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| 1 | Modulation of mitochondrial bioenergetics as a therapeutic strategy in Alzheimer's disease显示文摘Alzheimer's disease(AD) is an increasingly pressing worldwide public-health, social, political and economic concern. Despite significant investment in multiple traditional therapeutic strategies that have achieved success in preclinical models addressing the pathological hallmarks of the disease, these efforts have not translated into any effective disease-modifying therapies. This could be because interventions are being tested too late in the disease process. While existing therapies provide symptomatic and clinical benefit, they do not fully address the molecular abnormalities that occur in AD neurons. The pathophysiology of AD is complex; mitochondrial bioenergetic deficits and brain hypometabolism coupled with increased mitochondrial oxidative stress are antecedent and potentially play a causal role in the disease pathogenesis. Dysfunctional mitochondria accumulate from the combination of impaired mitophagy, which can also induce injurious inflammatory responses, and inadequate neuronal mitochondrial biogenesis. Altering the metabolic capacity of the brain by modulating/potentiating its mitochondrial bioenergetics may be a strategy for disease prevention and treatment. We present insights into the mechanisms of mitochondrial dysfunction in AD brain as well as an overview of emerging treatments with the potential to prevent, delay or reverse the neurodegenerative process by targeting mitochondria. | Isaac G. Onyango | 2018 | Neural Regeneration Research2018，13，1： | 11 |
| 2 | High speed sorting of potatoes using computer vision显示文摘 | Onyango C M Street M J | 1988 | Transactions of the ASAE1988，88，： | 1 |
| 3 | Removal of nickel from wastewater using an agricultural adsorbent显示文摘 | Moodley Krishnie Singh Ruella Musapatika Evans T Onyango Maurice S Ochieng Aoyi | 2011 | Water SA2011，，1： | 1 |
| 4 | Adsorption equilibrium modeling and solution chemistry dependence of fluoride removal from water by trivalent-cation-exchanged zeolite F-9 显示文摘 | Onyango M S Kojima Y Aoyi O | 2004 | J Colloid Interface Sci2004，279，2： | 1 |
| 5 | Preparation of activated carbon from petroleum coke by KOH chemi-cal activation for adsorption heat pump显示文摘 | Kawano T Kubota M Onyango M S | | 0，，8： | 1 |
| 6 | Visfatin regulates insulin secretion,insulin receptor signalling and mRNA expression of diabetes-related genes in mouse pancreatic p-cells显示文摘 | Brownj EP Onyango DJ Ramanjaneya M | 2010 | J Mol Endocrinol2010，44，3： | 1 |
| 7 | SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochon- dria显示文摘 | Onyango P Celic I Mccaffery JM | 2002 | Proc NatlAcad Sci USA2002，99，13： | 1 |
| 8 | Segmentation of row crop plants from weeds using color and morphology显示文摘 | Onyango C M Marchant J A | 2003 | Computers and Electronics in Agriculture2003，，39： | 1 |
| 9 | Adsorption equilibrium modeling and solution chemistry depend- ence of fluoride removal from waterhy trivalent-cat- ion-exchanged zeolite F-9 显示文摘 | Onyango M S Kojima Y Aoyi O | 2004 | J Colloid Interface Sci2004，279，： | 1 |
| 10 | The yeast productionsystem in which Escherichia coli phytase is expressed may affectgrowth performance,bone ash,and nutrient use in broiler chicks显示文摘 | Onyango E M Bedford M R Adeola 0 | 2004 | Poult Sci2004，83，： | 1 |
| 11 | A nucleolar protein, H19 oppo- site tumor suppressor ( HOTS), is a tumor growth inhibitor enco- ded by a human imprinted H19 antisense transcript显示文摘 | ONYANGO P FEINBERG A P | 2011 | Proc Natl Acad Sci U S A2011，108，16： | 1 |
| 12 | Phytic acid increases muein and endogenous amino acid losses from the gastrointestinal tract of chickens显示文摘 | Onyango E M Asem E K Adeola O | 2009 | Br J Nutr2009，101，6： | 1 |
| 13 | Mixing in a tank stirred by a rushton turbine at a low clearance显示文摘 | Onyango M S Kumar A | 2008 | Chemical Engineering and Processing2008，47，： | 1 |
| 14 | High Speed Sorting of Potatoes Using Computer Vision显示文摘 | Marchant J A Onyango C M Street MJ | 1988 | ASAE1988，88，： | 1 |
| 15 | Visfatin regulates insulin secretion,insulin receptor signalling and mRNA expression ofdiabetes-related genes in mouse pancreatic beta-cells 显示文摘 | BROWN J E ONYANGO D J RAMANJANEYAM | 2011 | J Mol Endocrinol2011，44，3： | 1 |
| 16 | The potential of solar chimney for application in rural areas of developing countries 显示文摘 | Onyango F N Ochieng R M | 2006 | Fuel2006，85，17： | 1 |
| 17 | Analysis of cost effective pavement treatment and budget optimization for arterial roads in the city of Chattanooga显示文摘 | Mbakisya ONYANGO Saliha Ammour MERABTI Joseph OWINO Ignatius FOMUNUNG Weidong WU | 2018 | Frontiers of Structural and Civil Engineering2018，12，3： | 1 |
| 18 | Regulation of neuron mitochondrial biogenesis and relevance to brain health 显示文摘 | Onyango IG Lu J Rodova M | 2012 | Biochim Biophys Acta2012，1802，1： | 1 |
| 19 | Development of aWHO growth reference for school-aged children and adolescents显示文摘 | de Onis M Onyango AW Borghi E | 2007 | Bulletin of the World Health Organization2007，85，9： | 1 |
| 20 | Influence of incubation temperature and time on resistant starch type Ⅲ formation from autoclaved and acid-hydrolysed cassava starch显示文摘 | Onyango C Bley T Jacob A | 2006 | Carbohydrate Polymers2006，66，4： | 1 |
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