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| 1 | Lactobacillus bulgaricus inhibits colitis-associated cancer via a negative regulation of intestinal inflammation in azoxymethane/dextran sodium sulfate model显示文摘BACKGROUND Colitis-associated cancer(CAC)accounts for 2%-3%of colorectal cancer(CRC)cases preceded by inflammatory bowel diseases(IBD)such as Crohn's disease and ulcerative colitis.Intestinal microbiota has been reported to play a central role in the pathogenesis of IBD and CAC.Recently,numerous prebiotics and probiotics have being investigated as antitumor agents due to their capacity to modulate inflammatory responses.Previous studies have indicated that lactic acid bacteria could be successfully used in managing sporadic CRC,however little is known about their role in CAC.AIM To investigate the effect of the probiotic Lactobacillus bulgaricus(L.bulgaricus)during the development of an experimental model of colitis associated colon cancer(CAC).METHODS C57BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg),followed by three cycles of sodium dextran sulphate diluted in water(5%w/v).Probiotic group received daily L.bulgaricus.Intestinal inflammation was determined by scoring clinical signs.Cytokines levels were determined from colon and/or tumor samples by ELISA BD OptEIATM kits.The level of significance was set at P<0.05.Graphs were generated and statistical analysis performed using the software GraphPad Prism 6.0.RESULTS L.bulgaricus treatment inhibited of total tumor volume and mean size of tumors.In addition,the probiotic also attenuated the clinical signs of intestinal inflammation inducing a decrease in intestinal and tumor levels of IL-6,TNF-α,IL-17,IL-23 and IL-1β.CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC.L.bulgaricus regulates the inflammatory response and preventing CAC. | Denise Sayuri Calheiros Silveira Luciana Chain Veronez Luis Carlos Lopes-Junior Elen Anatriello Mariangela Ottoboni Brunaldi Gabriela Pereira-da-Silva | 2020 | World Journal of Gastroenterology2020，26，43： | 3 |
| 2 | Endoscopic sleeve gastroplasty:a narrative review on historical evolution,physiology,outcomes,and future standpoints显示文摘Since its first description in 2013,robust evidence supporting the efficacy and safety of the endoscopic sleeve gastroplasty(ESG)has been on the rise.A large case series and meta-analysis report supported results up to 24 months,while some other studies already described 5-year data.If associated with pharmacotherapy,the ESG may help one to achieve weight loss similar to that of surgical sleeve gastrectomy.Though the results of the ongoing randomized trials on ESG are awaited,currently available data support the clinical use of the ESG,especially for patients who are refusing or unfit for bariatric surgery. | Vitor Ottoboni Brunaldi Manoel Galvao Neto | 2022 | Chinese Medical Journal2022，，7： | 2 |
| 3 | Genetic distanceof inbred lines and prediction of maize single-cross performance u-sing RAPD markers显示文摘 | Lanza L L B Souza C L Ottoboni L M M | 1997 | Theoretical and Applied Genetics1997，94，： | 1 |
| 4 | Phlebitis in amiodarone administration: Incidence,contributing fac- tors,and clinical implications显示文摘 | Norton L Ottoboni LK Varady A | 2013 | Am J Crit Care2013，22，6： | 1 |
| 5 | Proce- ssing magnetic sensor array data for AC current measurement in multiconductor systems 显示文摘 | Gabriele D' Antona Luca Di Rienzo Roberto Ottoboni | 2001 | IEEE Transactions on Instrumenta- tion and Measurement2001，50，5： | 1 |
| 6 | RhoA and zeta PKC control distinct modalities of LFA-1 activation by chemokines:critical role of LFA-1 affinity triggering in lymphocyte in vivo homing显示文摘 | Giagulli C Scarpini E Ottoboni L | 2004 | Immunity2004，20，1： | 1 |
| 7 | High accuracy Fourier analysis based on synchronous sampling techniques 显示文摘 | FERRERO A OTTOBONI R | 1992 | IEEE Trans Instrum Meas1992，41，6： | 1 |
| 8 | Thiobacillus ferrooxidans response to copper and other heavy metals: growth, protein synthesis and protein phosphorylation显示文摘 | NOVO M T DA SILVA A C MORETO R CABRAL P C COSTACURTA A GARCIA O Jr OTTOBONI L M | 2000 | Antonie van Leeuwenhoek2000，77，： | 1 |
| 9 | Preoperative rectal tumor embolization as an adjunctive tool for bloodless abdominoperineal excision:A case report显示文摘BACKGROUND Abdominoperineal excision(APE)-related hemorrhage can be challenging due to difficult access to pelvic organs and the risk of massive blood loss.The objective of the present study was to demonstrate the use of preoperative embolization(PE)as a strategy for blood preservation in a patient with a large low rectal tumor with a high risk of bleeding,scheduled for APE.CASE SUMMARY A 56-year-old man presented to our institution with a one-year history of anal bleeding and rectal tenesmus.The patient was diagnosed with bulky adenocarcinoma limited to the rectum.As the patient refused any clinical treatment,surgery without previous neoadjuvant chemoradiation was indicated.The patient underwent a tumor embolization procedure,two days before surgery performed via the right common femoral artery.The tumor was successfully devascularized and no major bleeding was noted during APE.Postoperative recovery was uneventful and a one-year follow-up showed no signs of recurrence.CONCLUSION Therapeutic tumor embolization may play a role in bloodless surgeries and increase surgical and oncologic prognoses.We describe a patient with a bulky low rectal tumor who successfully underwent preoperative embolization and bloodless abdominoperineal resection. | Marley Ribeiro Feitosa Lucas Fernandes de Freitas Antonio Balestrim Filho Guilherme Seizem Nakiri Daniel Giansante Abud Ligia Magnani Landell Mariângela Ottoboni Brunaldi Jose Joaquim Ribeiro da Rocha Omar Feres Rogério Serafim Parra | 2020 | World Journal of Clinical Oncology2020，11，12： | 1 |
| 10 | Articular surface approximation in equivalent spatialparallel mechanism models of the human knee joint: Anexperiment-based assessment显示文摘 | OTTOBONI A PARENTI C V SANCISI N | 2010 | Proceedings of theInstitution of Mechanical Engineers Part H: Journal ofEngineering in Medicine2010，224，9： | 1 |
| 11 | A simple method for the calibration of traditional and electronic measurement current and voltage transformers显示文摘 | Amaldo Brandolini Marco Failer Roberto Ottoboni | 2009 | IEEE Transactions on Instrumentation and Measurement2009，58，5： | 1 |
| 12 | HPV16-E6 enhances mitoxantrone sensitivity in a human ovarian cancer line:an isolated instance or a trend?显示文摘 | Cimoli G Valenti M Ottoboni C | 2001 | Int J Oncol2001，18，4： | 1 |
| 13 | Phlebitis in amiodarone administration: incidence, contributing fac- tors, and clinical implications显示文摘 | Norton L Ottoboni L K Varady A | 2013 | Am J Crit Care2013，22，6： | 1 |
| 14 | HPV16-E6 enhances mitoxantrone sensitivity in a human ovarian cancer line: An isolated instance or a trend? 显示文摘 | Cimoli G Valenti M Ottoboni C | 2001 | Int J Oncol2001，18，4： | 1 |
| 15 | A low-cost frequency multiplier for synchronous sampling of periodic signals显示文摘 | Ferrero Alessandro Ottoboni Roberto | 1992 | IEEE Trans on Instrumentation and Measurement1992，41，2： | 1 |
| 16 | Characterization of the storage protein in seed of Coix lacrymajobi var adlay显示文摘 | OTTOBONI L M M LEITE A TARGON M L N | 1990 | Journal of Agricultural and Food Chemistry1990，38，3： | 1 |
| 17 | A low cost frequency multiplier for syn chronous sampling of periodic signals显示文摘 | Alessandro Fcrrero Roberto Ottoboni | 1992 | IEEE Transactions on Instrumentation and Measurement1992，41，2： | 1 |
| 18 | Electronic combined transformer for power-quality measurements in high-voltage systems显示文摘 | Marco Faifer Sergio Toscani Reberto Ottoboni | 2011 | IEEE Transactions on Instrumentation and Measurement2011，60，6： | 1 |
| 19 | Protein profile of Acidithiobacillus fertooxidans exhibiting differeent levels of tolerance to metal sulfates显示文摘 | Novo M T Garcia J O Ottoboni L M | 2003 | Current Microbiology2003，47，： | 1 |
| 20 | Thiobacillus ferrooxidans response to copper and other heavy metals:Growth,protein synthesis and protein phosphorylation显示文摘 | NOVO M T DA SILVA A C MORETO R CABRAL P C COSTACURTA A GARCIAO JR & OTTOBONI L M | 2000 | Antonie van Leeuwenhoek2000，77，： | 1 |
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