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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | Model Analysis of Corn Response to Applied Nitrogen and Plant Population Density显示文摘 | Overman A R Schohz III R V Brock K H | 2006 | Communications in Soil Science and Plant Analysis2006，37，10： | 1 |
| 3 | Estimation of yield and nitrogen removal by corn显示文摘 | Overman A R Wilson D M Kampprath E J | 1994 | Agronomy Journal1994，86，： | 1 |
| 4 | Contiguous stereogenlc quaternary carbons: A daunting challenge in natural products synthesis 显示文摘 | Peterson E A Overman L E | 2004 | Proc Natl Acad Sci USA2004，101，11： | 1 |
| 5 | Microsporidiosis myositis in a patient with the acquired immunedeficiency syndrome显示文摘 | Ledford DK Overman MD Gonzalvo A | 1985 | Ann Intern Med1985，102，5： | 1 |
| 6 | Frontage roads:assessment of legal issues,design decisions,costs,operations,and land-development differences显示文摘 | Kockelman K M Machemehl R Overman A W | 2003 | J Transp Eng-ASCE2003，，3： | 1 |
| 7 | Quercetin attenuates inflammation in human macrophages and adipocytes exposed to macrophage-conditioned media显示文摘 | Overman A Chuang C C Mclntosh M | 2011 | Int J Obes2011，35，9： | 1 |
| 8 | The asymmetric intermolecular heck reaction in natural product total synthesis显示文摘 | Dounay A B Overman L E | 2003 | Chem Rev2003，103，： | 1 |
| 9 | Raman spectroscopy of the filamentous virus Ff(fd, f1, M13): structural interpretation for coat protein aromatics显示文摘 | OVERMAN S A THOMAS jr G J | 1995 | Biochemistry1995，34，： | 1 |
| 10 | The asymmetric intramolecular Heck reaction in natural product total synthesis显示文摘 | ounay A B Overman L E | 2003 | Chem Rev2003，103，： | 1 |
| 11 | Economic linkages across space显示文摘 | Overman H G Rice P Venables A J | 2010 | Regional Studies2010，44，1： | 1 |
| 12 | CRF induces intestinal epithelial barrier injury via the re- lease of mast cell proteases and TNF-alpha 显示文摘 | OVERMAN E L RIVIER J E MOESER A J | 2012 | PLoS One2012，7，39： | 1 |
| 13 | Model for accumulation of dry matter and plant nutrient elements by tobacco 显示文摘 | OVERMAN A R | 1999 | Journal of Plant Nutrition1999，22，1： | 1 |
| 14 | Vinylsilane-and alkylnylsilane-terminated cyclization reactions显示文摘 | BLUMENKOPF T A OVERMAN L E | 1986 | Chem Rev1986，86，： | 1 |
| 15 | Model for accumulation of dry matter and plant nutrients by corn 显示文摘 | OVERMAN A R SCHOLTZ R V | 1999 | Communications in Soil Science and Plant Analysis1999，30，15： | 1 |
| 16 | Prognostic value of lymph node evaluation in small bowel adenocarcinoma: analysis of the surveillance, epidemiology, and end results database 显示文摘 | OVERMAN M J HU C WOLFF R A | 2010 | Cancer2010，116，23： | 1 |
| 17 | The economic geography of trade, production and income: A survey of empirics 显示文摘 | Overman H G Redding S Venables A J | 2001 | Journal of Industry2001，85，9： | 1 |
| 18 | Enantioselective total synthesis of Shahamin K显示文摘 | LEBSACK A D OVERMAN L E VALENTE-KOVICH R J | 2001 | J Am Chem Soe2001，123，： | 1 |
| 19 | Chloramphnical effect on DNA structure显示文摘 | Thomas Jr G Benevides J M Overman S A | 1995 | Biophys1995，68，： | 1 |
| 20 | Uniqueness of flow of a second-order fluid past a stretching sheet显示文摘 | Troy W Overman Ⅱ E A Ennentrout G B | 1987 | Quart Appl Math1987，44，4： | 1 |
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