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| 1 | Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer显示文摘AIM: To investigate the prognostic role of KRAS and BRAF mutations after adjustment for microsatellite instability(MSI) status in Japanese colorectal cancer(CRC) population.METHODS: We assessed KRAS and BRAF mutations and MSI status in 813 Japanese patients with curatively resected, stage Ⅰ-Ⅲ CRC and examined associations of these mutations with disease-free survival(DFS) and overall survival(OS) using uni- and multivariate Cox proportional hazards models.RESULTS: KRAS and BRAF mutations were detected in 312(38%) of 812 and 40(5%) of 811 tumors, respectively. KRAS mutations occurred more frequently in females than in males(P = 0.02), while the presence of BRAF mutations was significantly associated with the female gender(P = 0.006), proximal tumor location(P < 0.001), mucinous or poorly differentiated histology(P < 0.001), and MSI-high tumors(P < 0.001). After adjusting for relevant variables, including MSI status, KRAS mutations were associated with poorer DFS(HR = 1.35; 95%CI: 1.03-1.75) and OS(HR = 1.46; 95%CI: 1.09-1.97). BRAF mutations were poor prognostic factors for DFS(HR = 2.20; 95%CI: 1.19-4.06) and OS(HR = 2.30; 95%CI: 1.15-4.71). Neither the BRAF by MSI interaction test nor the KRAS by MSI interaction test yielded statistically significant results for DFS and OS.CONCLUSION: KRAS and BRAF mutations are associated with inferior survival, independent of MSI status, inJapanese patients with curatively resected CRC. | Shigenori Kadowaki Miho Kakuta Shuhei Takahashi Akemi Takahashi Yoshiko Arai Yoji Nishimura Toshimasa Yatsuoka Akira Ooki Kensei Yamaguchi Keitaro Matsuo Kei Muro Kiwamu Akagi | 2015 | World Journal of Gastroenterology2015，21，4： | 14 |
| 2 | Results of immunotherapy for patients with unexplained primary recurrent abortions-prospective non-randomized cohort study 显示文摘 | Nonaka T Takakuwa K Ooki I | 2007 | Am J Reprod Immunol2007，58，6： | 1 |
| 3 | Results of Immunotherapy for Patients with Unexplained Primary Recurrent Abortions-Prospective Non-Randomized Cohort Study显示文摘 | Nonaka T Takakuwa K Ooki I | 2007 | Am J Reprod Immunol2007，58，6： | 1 |
| 4 | Complex chromosomal rear- rangements in couples affected by recurrent spontaneous abortion 显示文摘 | Nonaka T Ooki I Enomoto T | 2015 | Int J Gynaecol Obstet2015，128，1： | 1 |
| 5 | Appli:ation of Probabilistie Neural Network to Design Breakwater Armor Bloc:ks显示文摘 | Kim D Ookie Hyawn Kim Dong Chang Seongkyu | 2008 | Ocean Engineering2008，，35： | 1 |
| 6 | Lymph node metastasis density and goowth pattern as independent prognostic factor in advanced esophagear squamous cell carcinoma显示文摘 | Ooki A Yamashita K Kobayashi N | 2007 | World J Surg2007，31，11： | 1 |
| 7 | Results of Immunotherapy for Patients with Unexplained Primary Recurrent Abortions Prospective Non-Randomized Cohort Study显示文摘 | Nonaka T Takakuwa K Ooki I | 2007 | Am J Reprod Immunol2007，58，6： | 1 |
| 8 | Structure of Unidirectionally Solidified Hypoeutectic White Cast Iron显示文摘 | K OOKI and K MATUDA | 1971 | IMONO1971，43，6： | 1 |
| 9 | Development of a Silicone Membrane Tube Equilibrator for Measuring Par- tial Pressures of Volatile Organic Compounds in Natural Water 显示文摘 | ATSUSHI OOKI YOKO YOKOUCHI | 2008 | Environ Sci Technol2008，42，： | 1 |
| 10 | Recent developments in gastric endoscopic submucosal dissection: towards the era of endoscopic resection of layers deeper than the submucosa 显示文摘 | Abe N Takeuchi H Ooki A | 2013 | Dig Endnsc2013，25，： | 1 |
| 11 | Clinical significance of total gastrectomy for proximal gastric cancer显示文摘 | Ooki A Yamashita K Kikuchi S | 2008 | Anticancer Res2008，28，5： | 1 |
| 12 | Phosphatase of regenerating liver-3 as a convergent therapeutic target for lymph node metastasis in esophageal squamous cell carcinoma显示文摘 | Ooki A Yamashita K Kikuchi S | 2009 | Int J Cancer2009，12，： | 1 |
| 13 | Phosphatase of regeneratingliver-3 as a convergent therapeutic target for lymph node metastasis inesophageal squamous cell carcinoma显示文摘 | Ooki A Yamashita K Kikuchi S | 2010 | Int J Cancer2010，127，3： | 1 |
| 14 | Vector diffraction theory for magnetooptical disc systems显示文摘 | Ooki H | 1991 | Optik1991，39，1： | 1 |
| 15 | Recent developments in gastric endoscopic submucosal dissection: towards the era of endoscopic resection of layers deeper than the submu- cosa 显示文摘 | Abe N Takeuchi H Ooki A | 2013 | Digestive Endoscopy2013，25，1： | 1 |
| 16 | Complex chromosomal rearrangements in couples affected by recurrent spontaneous abortiorn显示文摘 | Nonaka T Ooki I Enomoto T | 2015 | Int J Gynecol Obstet2015，128，1： | 1 |
| 17 | Effects of Post-annealing in Ozone Environment on Opto-electrical Properties of Sn-doped In2O3 Yhin Films显示文摘 | Mori N Ooki S Masubuchi N | 2002 | Thin Solid Films2002，411，： | 1 |
| 18 | Potential utility of HOPhomeobox gene promoter methylation as a marker of tumor aggr-essiveness in gastric cancer显示文摘 | Ooki A Yamashita K Kikuchi S | 2010 | Oncogene2010，29，22： | 1 |
| 19 | Adjuvant effect of multi-CpG motifs on an HIV-1 DNA vaccine显示文摘 | KOJIMA Y XIN K Q OOKI T | 2002 | Vaccine2002，20，2324： | 1 |
| 20 | A prospective observational study to examine the relationship between quality of life and adverse events of first-line chemotherapy plus cetuximab in patients with KRAS wild-type unresectable metastatic colorectal cancer: QUACK Trial显示文摘 | Ooki A Ando M Sakamoto J | 2014 | Jpn J Clin Oncol2014，44，4： | 1 |
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