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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Costs of Equity and Earnings Attributes显示文摘 | Lafond R Olsson P M Schipper K | 2004 | The Accounting Review2004，79，4： | 1 |
| 3 | Intestinal colonization potential of Turbot ( Scophthalmus maximus ) and Dab (Limanda limanda )-associated bacteria with inhibitory effects against Vibrio anguillarum 显示文摘 | OLSSON J C WESTERDAHL A CONWAY P | 1992 | Appl Environ Microbiol1992，58，2： | 1 |
| 4 | Infrared properties of β'-Sialon as a function of comsition显示文摘 | Andersson S K Staaf O Olsson P O | 1998 | Optical Materials1998，10，： | 1 |
| 5 | Comparing the accuracy and explainability of dividend, free cash flow, and abnormal earnings equity value estimates 显示文摘 | Francis J Olsson P Oswald D R | 2000 | Journal of Accounting Research2000，，38： | 1 |
| 6 | Improved diagnostic classificationof alcohol abusers by combining carbohydrate-deficient transferrin and gamma-glutamyltransferase显示文摘 | Sillanaukee P Olsson U | 2001 | Clin Chem2001，47，4： | 1 |
| 7 | Structural characterization of a lipase-catalyzed copolymerization of ε-caprolactone and D, L-Lactide 显示文摘 | Wahlberg J Persson P V Olsson T | 2003 | Biomacromolecules2003，4，4： | 1 |
| 8 | Clinical severity of Mycoplasma pneumoniae(MP) infection is associated with bacterial load in oropharyngeal secretions but not with MP genotype显示文摘 | Nilsson A C Bjrkman P welinder - Olsson C | 2010 | BMC Infect Dis2010，10，： | 1 |
| 9 | 99mTc-labeled superpara- magnetic iron oxide nanoparticles for muhimodality SPECT/MRI of sentinel lymph nodes显示文摘 | Madru R Kjellman P Olsson F | 2012 | J Nucl Med2012，53，3： | 1 |
| 10 | Multi-locus phylogeny of the family Acrocephalidae (Aves:Passeriformes)-The traditional taxonomy overthrown显示文摘 | Fregin S Haase M Olsson U Alstr(o)m P | | 0，，： | 1 |
| 11 | 显示文摘 | Nyman P Maki R Olsson R | 2006 | Wear2006，261，： | 1 |
| 12 | Production of the artemisinin precursor amorpha -4, 11 -diene by engineered Saccharomyces cerevisiae 显示文摘 | Lindahl AL Olsson ME Mercke P | 2006 | Biotechnology Letters2006，28，8： | 1 |
| 13 | Intestinal colonization potential of turbot (Scophthalmus maximus) and dab (Limanda limanda) - associated bacteria with inhibitory effects against Vibrio anguillarum显示文摘 | Olsson J C Westerdahl A Conway P | 1992 | Applied and Environmental Microbiology1992，58，2： | 1 |
| 14 | Cationic proteins of human granulocytes VI:Effects on the complement system and mediation of chemotactic activity显示文摘 | Venge P Olsson I | 1975 | J Immunol1975，115，： | 1 |
| 15 | New insights into family relationships within the avian superfamily Sylvioidea (Passeriformes) based on seven molecular markers显示文摘 | Fregin S Haase M Olsson U AlstrOm P | | 0，，： | 1 |
| 16 | Self-phase modulation and spectral broadening of optical pulses in semiconductor laser amplifiers 显示文摘 | G P Agrawal N A Olsson | 1989 | IEEE Journal of Quantum Electronits1989，25，11： | 1 |
| 17 | Fault diagnosis in industry using sensor readings and case-based reasoning显示文摘 | OLSSON E FUNK P XIONG N | 2004 | Journal of Intelligent and Fuzzy Systems2004，15，1： | 1 |
| 18 | Self-phase modulation and spectral broadening of optical pulses in semiconductor optical amplifiers显示文摘 | AGRAWAL G P OLSSON N A | 1989 | IEEE J Quantum Electron1989，25，： | 1 |
| 19 | T-cellmediatedcytotoxicity toward platelets in chronicid-iopathic thrombocytopenic purpura 显示文摘 | OLSSON B ANDERSSON P OJERNAS M | 2003 | Nat Med2003，9，： | 1 |
| 20 | Costs of Eq- uity and Earnings Attributes显示文摘 | Francis J R LaFond P Olsson K Schipper | 2004 | The Accounting Review2004，，79： | 1 |
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