|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | TLR signaling that induces weak inflammatory response and SHIP1 enhances osteogenic functions显示文摘Toll-like receptor(TLR)-mediated inflammatory response could negatively affect bone metabolism. In this study, we determined how osteogenesis is regulated during inflammatory responses that are downstream of TLR signaling. Human primary osteoblasts were cultured in collagen gels. Pam3CSK4(P3C) and Escherichia coli lipopolysaccharide(Ec LPS) were used as TLR2 and TLR4 ligand respectively. Porphyromonas gingivalis LPS having TLR2 activity with either TLR4 agonism(Pg1690) or TLR4 antagonism(Pg1449) and mutant E. coli LPS(LPx E/LPx F/WSK) were used. IL-1b, SH2-containing inositol phosphatase-1(SHIP1) that has regulatory roles in osteogenesis, alkaline phosphatase and mineralization were analyzed. 3a-Aminocholestane(3AC) was used to inhibit SHIP1. Our results suggest that osteoblasts stimulated by P3 C, poorly induced IL-1b but strongly upregulated SHIP1 and enhanced osteogenic mediators. On the contrary, Ec LPS significantly induced IL-1b and osteogenic mediators were not induced. While Pg1690 downmodulated osteogenic mediators, Pg1449 enhanced osteogenic responses, suggesting that TLR4 signaling annuls osteogenesis even with TLR2 activity.Interestingly, mutant E. coli LPS that induces weak inflammation upregulated osteogenesis, but SHIP1 was not induced. Moreover, inhibiting SHIP1 significantly upregulated TLR2-mediated inflammatory response and downmodulated osteogenesis. In conclusion, these results suggest that induction of weak inflammatory response through TLR2(with SHIP1 activity) and mutant TLR4 ligands could enhance osteogenesis. | Manoj Muthukuru Richard P Darveau | 2014 | Bone Research2014，2，4： | 2 |
| 2 | Characterization of intrapelvic pressure during ureteropyeloscopy with ureteral access sheaths显示文摘 | Jamil Rehman Manoj Monga Jaime Landman David I Lee Tamer Felfela Marius C Conradie Rajamahanty Srinivas Chandru P Sundaram Ralph V Clayman | 2003 | Urology2003，，4： | 2 |
| 3 | Massive primary chylopericardium in an infant显示文摘 | Anil SR Manoj P Hejmadi A Kumar RK | 2002 | Indian Heart J2002，54，3： | 1 |
| 4 | High-throughput sequencing for biology and medicine显示文摘 | Wendy Weijia Soon Manoj Hariharan Michael P Snyder | 2013 | Molecular Systems Biology2013，22，1： | 1 |
| 5 | Study on the structural, electrical and optical properties of M-doped ZnO films prepared by chemical spray deposition 显示文摘 | Benny Joseph Manoj P K Vaidyan V K | 2006 | Ceramics International2006，32，5： | 1 |
| 6 | Characterization of a polydisperse depletion floceulated emulsion m oseillatory-rheologieal measurements 显示文摘 | Manoj P Fillery-Travis A J Watson A D | 2000 | Colloid Interface Science2000，228，： | 1 |
| 7 | Studies on thestructural, electrical and optical properties of Al-doped ZnO thin films prepared by chemical spray deposition 显示文摘 | BENNY J MANOJ P K VAIDYAN V K | 2005 | Ceramics International2005，32，5： | 1 |
| 8 | The classification systems for tibial plateau fractures : how reliable are they 显示文摘 | Maripuri SN Rao P Manoj - Thomas A | 2008 | Inju- ry2008，39，10： | 1 |
| 9 | Dual control mechanism in a Belousov-Zhabotinskii (B-Z) oscillator with glucose and oxalic acid as a double substrate显示文摘 | Rastogi R P Prem Chand Manoj K Pandey | 2005 | Phys Chem A2005，109，20： | 1 |
| 10 | P2P networking:an information-sharing altemative显示文摘 | Anjana S | 2001 | IEEE Computing Practices2001，34，7： | 1 |
| 11 | Low-cost adsorbents from bio-waste for the removal of dyes from aqueous solution显示文摘 | Manoj Kumar Reddy P Mahammadunnisa Sk Ramaraju B | 2013 | Environ Sci Pollut Res2013，20，6： | 1 |
| 12 | Electrochemical, DNA sensor for Neisseria meningitidis detection 显示文摘 | MANOJ K P PRATIMA R S ASHOK K el al | 2010 | Biosens Bioelect2010，25，12： | 1 |
| 13 | High slew-rate CMOS operational amplifier 显示文摘 | Subramaniam P C Manoj C R | 2003 | Electronics letter 17th2003，39，8： | 1 |
| 14 | Photocatalytic degradation of organic dyes under UV-visible light using capped ZnS nanoparticles 显示文摘 | MANOJ S TARUN J PANDEY O P | 2012 | Solar Energy2012，86，1： | 1 |
| 15 | DEM - Based Modelling of Surface Runoff Using Diffusion Wave Equation显示文摘 | MANOJ K J VIJAY P S | 2005 | Journal ofHydrology2005，302，： | 1 |
| 16 | Hy- drogen sorption in transition metal modified mesoporous ma- terials 显示文摘 | PRASANTH K P RAJ Manoj C BAJAJ H C | 2010 | Int J of Hydrogen Energy2010，35，6： | 1 |
| 17 | High-rate electrochemical partial oxidation of methane in solid oxide fuel cells显示文摘 | Zhongliang Z Yuanbo L Manoj P | 2006 | J Power Sources2006，161，1： | 1 |
| 18 | Absorption of sulfur dioxide into aqueous reactive slurries of calcium and magnesium hydroxide in a stirred cell显示文摘 | Manoj V D Antonie A C M B Vishwas G P | 2001 | Chemical Engineering Science2001，56，3： | 1 |
| 19 | Chloroperoxidase, a janus enzyme显示文摘 | Manoj K M Hager L P | 2008 | Biochemistry2008，47，9： | 1 |
| 20 | Dietary iron supplements and Moringa oleiferaleaves influence the liver hepcidin messenger RNA expression and biochemical indices of iron status in rats显示文摘 | SAINI RK MANOJ P SHETTY NP | 2014 | Nutrition Research2014，34，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员