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| 1 | Survival in gastric cancer in relation to postoperative adjuvant therapy and determinants显示文摘AIM: To evaluate survival data in patients with gastric cancer in relation to postoperative adjuvant therapy and survival determinantsMETHODS: A total of 201 patients(mean ± SD age: 56.0 ± 11.9 years, 69.7% were males) with gastric carcinoma who were operated and followed up at Lutfi Kirdar Kartal Training and Research Hospital between 1998 and 2010 were included in this retrospective study. Follow up was evaluated divided into two consecutive periods(before 2008 and 2008-2010, respectively) based on introduction of 3-D conformal technique in radiotherapy at our clinic in 2008. Data on patient demographics, clinical and histopathological characteristics of gastric carcinoma and the type of treatment applied after surgery [postoperative adjuvant treatment protocols including chemoradiotherapy(CRT) and chemotherapy(CT), supportive therapy or follow up without any treatment] were recorded. The median duration and determinants of local recurrence free(LRF) survival, distant metastasis free(DMF) survival and overall survival were evaluated in the overall population as well as with respect to follow up years [1998-2008(n = 127) vs 2008-2010(n = 74)].RESULTS: Median duration for LRF survival, DMF survival and overall survival were 31.9, 24.1 and 31.9 mo, respectively in patients with postoperative adjuvant CRT. No significant difference was noted in median duration for LRF survival, DMF survival and overall survival with respect to treatment protocols in the overall population and also with respect to followed up periods. In the overall population, CT protocols FUFA [5-fluorouracil(400 mg/m2) and leucovorin-folinic acid(FA, 20 mg/m2)](29.9 mo) and UFT + Antre [a fixed combination of the oral FU prodrug tegafur(flouroprymidine, FT, 300 mg/m2 per day) with FA(Antrex?), 15 mg tablet, two times a day](42.5 mo) was significantly associated with longer LRF survival times than other CT protocols(P = 0.036), while no difference was noted between CT protocols in terms of DMF survival and overall survival. Among patients received CRT, overall survival was significantly longer in patients with negative than positive surgical margin(27.7 mo vs 22.4 mo, P = 0.016) in the overallstudy population, while time of radiotherapy initiation had no significant impact on survival times. Nodal stage was determined to be independent predictor of LRF survival in the overall study population with 4.959 fold(P = 0.042) increase in mortality in patients with nodal stage N2 compared to patients with nodal stage N0, and independent predictor of overall survival with 5.132 fold(P = 0.006), 5.263 fold(P = 0.027) and 4.056 fold(P = 0.009) increase in the mortality in patients with nodal stage N3a(before 2008), N3b(before 2008) and N2(overall study population) when compared to patients with N0 stage, respectively.CONCLUSION: Our findings emphasize the likelihood of postoperative adjuvant CRT to have a survival benefit in patients with resectable gastric carcinoma. | Sevgi Ozden Zerrin Ozgen Hazan Ozyurt Cengiz Gemici Gokhan Yaprak Huseyin Tepetam Alpaslan Mayadagli | 2015 | World Journal of Gastroenterology2015，21，4： | 7 |
| 2 | Prognostic role of sensitive-to-apoptosis gene expression in rectal cancer显示文摘AIM:To investigate the association between prognosis of rectal cancer treated with chemoradiotherapy(CRT) and expression of sensitive-to-apoptosis(SAG),B-cell lymphoma-extra large(Bcl-X L) and Bcl-2 homologous antagonist/killer(Bak).METHODS:Real-time quantitative polymerase chain reaction was used to determine the expression of proteins of interest,namely SAG,Bcl-X L,Bak and β-actin,in rectal carcinoma patients who had a follow-up period of 3 years after CRT.Biopsy specimens were excised from the rectal tumor preceding CRT.RESULTS:SAG,Bcl-X L and Bak proteins showed significant correlations with each other.In multivariate analysis,patients with high vs low SAG expression showed a statistically significant difference in 2-year survival rates:56% vs 73%,respectively(P = 0.056).On the other hand,there were no significant correlations between the expression levels of all three genes and metastatic rates or tumor responses to CRT.Mean overall survival in the patients with elevated SAG expression was 27.1 mo ± 3.9 mo [95% confidence interval(CI):19.3-34.9],and in patients with reduced expression,it was 32.1 mo ± 2.5 mo(95% CI:27.3-36.9).The corresponding values for Bcl-X L were 28.0 mo ± 4.1 mo(95% CI:19.9-36.1) and 31.7 mo ± 2.9 mo(95% CI:26.0-37.5),and those for Bak were 29.8 mo ± 3.7 mo(95% CI:22.5-37.2) and 30.6 mo ± 2.4 mo(95% CI:25.5-35.0),respectively.CONCLUSION:Two-year survival rates significantly correlated with low SAG expression,and SAG may be a candidate gene for good prognosis,independent of therapeutic response of different individuals. | Sevgi A Ozden Hazan Ozyurt Zerrin Ozgen Olca Kilinc Mustafa Oncel Aylin E Gul Nimet Karadayi Nedime Serakinci Beki Kan Oya Orun | 2011 | World Journal of Gastroenterology2011，17，44： | 6 |
| 3 | Significance of mitochondrial activity in neurogenesis and neurodegenerative diseases显示文摘Mitochondria play a multidimensional role in the function and the vitality of the neurological system.From the generation of neural stem cells to the maintenance of neurons and their ultimate demise,mitochondria play a critical role in regulating our neural pathways'homeostasis,a task that is critical to our cognitive health and neurological well-being.Mitochondria provide energy via oxidative phosphorylation for the neurotransmission and generation of an action potential along the neuron's axon.This paper will first review and examine the molecular subtleties of the mitochondria's role in neurogenesis and neuron vitality,as well as outlining the impact of defective mitochondria in neural aging.The authors will then summarize neurodegenerative diseases related to either neurogenesis or homeostatic dysfunction.Because of the significant detriment neurodegenerative diseases have on the quality of life,it is essential to understand their etiology and ongoing molecular mechanics.The mitochondrial role in neurogenesis and neuron vitality is essential.Dissecting and understanding this organelle's role in the genesis and homeostasis of neurons should assist in finding pharmaceutical targets for neurodegenerative diseases. | Serra Ozgen Judith Krigman Ruohan Zhang Nuo Sun | 2022 | Neural Regeneration Research2022，17，4： | 2 |
| 4 | Microanatomy of the central myelin-peripheral myelin transition zone of the trigeminal nerve显示文摘 | ZIYAL I M OZGEN T | 2007 | Neurosurgery2007，60，： | 1 |
| 5 | Biological denitrification in drinking water using Glycyrrhiza glabra and Arunda donax as t he carbon source显示文摘 | Oyez B Ozgen S Yuksel M | 2006 | Process Biochemistry2006，41，： | 1 |
| 6 | Spinal dural arteriovenous fistula andvenous aneurysm:an unusual ssociation显示文摘 | Inci S Akdemir P Ozgen T | 2003 | Surg Neurol2003，60，4： | 1 |
| 7 | Antibacterial, antifungal, and antiviral activities of some flavonoids显示文摘 | Orhan D D Ozcelik B Ozgen S | 2010 | Microbiological Research2010，165，6： | 1 |
| 8 | Serum adiponectin and vaspin levels in rheumatoid arthritis显示文摘 | Ozgen M Koca SS Dagli N | 2010 | Arch Med Res2010，41，6： | 1 |
| 9 | Comparison of shaped-charge perforating induced formation damage to gas and liquid-saturated sandstone samples显示文摘 | KARACAN C Ozgen HALLECK P M | 2003 | Journal of Petroleum Science and Engineering2003，40，3： | 1 |
| 10 | Mechanical behavior PBXW-128 and PBXN-110 under uniaxial and multiaxial compression at different strain rates and temperatures显示文摘 | Ozgen U C | 2004 | Turkish Journal of Engineering and Environmental Sciences2004，5565，： | 1 |
| 11 | Validity and reliability of 'Asthma Quality of Life Questionnaire' in a sample of Turkish adult asthmatic patients显示文摘 | Ozgen AA Yorgancioglu A Yilmaz O | 2011 | Tuberk Toraks2011，59，4： | 1 |
| 12 | Outcomes for combined anterior and posterior surgical approaches for patients with muhisegmental cervical spondylotic myelopathy 显示文摘 | Konya D Ozgen S Gercek A | 2009 | Journal of Clinical Neuro- science2009，16，3： | 1 |
| 13 | Vitamin D deficiency andinsufficiency in obese children and adolescents and its relationshipwith insulin resistance显示文摘 | Torun E GCniillii E Ozgen IT | 2013 | Int J Endocrinol2013，2013，63： | 1 |
| 14 | Vitamin d deficiency and insufficiency in obese children and adolescents and its relationship with insulin resistance显示文摘 | Torun E Gonullu E Ozgen IT | 2013 | Int J Endocrinol2013，2013，63： | 1 |
| 15 | Vascular injuries and amputation following limb fractures 显示文摘 | EREN N OZGEN G GUREL A | 1990 | Thorac Cardiovasc Surg1990，38，： | 1 |
| 16 | Meningiomas of the lateral ventricle: report on six cases 显示文摘 | Caner H Acikgoz B Ozgen T | 1992 | Neurosurg Rev1992，15，： | 1 |
| 17 | Cervical spondylotic myelopathy: surgical results and factors affecting prognosis 显示文摘 | Naderi S Ozgen S Pamir MN | 1998 | Neurosurg1998，43，1： | 1 |
| 18 | Is Color 'Categorical Perception' Really Perceptual 显示文摘 | Pilling M Wiggett A Ozgen E | 2003 | Mem Cognit2003，31，4： | 1 |
| 19 | Biological denitrification in drinking water using Glycyrrhiza glabra and Arundo donax as the carbon source显示文摘 | Oyez B Ozgen S Yuksel M | 2006 | Process Biochemistry2006，41，7： | 1 |
| 20 | Development of geothermal energy utilization in Turkey:A review显示文摘 | Hepbasli A Ozgener L | 2004 | Renewable and Sustainable Energy Reviews2004，8，5： | 1 |
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