3篇
您的检索式：作者名="PANG Xiuling"
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| 1 | Galectin-3-centered paracrine network mediates cardiac inflammation and fibrosis upon β-adrenergic insult显示文摘Rapid over-activation of β-adrenergic receptors (β-AR) following acute stress initiates cardiac inflammation and injury by activating interleukin-18 (IL-18),however,the process of inflammation cascades has not been fully illustrated.The present study aimed to determine the mechanisms of cardiac inflammatory amplification following acute sympathetic activation.With bioinformatics analysis,galectin-3 was identified as a potential key downstream effector of β-AR and IL-18 activation.The serum level of galectin-3 was positively correlated with norepinephrine or IL-18 in patients with chest pain.In the heart of mice treated with β-AR agonist isoproterenol (ISO,5 mg kg^(-1)),galectin-3 expression was upregulated markedly later than IL-18 activation,and Nlrp3^(-/-)and Il18^(-/-)mice did not show ISO-induced galectin-3 upregulation.It was further revealed that cardiomyocyte-derived IL-18 induced galectin-3 expression in macrophages following ISO treatment.Moreover,galectin-3deficiency suppressed ISO-induced cardiac inflammation and fibrosis without blocking ISO-induced IL-18 increase.Treatment with a galectin-3 inhibitor,but not a β-blocker,one day after ISO treatment effectively attenuated cardiac inflammation and injury.In conclusion,galectin-3 is upregulated to exaggerate cardiac inflammation and injury following acute β-AR activation,a galectin-3 inhibitor effectively blocks cardiac injury one day after β-AR insult. | Guomin Hu Jimin Wu Huijun Gu Xiangning Deng Wenli Xu Shan Feng Shuaixing Wang Yao Song Zhengda Pang Xiuling Deng Aleksandr E.Vendrov Nageswara R.Madamanchi Marschall S.Runge Xinyu Wang Youyi Zhang Han Xiao Erdan Dong | 2023 | Science China(Life Sciences)2023，66，5： | 3 |
| 2 | Query Expansion Based on Semantics and Statistics in Chinese Question Answering System显示文摘In Chinese question answering system, because there is more semantic relation in questions than that in query words, the precision can be improved by expanding query while using natural language questions to retrieve documents. This paper proposes a new approach to query expansion based on semantics and statistics.Firstly automatic relevance feedback method is used to generate a candidate expansion word set. Then the expanded query words are selected from the set based on the semantic similarity and seman-tic relevancy between the candidate words and the original words. Experiments show the new approach is effective for Web retrieval and out-performs the conventional expansion approaches. | JIA Keliang PANG Xiuling LI Zhinuo FAN Xiaozhong | 2008 | Wuhan University Journal of Natural Sciences2008，13，4： | 2 |
| 3 | Synthesis and Characterization of CoAPO-11 Molecular Sieve from a Non-aqueous System显示文摘IntroductionFolowingthesynthesesofaluminophosphatefamilyofmolecularsieves(AlPO4-n)in1982[1],aseriesofMeAPO-n(Me=Mg,Mn,CoorFe,... | JIAO Xiuling, YAO Youwei, PANG Wenqin** and XU Ruren (Department of Chemistry, Jilin University, Changchun, 130023) | 1999 | Chemical Research in Chinese Universities1999，15，2： | 1 |
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