| 4 | Applicability of available methods for incidence estimation among blood donors显示文摘Incidence rates of major transfusion transmissible viral infections have been estimated through widely used seroconversion approaches and recently developed methods.A quality database for blood donors and donations with the capacity to track donation history of each donor is the basis for incidence estimation and many other epidemiological studies.Depending on available data,different ways have been used to determine incidence rates based on conversion from uninfected to infected status among repeat donors.Reports of incidence estimates need to clearly describe specific ways that are used to derive such estimates so that readers can take into account any methodological differences that may exist when they compare incidence estimates from different studies.The recently developed methods,including the sensitive/less sensitive testing strategy for HIV,the NAT yield method and the HBsAg yield method as well as the prevalence-based approaches,are alternative options for estimating incidence,especially in donor populations where seroconversion approaches are not feasible.Their applicability needs to be examined before their use and results derived from these methods need to be reviewed with their assumptions and potential limitations in mind. | Shimian Zou Edward P.Notari IV Roger Y.Dodd | 2010 | 中国输血杂志2010，23，10： | 1 |
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