| 1 | Plasma Edge Kinetic-MHD Modeling in Tokamaks Using Kepler Workflow for Code Coupling,Data Management and Visualization显示文摘A new predictive computer simulation tool targeting the development of the H-mode pedestal at the plasma edge in tokamaks and the triggering and dynamics of edge localizedmodes(ELMs)is presented in this report.This tool brings together,in a coordinated and effective manner,several first-principles physics simulation codes,stability analysis packages,and data processing and visualization tools.A Kepler workflow is used in order to carry out an edge plasma simulation that loosely couples the kinetic code,XGC0,with an ideal MHD linear stability analysis code,ELITE,and an extended MHD initial value code such as M3D or NIMROD.XGC0 includes the neoclassical ion-electron-neutral dynamics needed to simulate pedestal growth near the separatrix.The Kepler workflow processes the XGC0 simulation results into simple images that can be selected and displayed via the Dashboard,a monitoring tool implemented in AJAX allowing the scientist to track computational resources,examine running and archived jobs,and view key physics data,all within a standard Web browser.The XGC0 simulation is monitored for the conditions needed to trigger an ELM crash by periodically assessing the edge plasma pressure and current density profiles using the ELITE code.If an ELM crash is triggered,the Kepler workflow launches the M3D code on a moderate-size Opteron cluster to simulate the nonlinear ELM crash and to compute the relaxation of plasma profiles after the crash.This process is monitored through periodic outputs of plasma fluid quantities that are automatically visualized with AVS/Express and may be displayed on the Dashboard.Finally,the Kepler workflow archives all data outputs and processed images using HPSS,as well as provenance information about the software and hardware used to create the simulation.The complete process of preparing,executing and monitoring a coupled-code simulation of the edge pressure pedestal buildup and the ELM cycle using the Kepler scientific workflow system is described in this paper. | J.Cummings A.Pankin N.Podhorszki G.Park S.Ku R.Barreto S.Klasky C.S.Chang H.Strauss L.Sugiyama P.Snyder D.Pearlstein B.Ludascher G.Bateman A.Kritz the CPES Team | 2008 | Communications in Computational Physics2008，4，8： | 1 |
| 2 | 姜黄素类似物EF25-(GSH)_2抗肝癌作用的研究显示文摘在细胞及动物个体水平探讨姜黄素类似物EF25-(GSH)2的抗肝癌作用。用不同浓度的EF25-(GSH)2处理体外培养的肝癌细胞、正常肝细胞以及HepG2荷瘤裸鼠,MTT法检测细胞存活率,电镜及激光共聚焦显微镜观察细胞形态,蛋白质免疫印迹法(Western blot)检测AMPK/Akt/mTOR相关通路蛋白磷酸化水平的变化。结果显示,EF25-(GSH)2对HepG2作用48 h的IC50为7.2μmol/L,对其生长抑制作用明显优于姜黄素及顺铂,且对正常细胞的杀伤作用较小。形态学观察到细胞中有自噬现象的发生。免疫印迹法结果提示,EF25-(GSH)2可能通过AMPK/Akt/mTOR的相关通路抑制肿瘤细胞生长。对肝癌模型裸鼠的实验显示,给药后的肿瘤体积明显缩小。该实验结果证明,EF25-(GSH)2具有良好的作为肝癌治疗药物的开发前景。 | 叶莉莉 周桃 James P.Snyder 傅海安 黄蓓 | 2014 | 中国细胞生物学学报2014，36，9： | 1 |
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