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168篇 您的检索式:作者名="Offringa"
    题名 作者 年代 出处 被引量
1新型热塑性复合材料设计理念及其自动化制造显示文摘热塑性复合材料的自身特性使其成为重量轻、低成本宇航结构件的理想材料,该类复合材料以韧性高、重复加工性好和防火性能强而著称。针对大型主结构件(如蒙皮加筋整体壁板)正取得了多个阶段性进展。新材料、创新的设计理念和航空技术是主要的创新要素。Arnt Offringa 李香波 2010航空制造技术2010,53,24:7
2Phosphorylation‐dependent Traffcking of Plasma Membrane Proteins in Animal and Plant Cells显示文摘In both unicellular and multicellular organisms,transmembrane(TM)proteins are sorted to and retained at specifc membrane domains by endomembrane traffcking mechanisms that recognize sorting signals in the these proteins.The traffcking and distribution of plasma membrane(PM)‐localized TM proteins(PM proteins),especially of those PM proteins that show an asymmetric distribution over the PM,has received much attention,as their proper PM localization is crucial for elementary signaling and transport processes,and defects in their localization often lead to severe disease symptoms or developmental defects.The subcellular localization of PM proteins is dynamically regulated by post‐translational modifcations,such as phosphorylation and ubiquitination.These modifcaitons mostly occur on sorting signals that are located in the larger cytosolic domains of the cargo proteins.Here we review the effects of phosphorylation of PM proteins on their traffcking,and present the key examples from the animal feld that have been subject to studies for already several decades,such as that of aquaporin 2 and the epidermal growth factor receptor.Our knowledge on cargo traffcking in plants is largely based on studies of the family of PIN FORMED(PIN)carriers that mediate the effux of the plant hormone auxin.We will review what is known on the subcellular distribution and traffcking of PIN proteins,with a focus on how this is modulated by phosphorylation,and identify and discuss analogies and differences in traffcking with the well‐studied animal examples.Remko Offringa Fang Huang 2013Journal of Integrative Plant Biology2013,55,9:4
3An INDEHISCENT-Controlled Auxin Response Specifies the Separation Layer in Early Arabidopsis Fruit显示文摘种子疏开是在植物种的生命周期的一重要时刻。在 Arabidopsis thaliana,它依赖于抄写因素果皮不裂(IND ) 调停了在裂开地区的分离层的说明在在阀门(心皮墙) 和发展中的水果的中央洋梅之间的边缘发现了。IND 由在水果开发的迟了的阶段导致本地植物生长素最小指定分离层,这被建议。这里,我们证明 ind 异种和野类型的水果之间的词法差别已经在水果开发的早阶段产生,与在阀门边缘的强壮的 IND 表示与一致。我们证明减少 IND 的 PIN-FORMED3 (PIN3 ) 植物生长素流出搬运人丰富在早水果开发期间在阀门边缘导致增加的植物生长素回答,并且形成裂开地区的伴随物房间部门缺乏 ind 变异的水果。而且, AGC kinases PINOID (PID ) 的 IND 倡导者驱动的宫外的表示和 WAG2 由通过增加的 PIN3 丰富在水果开发的阶段 14-16 从阀门边缘驱逐植物生长素导致了 indehiscence。我们的结果证明除它在 Arabidopsis 水果开发的迟了的阶段的角色以外, IND 在早阶段工作便于形成裂开地区的被触发植物生长素的房间部门。Kasper van Gelderen Martin van Rongen An'an Liu Anne Otten Remko Offringa 2016Molecular Plant2016,9,6:3
4Anthracycline-induced clinical heart failure in a cohort of 607 children:Long-term follow-up study显示文摘Kremer LC van Dalen EC Offringa M 2001J Clin Oncol2001,19,1:1
5Excess mortality after human albumin administrationin critically ill patients 显示文摘Offringa M 1998BMJ1998,317,:1
6Regulation of auxin transport polarity by AGC kinases显示文摘HE(E) L(E) NE S ROBERT REMKO OFFRINGA 2008Current Opinion in Plant Biology2008,,11:1
7Efflux-dependent auxin gradients establish the apical-basal axis of Arabidopsis 显示文摘Friml J Vieten A Sauer M Weijers D Schwarz H Hamann T Offringa R Jurgens G 2003Nature2003,426,:1
8Cancer immunotherapy is more than a numbers game 显示文摘Offringa R 2006Science2006,314,5796:1
9Risk factors for seizure fecurrence in childre with febrile seizures: A pooled analysis of divedual data from five studies显示文摘Offringa M Bossuyt PM Lubsen J 1994J Pe- diatr1994,124,4:1
10Elective high - frequency oscillatory versus conventional ventilation in preterm infants: a systematic review and meta - analysis of individual patients'data 显示文摘Cools F Askie LM Offringa M 2010Lancet2010,375,9731:1
11Frequency and risk factors of anthracycline-induced clinical heart failure in children: a systematic review显示文摘Kremer LCM van Dalen EC Offringa M 2002Ann Oncol2002,13,5:1
12Anthracycaline induced clinical heart failure-up study 显示文摘Kremer LC Vam-Dalen EC Offringa M 2001J Clin Oncol2001,19,1:1
13Ectopic expression of BABYBOOM triggers a conversion from vegetative to embryonic growth 显示文摘Boutilier K Offringa R Sharma V K 2002Plant Ce112002,14,:1
14The effective- ness of three multi-component binding models in descri- bing the binary competitive equilibrium adsorption of two cytochrome b5 mutants 显示文摘GANO T OFFRINGA N WILLSON R C 2007J Chromatogr A2007,1144,2:1
15Systemic Hydrocortisone To Prevent Bronchopulmonary Dysplasia in preterm infants (the SToP-BPD study);a multicenter randomized placebo controlled trial 显示文摘Onland W Offringa M Cools F 2011BMC Pediatr2011,11,:1
16Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants 显示文摘Cools F Henderson-Smart DJ Offringa M 2009Co- chrane Database Syst Rev2009,,00:1
17Anthracycline-induced clinical heart failure in a cohort of 607 children: tong-term follow-up study显示文摘Kremer LC van Dalen EC Offringa M 2001J Clin Oncol2001,19,1:1
18Vitamin E, lipid fractions, and fatty acid composition of colostrum, transitional milk,and mature milk:an international comparative study 显示文摘BOERSMA E R OFFRINGA P J MUSKIET F A J 1991Am J Clin Nutr1991,53,:1
19Tumor eradi- cation by wild-type p53-specific cytotoxic T lymphocytes 显示文摘Vierboom MP Nijman HW Offringa R 1997J Exp Med1997,186,5:1
20Troponin T in the first 24 hours after the administration of chemotherapy and the detection of myocardial damage in children显示文摘Kremer LC Bastiaansen BA Offringa M 2002Eur J Cancer2002,38,5:1
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