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| 1 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 2 | Fluorescent proteins as biomarkers and biosensors: throwing color lights on molecular and cellular processes 显示文摘 | Stepanenko OV Verkhusha VV Kuznetsova IM | 2008 | Curr Protein Pept Sci2008，9，4： | 1 |
| 3 | Molecular causes of colon cancer显示文摘 | Oving IM Clevers HC | 2002 | Eur J Clin Invest2002，32，6： | 1 |
| 4 | The factor of intra- abdominal pressure in patients with morbid obesity显示文摘 | Todurov IM Bilians'ky LS Perekhristenko OV | 2013 | Klin Khir2013，5，： | 1 |
| 5 | Molecular causes of colon cancer显示文摘 | Oving IM Clevers HC | 2002 | Eur J Clin Invest2002，32，6： | 1 |
| 6 | Molecular causes of colon cancer显示文摘 | Oving IM | 2002 | Eur Clin Invest2002，32，6： | 1 |
| 7 | Molecular causes of colon cancer显示文摘 | Oving IM Clevers HC | 2002 | Clin Invest2002，32，6： | 1 |
| 8 | The factor of intra-abdominal pressure in patients with morbid obesity 显示文摘 | Todurov IM Bilians'ky LS Perekhristenko OV | 2013 | Klin Khir2013，，5： | 1 |
| 9 | Molecular causes of colon cancer 显示文摘 | Oving IM Clevers HC | 2002 | Eur J Clin Invest2002，32，6： | 1 |
| 10 | Inherited glaucoma in DBA/2J mice:pertinent disease features for studying the neurodegeneration 显示文摘 | Libby RT Anderson MG Pang IH Robinson ZH Savinova OV Cosma IM | 2005 | Vis Neurosci2005，22，5： | 1 |
| 11 | Modulation of histam ine H3 recep to rs in the brain of 62hydroxydopam ine21esioned rats 显示文摘 | Anichtchik OV Huotar IM Peitsar ON | 2000 | Eur J Neu2rosc i2000，12，11： | 1 |
| 12 | Heat shock proteins and their role in the development of pathological processes显示文摘 | Malaǐtsev VV Bogdanova IM Makarova OV | 2008 | Arkh Patol2008，70，6： | 1 |
| 13 | Fluorescent proteins as biomarkers and biosensors: throwing color lights on molecular and cellular processes显示文摘 | Stepanenko OV Verkhusha VV Kuznetsova IM | 2008 | Curt Protein Pept Sci2008，9，4： | 1 |
| 14 | Molecular causes of colon cancer European显示文摘 | Oving IM Clevers HC | 2002 | J ClinInvest2002，32，： | 1 |
| 15 | The place of inactivated actin and its kinetic predecessor in actin folding - unfolding显示文摘 | Kuznetsova IM Stepanenko OV Stepanenko OV | 2002 | Biochemistry2002，41，13： | 1 |
| 16 | Molecular causes of colon cancer显示文摘 | Oving IM Clevers HC | 2002 | EurJ Clin Invest2002，32，6： | 1 |
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