |
| 8 | Chitosan nanoparticles loaded with dorzolamide and pramipexole 显示文摘 | PAPADIMITRIOUS S BIKIARIS D AVGOUSTAKIS K | 2008 | Carbohydr Polym2008，73，1： | 1 |
| 9 | Vascular endothelial growth factor polymorphisms and clinical outcome in patients with metastatic breast cancer treated with weekly docetaxel 显示文摘 | Koutras A K Kotoula V Papadimitriou C | 2014 | Pharmacogenomics J2014，14，3： | 1 |
| 10 | The presence of the mandibular incisive canal: a panoramic radiographic examination显示文摘 | Romanos GE Papadimitriou DE Royer K | 2012 | Implant Dent2012，21，3： | 1 |
| 11 | Pubertal maturation of contemporary Greek boys:No evidence of a secular trend 显示文摘 | PAPADIMITRIOU A DOUROS K KLEANTHOUS K | 2011 | J Adoles Heahh2011，49，4： | 1 |
| 12 | Emergenceof vim-1 metallo-(3-lactamase-producing Escherichiacoli in a neonatal intensive care unit 显示文摘 | Papadimitriou M Voulgari E Ranellou K | 2011 | Microb DrugResist2011，17，1： | 1 |
| 13 | Sexual maturation of Greek boys显示文摘 | PAPADIMITRIOU A STEPHANOU N PAPANTZIMAS K | 2002 | Ann Human Biol2002，29，1： | 1 |
| 14 | Continuous adjoint approach to the Spalart-Allmaras turbulence model for incompressible flows显示文摘 | Zymaris A S Papadimitriou D I Giannakoglou K C | 2009 | Computers & Fluids2009，38，8： | 1 |
| 15 | The service quality expectations in private sport and fitness centers: A reexamination of the factor structure显示文摘 | PAPADIMITRIOU D A KARTEROLIOTIS K | 2000 | Sport Mark Q2000，9，3： | 1 |
| 16 | Blind deconvolution of multi-input single-Output systems with binary sources 显示文摘 | DIAMANTARAS K I PAPADIMITRIOU T | 2006 | IEEE transactions on signal processing2006，54，10： | 1 |
| 17 | Review : Peyer's patches 显示文摘 | HEEL K A MCCAULEY R D PAPADIMITRIOU J M | 1997 | J Gastroenterol Hepatol1997，12，： | 1 |
| 18 | Surgical treatment of renal neoplasmatic thrombi extending into the inferior vena cava显示文摘 | Papadimitriou D K Pitoulias G A Tachtsi M D | 2006 | Ann Vasc Surg2006，20，2： | 1 |
| 19 | Combination of ifosfamide,paclitaxel,and cisplatin for the treatment of metastatic and recurrent carcinoma of the uterine cervix:a phase Ⅱ study of the Hellenic Cooperative Oncology Group显示文摘 | Dimopoulos M A Papadimitriou C A Sarris K | 2002 | Gynecol Oncol2002，85，3： | 1 |
| 20 | Destination personality, affective image, and behavioral intentions in domestic urban tourism 显示文摘 | Papadimitriou D Apostolopoulou A Kaplanidou K | 2013 | Journal of Travel Research2013，，： | 1 |
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