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| 1 | The innate immune response to allotransplants: mechanisms and therapeutic potentials显示文摘Surgical trauma and ischemia reperfusion injury(IRI)are unavoidable aspects of any solid organ transplant procedure.They trigger a multifactorial antigen-independent inflammatory process that profoundly affects both the early and long-term outcomes of the transplanted organ.The injury associated with donor organ procurement,storage,and engraftment triggers innate immune activation that inevitably results in cell death,which may occur in many different forms.Dying cells in donor grafts release damage-associated molecular patterns(DAMPs),which alert recipient innate cells,including macrophages and dendritic cells(DCs),through the activation of the complement cascade and toll-like receptors(TLRs).The long-term effect of inflammation on innate immune cells is associated with changes in cellular metabolism that skew the cells towards aerobic glycolysis,resulting in innate immune cell activation and inflammatory cytokine production.The different roles of proinflammatory cytokines in innate immune activation have been described,and these cytokines also stimulate optimal T-cell expansion during allograft rejection.Therefore,early innate immune events after organ transplantation determine the fate of the adaptive immune response.In this review,we summarize the contributions of innate immunity to allograft rejection and discuss recent studies and emerging concepts in the targeted delivery of therapeutics to modulate the innate immune system to enhance allograft survival. | Jordi Ochando Farideh Ordikhani Peter Boros Stefan Jordan | 2019 | Cellular & Molecular Immunology2019，16，4： | 5 |
| 2 | Uremic pruriyus: an unresolved problem in hemodialysis patients显示文摘 | Goiocechea M de Sequera P Ochando A | 1999 | Nephron1999，82，1： | 1 |
| 3 | Migration of dendritic cell subsets and their precursors显示文摘 | Randolph G J Ochando J Partida-Sanchez S | 2008 | Annu Rev Immunol2008，26，： | 1 |
| 4 | Uremic pruriyus:an unresolved problem in hemodialysis patients显示文摘 | Goicoechea M de Sequera P Ochando A | 1999 | Nephron1999，82，1： | 1 |
| 5 | Molecular identification(RAPD)of the eight species of the genus Barbus(Cyprinidae)in the Iberian Peninsula显示文摘 | CALLEJAS C OCHANDO M D | 2001 | J Fish Bio2001，59，： | 1 |
| 6 | Sphingosine 1-phosphate receptor modulators:a new class of immunosuppressants显示文摘 | Yopp AC Ledgerwood LG Ochando JC | 2006 | Clin Transplant2006，20，6： | 1 |
| 7 | Alloantigen-presenting plas- macytoid dendritic cells mediate tolerance to vascularized grafts 显示文摘 | Ochando JC Homma C Yang Y | 2006 | Nat Immuno12006，7，6： | 1 |
| 8 | Uremic pruritus:an unresolved problem in hemodialysis patients显示文摘 | Goicoechea M de Sequera P Ochando A | 1999 | Nephron1999，82，1： | 1 |
| 9 | IL-6 plays a unique role in initiating c-Maf expression during early stage of CD4 T cell activation显示文摘 | Yang Y Ochando J Yopp A | 2005 | J Immunol2005，174，： | 1 |
| 10 | Alloantigen-presenlMg plasmacytoid dendritic cells mediate tolerance to vascularized grafts 显示文摘 | Ochando JC Homma C Yang Y | 2006 | Nat Immunol2006，7，6： | 1 |
| 11 | Laparoscopic colectomy for transverse colon carcinoma: a surgical challenge but oncologically feasible显示文摘 | J. M. Fernández‐Cebrián P. Gil Yonte M. Jimenez‐Toscano L. Vega F. Ochando | 2013 | Colorectal Dis2013，，2： | 1 |
| 12 | Uremic pruritus:an unresolved problem in hemodialysis patients显示文摘 | Goicoechea M de Sequera P Ochando A | 1999 | Nephron1999，82，1： | 1 |
| 13 | Identification of a distant T-bet enhancer responsive to IL-12/Stat4 and IFNgamma/Statl signals 显示文摘 | Yang Y Ochando JC Bromberg JS | 2007 | Blood2007，110，7： | 1 |
| 14 | Nutritional management of the patient after surgery of the biliary tract and pancreas显示文摘 | Loinaz Segurola C Ochando Cerdán F | 2008 | Nutr Hosp2008，23，2： | 1 |
| 15 | Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts 显示文摘 | Ochando JC Homma C Yang Y | 2006 | Nat Immunol2006，7，6： | 1 |
| 16 | Identification of a distant T-bet enhancer responsive to IL-12/STAT4 and IFNgamma/STAT1signals显示文摘 | YANG Y OCHANDO J C BROMBERG J S | 2007 | Blood2007，110，7： | 1 |
| 17 | Uremic pruritus:an unresolved problem in hemodialysis patients显示文摘 | Goicoechea M Pde sequera Ochando A | 1999 | Nephon1999，82，1： | 1 |
| 18 | Migration of Dendritic Cell Subsets and their Precursors显示文摘 | Gwendalyn J. Randolph Jordi Ochando Santiago Partida-Sánchez | 2008 | Annual Review of Immunology2008，，： | 1 |
| 19 | Migration of dendritic cell subsets and their precursors 显示文摘 | Randolph GJ Ochando J Partida-Sanchez S | 2008 | Annu Rev Inununol2008，26，： | 1 |
| 20 | Uremic pruritus:an unresolved problem in hemodialysis patients显示文摘 | Goicoechea M Pde sequera Ochando A | 1999 | Nephon1999，82，1： | 1 |
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