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| 1 | Thermally controlled association in aqueous solutions of diblock copolymers of poly and poly(N-isopropylacrylamide)显示文摘 | Konak C Oupicky D Chytry V | 2000 | Macromolecules2000，33，15： | 1 |
| 2 | Methodologies for monitoring nanoparticle formation by self-assembly of DNA with poly(L-lysine) 显示文摘 | Parker A L Oupicky D Dash P R | 2002 | Anal Biochem2002，302，1： | 1 |
| 3 | Methodologies for monitoring nanoparticles formation by self-assembly of DNA with poly(1- lysine) 显示文摘 | Parker AL Oupicky D Dash PR | 2001 | Anal Biochem2001，302，1： | 1 |
| 4 | Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate- mediated targeting in vitro and prolonged plasma circulation in vivo 显示文摘 | Ward CM Pechar M Oupicky D | 2002 | J Gene Med2002，4，5： | 1 |
| 5 | A networked swellable dextrin nanogels loading Bcl2 siRNA for melanoma tumor therapy显示文摘在这研究,联网的可胀大的糊精 nanogel (DNG ) 被开发完成刺激应答的小介入为黑瘤肿瘤的 RNA (siRNA ) 版本治疗。siRNA 被费用冷凝作用装进多维的糊精 nanogels,积极精氨酸残余在糊精脊梁修改了。而且,联网的 nanogel 被破坏并且基于它的 bioreducible 松开了应答的性质在 bioreducible 控制加速的 siRNA 版本细胞内部的环境,当它在正常生理的条件下面仍然保持稳定时。我们由传播电子显微镜学评估在减少的缓冲区状况下面表明了可胀大的有的那 DNG 和拆卸性质。DNG 完成了被触发谷胱甘肽的拆卸货物的选择版本根据共焦的显微镜学观察跟随进 cytosol 的 endosomal 逃跑。因此,这聪明的 nanogel 完成了突出的酶基因 silencing 效率并且减少在 vitro 并且在 vivo 的 Bcl2 蛋白质表示基于西方的污点分析。而且,这 nanogel 在 C57BL/6 老鼠为 B16F10 异种皮移植肿瘤展出了优异反肿瘤活动。这些结果证明联网的 DNG 为基因冷凝作用是有效的并且为肿瘤治疗控制细胞内部的版本。总的来说,这些调查结果建议这多维的可胀大的刺激应答的糊精 nanogel 是有为基因和药交货的大诺言的创新策略。 | Huipeng Li Zhanwei Zhou Feiran Zhang Yuxin Guo Xue Yang Hulin Jiang Fei Tan David Oupicky Minjie Sun | 2018 | Nano Research2018，11，9： | 1 |
| 6 | Methodologies for monitoring nanoparticales formation by self-assembly of DNA with poly (L-Lysine)显示文摘 | Parker A L Oupicky D | 2002 | An Bioehem2002，302，1： | 1 |
| 7 | Physical properties and in vitro trasfection efficiency of gene delivery vectors based on complexes of DNA with synthetic polycations显示文摘 | Reschel T Konak C Oupicky D etal | 2002 | J Control Release2002，81，12： | 1 |
| 8 | Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation显示文摘 | Oupicky D Ogris M Howard K A | 2002 | Molecular therapy:the journal of the American Society of Gene Therapy2002，5，4： | 1 |
| 9 | Physical properties and in vitro transfection efficiency of gene delivery vectors based on complexes of DNA with synthetic polycations 显示文摘 | Reschel T Konak C Oupicky D | 2002 | J Control Release2002，81，12： | 1 |
| 10 | Laterally stabilized complexes of DNA with linear reducible polycations: strategy for triggered intracellular activation of DNA delivery vectors显示文摘 | Oupicky D Parker A L Seymour L W | 2002 | Jam Chem Soc2002，124，1： | 1 |
| 11 | Temperature-controlled behavior of self-assembly gene delivery vectors based on complexes of DNA with poly(L-lysine)-graft-poly(N-isopropylacrylamide)显示文摘 | Oupicky D Reschel T Konak C | 2003 | Macromolecules2003，36，18： | 1 |
| 12 | 查看详情显示文摘 | Yuan J.C You Y.Z Lu X Muzik O. Oupicky D. Peng F.Y | | 0，，： | 1 |
| 13 | Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation显示文摘 | Oupicky D Ogris M Seymour LW | 2002 | Mol Ther2002，5，： | 1 |
| 14 | Modification of pLL/DNA complexes with a multivalent hydrophilic polymer permits folate-mediated targeting in vitro and prolonged plasma circulation in vivo显示文摘 | Ward CM Pechar M Oupicky D | 2002 | J Gene Med2002，4，5： | 1 |
| 15 | Seymour,Modification of pLL/DNA complexes with a multivalenthydrophilic polymer permits folate-mediated targeting in vitro and prolonged plasma circulation in vivo 显示文摘 | Pechar M Oupicky D | 2002 | J Gene Med2002，4，： | 1 |
| 16 | Development of fluorinated polyplex nanoemulsions for improved small interfering RNA delivery and cancer therapy显示文摘我们基于 cationic perfluorocarbon nanoemulsions 报导小介入 RNA (siRNA ) 交货向量的发展。我们准备了有积极表面费用的乳剂提供了由的 perfluorodecalin (PFD ) 一 poly 氟化(ethylenimine )(F-PEI ) 。氟化的乳剂(F-PEI@PFD ) 减少了 F-PEI 的 cytotoxicity 并且与 siRNAs 表明了有效绑定形成 nanosized 乳剂 polyplexes。提高的细胞的举起和改进 endosomal siRNA 逃离的准备乳剂 polyplexes。,除了在多重癌症的增加的记者基因 silencing,房间与控制 F-PEI 和 PEI polyplexes 相比排队, siRNA 乳剂 polyplexes 显示出一个优秀电阻到浆液释放并且维持了高活动,甚至处于高浆液的条件。带 siRNA 到 Bcl2 基因的表达式导致了的沉默的 F-PEI@PFD 乳剂 polyplexes 在一个黑瘤鼠标的 apoptosis 和禁止的肿瘤生长在 vivo 和显示出的潜力当模特儿为在 vivo 超声成像。这研究为安全 siRNA 交货作为多功能的 theranostic nanoplatform 表明 F-PEI@PFD 乳剂的潜力,与综合超声成像功能。 | Gang Chen Kaikai Wang Pengkai Wu Yixin Wang Zhanwei Zhou Lifang Yin Minjie Sun David Oupicky | 2018 | Nano Research2018，11，7： | 1 |
| 17 | Methodologies for monitoring nanoparticles formation by self-assembly of DNA with poly(L-Lysine)显示文摘 | Oupicky D Dash PR | 2002 | Anal Biochem2002，302，1： | 1 |
| 18 | DNA delivery systems based on complexes of DNA with synthetic polycations and their copolymers显示文摘 | OUPICKY D KONAK C ULBRICH K | 2000 | J Control Release2000，65，12： | 1 |
| 19 | DNA delivery systems based on complexes of DNA with synthetic polycations and their copolymers 显示文摘 | Oupicky D Konak C Ulbrich D | 2000 | J Control Release2000，65，： | 1 |
| 20 | Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for ex-tended systemic circulation显示文摘 | Oupicky D Ogris M Howard KA | | 0，，04： | 1 |
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