|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Isolation and Identification of Bioactive Constituents from Stem Barks of Illicium difengpi显示文摘Objective To isolate and identify bioactive constituents from the stem barks of Illicium difengpi.Methods The chemical constituents were isolated and purified by repeated silica gel,Sephadex LH-20,recrystallization,and preparative HPLC techniques.The structures of the compounds were identified on the basis of spectral data including NMR,MS,and IR.Results Two sesquiterpene lactones,majucin(1)and anisatin(2),two steroids,β-sitosterol(3)and daucosterol(4),three carboxylic acids,2-ethyldecanoic acid(5),shikimic acid(6),and 3,4-dihydrobenzoic acid(7),and a flavonoid,quercetin(8),were successively isolated from the stem barks of I.difengpi.Conclusion Apart from compound 3,other seven compounds are reported in this plant for the first time.The results suggested that the current studies on I.difengpi is still far from being well known and therefore more studies need to be done for better understanding of this plant. | Yong-zhi He Eric Kibagendi Osoro Sivoko Imbenzi Palmer Li-ning Wang Naji Said Aboud | 2014 | Chinese Herbal Medicines2014，6，1： | 4 |
| 2 | Chemical Constituents in Extracts from Leaves of Lantana trifolia and Their In Vitro Anti-oxidative Activity显示文摘Objective To isolate, purify, and analyze the anti-oxidants from the leaves of Lantanatrifolia. Methods The anti-oxidative activities of the crude extracts from liquid-liquid extraction of L. trifolia leaves were assayed by 1,1-diphenyl-2-picrylhydrazyl(DPPH) method to assess their radical scavenging and reducing abilities. The total flavonoidsand phenol contents in the ethyl acetate fraction were determined by colorimetric and Folin–Ciocalteu methods, respectively. Chemical constituents were isolated from the ethyl acetate fraction and repeatedly purified using silica gel, Sephadex LH-20 column chromatography, and HPLC, respectively. The chemical structures isolated were identified by spectral analysis and chemical evidence. Results Ethyl acetate partition from liquid-liquid extraction exhibited the highest anti-oxidative activity with an IC50 value of 4.94 μg/mL, close to that of the standard(vitamin C, VC, 4.23 μg/mL). The extract was proved to contain total flavonoids and phenol contents with values of(39.0 ± 1.6) and(29.27 ± 1.46) mg/g, respectively. Six compounds were isolated and identified as kaempferol-3,7-dimethyl ether(1), verbascoside(2), apigenin(3), umuhengerin(4), ladanetin(5), and scutellarein-7-O-β-D-apiofuranoside(6).Conclusion The ethyl acetate extract from the leaves of L. trifolia possesses the potent anti-oxidative and free radical scavenging activities which are directly proportional to the concentration of phenolic contents. The anti-oxidative activity of the extract from the leaves of L. trifolia is due to its proton donating ability that converts free radicals to more stable products and terminates chain reactions. Compound 1 is isolated from the plants of Lantana Linn. for the first time. The mechanisms may be related to the therapeutic benefits of the certain traditional claims of wild L. trifolia. | Palmer Sivoko Imbenzi Yong-zhi He Zhi-xue Yan Eric Kibagendi Osoro Peter K Cheplogoi | 2014 | Chinese Herbal Medicines2014，6，3： | 4 |
| 3 | Effect of temperature on alkane extraction from faeces and herbage显示文摘 | Osoro K | 1999 | J Agri Sci Cambridge1999，132，： | 1 |
| 4 | Anthelmintic and nutritional effects of heather supplementation on Cashmere goats grazing perennial ryegrass-white clover pasture显示文摘 | OSORO K MATEOS S A FRUTOS P | 2007 | Journal of Animal Science2007，85，： | 1 |
| 5 | Impact of vericiguat on heart failure with reduced ejection fraction:a review显示文摘Introduction:Heart failure is a major public health issue with a prevalence of about 26 million people worldwide.Reduced nitric oxide availability,lower soluble guanylate cyclase(sGC)activity,and decreased cyclic guanosine monophosphate(cGMP)production are the causes of HF's development.Vericiguat prescribed under the brand name Verquvo was approved by U.S.Food and Drug Administration(FDA)in January 2021.It is a novel agent and the first sGC stimulator which helps to treat patients suffering from heart failure with reduced ejection fraction(HFrEF).Objective:The mechanism of action(cGMP pathway)of vericiguat,its clinical trials,its use in the treatment of heart failure,and its possible future aspects in therapeutic recommendations are all covered in this review.It will also raise awareness amongst healthcare professionals about the pharmacokinetic and pharmacodynamic parameters,dosing,administration,and drug-related problems of this new drug.Methods:Various databases for drug review were used in this review like PubMed,Medline,Google scholar,Drug bank,U.s.FDA,Medscape,and European society of cardiology guidelines.A total of 58 articles were screened out of which 39 articles were included in this review.Results:This review discusses vericiguat's mechanism of action(cGMP pathway),clinical studies,application in the treatment of heart failure,and potential future considerations in therapeutic recommendations.It will also educate healthcare professionals about the new drug's pharmacokinetics and pharmacodynamics,dose,administration,and drug-related problems.Conclusion:After hospitalization for HFrEF,the 5-year survival rate is just 25%,and disease morbidity and death are stil significant.As adjunctive therapy for individuals with heart failure and a low ejection fraction,vericiguat has a moderate level of effectiveness.Vericiguat's efficacy as an adjunct therapy to different drugs used to cure HF has to be further investigated.Vericiguat's safety and dosage in patients who have severe renal or hepatic illness need to be studied further. | Manisha Vohra Mohammad Amir Ian Osoro Amit Sharma Ranjeet Kumar | 2023 | Global Health Journal2023，7，3： | 1 |
| 6 | Effect of temperature on alkane extraction from faeces and herbage显示文摘 | Olivan M Osoro K | 1999 | Journal of Agricultural Science Cambridge1999，132，： | 1 |
| 7 | Anthelmintic and nutritional effects of heather supplementation on Cashmere goats grazing perennial ryegrass-white clover pastures显示文摘 | Osoro K Mateos-Sanz A Frutos P | 2007 | Journal of Animal Science2007，85，3： | 1 |
| 8 | Gas–liquid chromatographic method for analysing complex mixtures of fatty acids including conjugated linoleic acids ( cis 9 trans 11 and trans 10 cis 12 isomers) and long-chain (n-3 or n-6) polyunsaturated fatty acids显示文摘 | N. Aldai K. Osoro L.J.R. Barrón A.I. Nájera | 2006 | Journal of Chromatography A2006，，1： | 1 |
| 9 | Gas-liquid chromato- graphic method for analysing complex mixtures of fatty acids including conjugated linoleic acids ( cis9 trans l 1 and trans l O cis l 2 isomers) and long-chain (n-3 or n-6) polyunsaturated fatty acids application to the intramuscular fat of beef meat显示文摘 | ALDAI N OSORO K BARRON L J R | 2006 | Journal of Chromatography A2006，1110，12： | 1 |
| 10 | Effect of temperature on alkane extraction from faeces and herbage 显示文摘 | Olivan M Osoro K | 1999 | Journal Agricultural Science Cambridge1999，132，： | 1 |
| 11 | Estimation of feed intake by cattle using controlledrelease capsules containing n-alkanes or chromium sesquioxide显示文摘 | Ferreira LMM Olivan M Rodrigues MAM Osoro K Dove H Dias-DaSilva A | | 0，，： | 1 |
| 12 | Effect of temperature on alkane extraction from faeces and herbage显示文摘 | OLIVAN M OSORO K | 1999 | J Agtic Sci Camb1999，132，： | 1 |
| 13 | The effect of Cal luna vulgaris cover on the performance and intake of ewes grazing hill pastures in northern Spain显示文摘 | Osoro K Olivan M Celaya R | 2000 | Grass and Forage Science2000，55，： | 1 |
| 14 | Effect of temperature on alkane extraction from faeces and herbage显示文摘 | Olivan M Osoro K | | 0，，： | 1 |
| 15 | Effect of temperature on alkane ex traction from faeces and herbage显示文摘 | Olivan M Osoro K | 1999 | Journal of Agrieul rural Science1999，132，： | 1 |
| 16 | Effect of temperature on alkane extraction from faeces and herbage 显示文摘 | Olivan M Osoro K | 1999 | Journal Agricultural Science Cambridge1999，132，： | 1 |
| 17 | The effect of body condition, live weight, breed, age, calf performance, and calving date on reproductive performance of spring - calving beef cows显示文摘 | Osoro K Wright I A | 1992 | Journal of Animal Science1992，70，6： | 1 |
| 18 | Public health progression and related challenges显示文摘Public health has experienced a significant improvement over the last decades.Two factors are responsible for this:increased scientific knowledge through research and acceptance of health as a public responsibility.Conducting more health surveys and publishing the results has been proven to substantially improve public health particularly in developing nations.Public health research remains of utmost importance to society.1-3 Both non-communicable and communicable diseases are on the rise and they are of great concern regardless of age,sex or any other individualistic categorization. | Amit Sharma Ian Osoro | 2023 | Global Health Journal2023，7，1： | 0 |
| 19 | ABCA1敲低对小鼠巨噬细胞中Pam3CSK4引起的炎症反应的双向调节作用显示文摘目的检测ABCA1敲低对巨噬细胞中Pam3CSK4引起的炎症应答的影响。方法构建小鼠单核巨噬细胞RAW264.7的ABCA1敲低的稳定细胞系,以TLR2配体Pam3CSK4刺激该细胞系建立炎症反应细胞模型,在该细胞模型上检测相关促炎和抗炎细胞因子转录水平的表达变化。结果 ABCA1敲低的RAW264.7稳定细胞株在Pam3CSK4刺激后,IL-1β,TNF-α和IL-6表达发生显著上调(P<0.01),而转录抑制因子cAMP依赖性转录因子3(ATF3)也发生显著上调(P<0.01);与此同时,ATF蛋白家族中其它因子ATF1,ATF2,ATF4和ATF5转录水平没有发生显著变化。结论在巨噬细胞RAW264.7中,ABCA1敲低显著上调Pam3CSK4引起的促炎因子IL-1β,TNF-α和IL-6的表达的同时,也显著上调了具有抗炎效应的ATF3的表达,其对炎症反应的影响可能并非是单向的促炎作用,而是发生双向的调节,而ABCA1参与上调ATF3表达的机制可能也与其ATF蛋白家族其他成员的上游调节机制不同。 | 李玥 蓝茜 武丽涛 杜小娟 Ezra Kombo Osoro 李冬民 吕社民 | 2017 | 南方医科大学学报2017，37，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员