|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nitrogen fluxes and processes in sandy and muddy sediments from a shallow eutrophic lake显示文摘 | F. van Luijn P.C.M. Boers L. Lijklema J.-P.R.A. Sweerts | 1998 | Water Research1998，，1： | 1 |
| 2 | Mechanical properities of an HSLA bainitic steel subjected to controlled rolling with accelerated cooling显示文摘 | P.C.M. Rodrigues E.V. Pereloma D.B. Santos | 2000 | Materials Science & Engineering A2000，，1： | 1 |
| 3 | Mechanical properities of an HSLA bainitic steel subjected to controlled rolling with accelerated cooling显示文摘 | P.C.M. Rodrigues E.V. Pereloma D.B. Santos | 2000 | Materials Science & Engineering A2000，，1： | 1 |
| 4 | Product personality and its influence on consumer preference显示文摘 | P.C.M. Govers J.P.L. Schoormans | 2005 | Journal of Consumer Marketing2005，，4： | 1 |
| 5 | 地蒽酚治疗银屑病:对68例住院患者的观察 | Kucharekova M. Lieffers L. van de Kerkhof P.C.M. van der ValkP.G.M. 崔荣 | 2005 | 世界核心医学期刊文摘(皮肤病学分册)2005，0，8： | 0 |
| 6 | 脉冲染料激光治疗局限性顽固性斑块状银屑病的有效性:一项比较研究显示文摘Background: Localized chronic plaque psoriasis, resistant to local therapy, may be very hard to treat. The treatment of these lesions with a pulsed dye laser (PDL) has been described before, but a comparative study between the PDL and a potent topical treatment has never been performed. Objectives: To compare the efficacy of the PDL in the treatment of localized, recalcitrant plaque psoriasis with a potent topical therapy, using calcipotriol/betamethasone dipropionate (Dovobet ) as an active comparator. Methods: Eight patients with psoriasis were treated with both PDL(585 nm) and calcipotriol/ betamethasone dipropionate in an open, intrapatient, left-right comparison. A plaque severity score (sum score) and photographs were used to document the course of therapy. Patients reported pain on a visual analogue scale. Results: Both treatments were well tolerated, although one patient left the study due to post-PDL treatment pain. A significant difference in the sum score 12 weeks after treatment was seen in favour of the PDL (62% vs. 19% reduction; P < 0.05). Scores for erythema declined significantly at week 12 in both the PDL and the calcipotriol/betamethasone dipropionate group (P < 0.001). Induration and desquamation scores were significantly reduced at week 12 in the PDL group, without a statistically significant reduction in calcipotriol/betamethasone- treated lesions. The pain scores declined with progressive PDL treatments, although not statistically significantly. Conclusions: PDL treatment might be considered for the treatment of localized, recalcitrant plaque psoriasis, when other topical therapies have failed. | Erceg A. Bovenschen H. J. Van De Kerkhof P.C.M. Seyger M. M. B. 李政霄(译) | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，2，9： | 0 |
| 7 | 2次/d应用钙泊三醇软膏和1次/d短期应用地蒽酚乳膏治疗:一项按日间用药程序指导性治疗寻常型银屑病的随机对照试验显示文摘Background: Calcipotriol has become a first-line treatment for psoriasis. Its efficacy and safety have been shown in many comparative clinical trials carried out in outpatients. In a comparative study in patients visiting the outpatient department once every 14 days, it was shown that calcipotriol was more effective and better tolerated compared with dithranol. Objectives: To compare the clinical efficacy of calcipotriol ointment with that of dithranol cream in a supervised treatment regimen. Methods: In a multicentre randomized controlled trial in six centres in the Netherlands, 106 patients with chronic plaque psoriasis were included, 54 receiving calcipotriol ointment twice daily and 52 dithranol cream once daily. Patients were treated at the day-care centre, using the care instruction principle of daily visits during the first week and twice-weekly visits subsequently for up to 12 weeks. Results: This study failed to prove that calcipotriol is as efficacious as dithranol when used in a day-care setting (noninferiority test). The mean percentage reduction in Psoriasis Area and Severity Index from baseline to end of treatment was 57.0%in the calcipotriol group vs. 63.6%in the dithranol group. However, the two-sided test for superiority indicated no statistically significant difference between the treatment groups (P = 0.39). At the end of treatment, 15%of the patients treated with calcipotriol ointment and 25%of those treated with dithranol cream did not require any further treatment. Although calcipotriol ointment appeared to be more effective during the first 8 weeks, a difference was no longer apparent at 12 weeks. In comparison with the high number of drop-outs due to cutaneous side-effects in the calcipotriol group, the frequency of a tolerable degree of irritation appeared to be higher in patients treated with dithranol. However, concomitant corticosteroid treatment of dithranol irritation in seven patients may have contributed to this difference between both treatments. Moreover, patients receiving therapy with calcipotriol ointment experienced fewer application-related skin and subcutaneous tissue disorders than patients treated with dithranol cream: 21 of 53 (40%) and 37 of 52 (71%), respectively. This difference is statistically significant (P = 0.001). Conclusions: The hypothesis that calcipotriol ointment might be at least as effective as dithranol cream in the day-care setting could not be proven in the present study. Whereas calcipotriol has become a mainstay in the routine outpatient treatment of psoriasis not requiring a day-care setting, dithranol treatment, being difficult as a routine outpatient therapy, has increased efficacy and improved tolerability if the treatment is carried out in a day-care setting. | Van De Kerkhof P.C.M. Van Der Valk P.G.M. Swinkels O.Q.J 周少娜 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，，12： | 0 |
| 8 | 长疗程短波紫外线治疗白癜风对患者生活质量的影响 | Tjioe M. Otero M.E. van de Kerkhof P.C.M. Gerritsen M.J.P. 牛新武 | 2005 | 世界核心医学期刊文摘(皮肤病学分册)2005，0，7： | 0 |
| 9 | 含有卡泊三醇及二丙酸倍他米松的复方制剂可快速有效治疗各种严重程度的寻常型银屑病 | Van De Kerkhof P.C.M Wasel N Kragballe K P.C.M. Van De Kerkhof 潘敏 | 2005 | 世界核心医学期刊文摘(皮肤病学分册)2005，0，10： | 0 |
| 10 | 联合Zenon标签技术和显微映像分析研究正常人和银屑病患者表皮细胞 | Van Duijnhoven M.W.F.M. Van De Kerkhof P.C.M. Pasch M.C. 李政霄 | 2005 | 世界核心医学期刊文摘(皮肤病学分册)2005，0，6： | 0 |
| 11 | 随机对照研究复合制剂卡泊三醇和倍他米松二丙酸盐(Daivobet~/Dovobet~)对银屑病患者生活质量的影响 | Van De Kerkhof P.C.M. 崔荣 | 2005 | 世界核心医学期刊文摘(皮肤病学分册)2005，0，3： | 0 |
| 12 | 慢性瘙痒性皮肤病患者社会心理障碍的患病率和预测 | van Os-Medendorp H. Eland-de Kok P.C.M. GrypdonckM. 刘艳 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，0，11： | 0 |
| 13 | 银屑病患者皮损处CD4^+ CD25^+ Foxp3^+调控T细胞的识别 | Bovenschen H.J. Van Vlijmen-Willems I.M.J.J. Van De Kerkhof P.C.M. Van Erp P.E.J. 张路坤 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，0，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员