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| 1 | Preventative effects of a probiotic, Lactobacillus salivarius ssp. salivarius, in the TNBS model of rat colitis显示文摘AIM: To investigate the intestinal anti-inflammatory effect and mechanism of a probiotic Lactobacillus sakuvarius ssp.salivariusCECT5713 in the TNBS model of rat colitis.METHODS: Female Wistar rats (180-200 g) were used in this study. A group of rats were administered orally the probiotic L. salivarius ssp. salivarius (5×108 CFU suspended in 0.5 mL of skimmed milk) daily for 3 wk. Two additional groups were used for reference, a non-colitic and a control colitic without probiotic treatment, which received orally the vehicle used to administer the probiotic. Two weeks after starting the experiment, the rats were rendered colitic by intracolonic administration of 10 mg of TNBS dissolved in 0.25 mL of 500 mL/L ethanol. One week after colitis induction, all animals were killed and colonic damage was evaluated both histologically and biochemically. The biochemical studies performed in colonic homogenates include determination of myeloperoxidase (MPO) activity,glutathione (GSH) content, leukotriene B4 (LTB4) and tumor necrosis factor α (TNF-α) levels, as well as inducible nitric oxide synthase (iNOS) expression. In addition, the luminal contents obtained from colonic samples were used for microbiological studies, in order to determine Lactobacilli and Bifidobacteria counts.RESULTS: Treatment of colitic rats with L. salivarius ssp.salivarius resulted in amelioration of the inflammatory response in colitic rats, when compared with the corresponding control group without probiotic treatment. This antiinflammatory effect was evidenced macroscopically by a significant reduction in the extent of colonic necrosis and/or inflammation induced by the administration of TNBS/ethanol (2.3+0.4 cm vs3.4+0.3 cm in control group,P<0.01) and histologically by improvement of the colonic architecture associated with a reduction in the neutrophil infiltrate in comparison with non-treated colitic rats. The latter was confirmed biochemically by a significant reduction of colonic MPO activity (105.3+26.0 U/g vs180.6±21.9 U/g, P<0.05), a marker of neutrophil infiltration. The beneficial effect was associated with an increase of the colonic GSH content (1 252±42 nmol/g vs 1 087+51 nmol/g, P<0.05),which is depleted in colitic rats, as a consequence of the oxidative stress induced by the inflammatory process. In addition, the treatment of colitic rats with L. salivarius resulted in a significant reduction of colonic TNF-α levels (509.4±68.2 pg/g vs782.9±60.1 pglg, P<0.01) and in a lower colonic iNOS expression, when compared to TNBS control animals without probiotic administration. Finally,treated colitic rats showed higher counts of Lactobacilli species in colonic contents than control colitic rats, whereas no differences were observed in Bifidobacteria counts.CONCLUSION: Administration of the probiotic L. salivarius ssp. salivarius CECT5713 facilitates the recovery of the inflamed tissue in the TNBS model of rat colitis, an effect associated with amelioration of the production of some of the mediators involved in the inflammatory response in the intestine, such as cytokines, including TNF-α and NO. This beneficial effect could be ascribed to its effect on the altered immune response that occurs in this inflammatory condition. | Laura Peran Desiree Camuesco Monica Comalada Ana Nieto Angel Concha Maria Paz Diaz-Ropero Monica Olivares Jordi Xaus Antonio Zarzuelo Julio Galvez | 2005 | World Journal of Gastroenterology2005，11，33： | 17 |
| 2 | Intraoperative ERCP : 它在 laparoscopic 胆囊炎的时代有什么角色?显示文摘 In the treatment of patients with symptomatic cholelithiasis and choledocholithiasis (CBDS) detected during intraoperative cholangiography (IOC),or when the preoperative study of a patient at intermediate risk for CBDS cannot be completed due to the lack of imaging techniques required for confirmation,or if they are available and yield contradictory radiological and clinical results,patients can be treated using intraoperative endoscopic retrograde cholangiopancreatography (ERCP) during the laparoscopic treatment or postoperative ERCP if the IOC finds CBDS.The choice of treatment depends on the level of experience and availability of each option at each hospital.Intraoperative ERCP has the advantage of being a single-stage treatment and has a significant success rate,an easy learning curve,low morbidity involving a shorter hospital stay and lower costs than the two-stage treatments (postoperative and preoperative ERCP).Intraoperative ERCP is also a good salvage treatment when preoperative ERCP fails or when total laparoscopic management also fails. | Luis R Rábago Alejandro Ortega Inmaculada Chico David Collado Ana Olivares Jose Luis Castro Elvira Quintanilla | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，12： | 13 |
| 3 | Liaison between natural killer cells and dendritic cells in human gestation显示文摘成功的怀孕依靠允许胎儿在子宫成长并且发展的免疫学的改编,尽管有被母亲的有免疫力的房间认出。在在人的母亲 / 胎儿的接口以内在场的几种免疫能力的房间类型之中, DC 签名 + 树枝状的房间(DC ) 和 CD56 + 天赋杀手(NK ) 房间具有为早怀孕维护的主要重要性,不是仅仅产生母亲的免疫学的忍耐而且调整 stromal 房间区别。以前的报告证明 NK-DC 房间的存在在第一三个月人蜕膜结合,建议这些房间可以起在在子宫以内的本地有免疫力的反应的调整的一个作用。当有效免疫是必要的保护母亲免受有害病原体的伤害时,忍耐的某形式必须被激活对胎儿的抗原避免有免疫力的回答。这篇评论文章在人的蜕膜在怀孕和他们的连音有关 DC 和 NK 房间的功能讨论当前的证据。 | Ester Leno-Duran | 2014 | Cellular & Molecular Immunology2014，11，5： | 7 |
| 4 | Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant显示文摘AIM: To investigate if conversion to the mammalian target of rapamycin inhibitors(mTORi) improves renal function in diabetic and/or hypertensive liver transplant patients immunosuppressed with tacrolimus or cyclosporine.METHODS: The study included 86 liver graft recipients immunosuppressed with mTORi treatment after orthotopic liver transplantation(OLT), including all liver recipients with worsening renal function before conversion to mTORi(n = 55 patients) and recipients with normal renal function who converted to m TORi for other reasons(n = 31 patients). We identified patients with diabetes mellitus(n = 28), arterial hypertension(n = 27), proteinuria(n = 27) and all three factors(n = 8)(some patients have hypertension and diabetes and no proteinuria). The primary endpoint was evolution in renal function defined as the development in plasma creatinine as a function of diabetes mellitus(DM), hypertension(HT) or proteinuria. We required elevated serum creatinine for at least two weeks to define renal dysfunction.RESULTS: Only patients that converted because of renal failure with plasma creatinine levels > 1.5 mg/dL showed an improvement of renal function(2.14 to 1.77 mg/dL)(P = 0.02). Patients with DM showed no improvement of serum creatinine levels(1.31 mg/dL to 1.37 mg/dL) compared with non DM patients(1.31 mg/dL to 1.15 mg/dL)(P = 0.01), HT patients(1.48 mg/dL to 1.5 mg/dL) with non HT patients(1.21mg/d L to 1.08 mg/dL) and patients with proteinuria(1.44 mg/dL to 1.41 mg/dL) and no proteinuria(1.31 mg/dL to 1.11 mg/dL). CONCLUSION: In OLT recipients with diabetes or hypertensive nephropathy, conversion to m TORi does not improve renal function but stabilizes plasma levels of creatinine. Proteinuria is not a contraindication to conversion to m TORi; it also stabilizes renal function. Conversion to m TORi should only be avoided in patients with diabetes, hypertension and proteinuria. | José M álamo Claudia Olivares Lydia Barrera Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Jordi Muntané Francisco J Padillo Miguel A Gómez | 2015 | World Journal of Transplantation2015，5，1： | 6 |
| 5 | Need for infliximab dose intensification in Crohn's disease and ulcerative colitis显示文摘AIM: To compare the need for infliximab dose intensification in two cohorts of patients with Crohn's disease(CD) or ulcerative colitis(UC).METHODS: Single centre, uncontrolled, observational study. Consecutive patients with CD and UC who responded to infliximab induction doses were included. Data collected in a prospectively maintained database were retrospectively analysed. Differences in the rates of dose intensification per patient-month and the intensification-free survival time were compared. We also evaluated the interval between the first infliximab induction dose and the first infliximab escalated dose. The weight-adjusted infliximab administration costs were also calculated.RESULTS: Fifty nine patients with CD and 38 patients with UC were enrolled. The rate of intensification per patient-month was 3.9% for UC and 1.4% for CD(P = 0.005). The median time from baseline to intensification was significantly shorter in UC compared to CD [6.6 mo(IQR: 4.2-9.5 mo) vs 10.7 mo(IQR: 8.9-11.7 mo), P = 0.005]. In the survival analysis, the cumulative probability of avoiding infliximab dose intensification was significantly higher in CD(P = 0.002). In the multivariate analysis, disease(UC vs CD) was the only factor significantly associated with dose intensification. The infiximab administration costs during the first year were significantly higher for UC compared to CD(mean ± SD 234.9 ± 53.3 Euros/kg vs 212.3 ± 15.1 Euros/kg, P = 0.03).CONCLUSION: The rate of infliximab dose intensification per patient-month is significantly higher in UC patients. The infliximab administration costs are also significantly higher in patients with UC. | Carlos Taxonera David Olivares Juan L Mendoza Manuel Díaz-Rubio Enrique Rey | 2014 | World Journal of Gastroenterology2014，20，27： | 2 |
| 6 | 生物刺激素对提高甘蔗产量的影响显示文摘本文连续3年研究了不同施用方式施用重氮营养内生细菌与腐植酸类物质混合生产的生物刺激素对甘蔗生产的影响。结果表明,叶面喷施生物刺激素比沟施效果好,且出苗后60天施用效果最佳,比对照增产37%。在第一年和第二年宿根蔗试验中,甘蔗产量分别提高了5%和24%,其中第一年试验过程中巴西东南部遭遇了严重干旱胁迫。 | Silézio Ferreira da Silva Fábio Lopes Olivares Luciano Pasqualoto Canellas 李双 | 2019 | 腐植酸2019，0，4： | 2 |
| 7 | Performance of Slope Behavior Indicators in Unsaturated Pyroclastic Soils显示文摘Landslide risk is increasing in many parts of the world due to growth of population and infrastructures. Therefore, an effort has to be made in developing new and cheap sensors for areas susceptible of landslides to continuously control the slope behaviour, until approaching failure conditions. The paper reported experimental data from smallscale physical models about the performance of Time Domain Reflectometry(TDR) and optical fibres, which act as the indicators of the incoming failure of slopes covered by unsaturated granular soils. Obtained results appear encouraging, since both sensors provide continuous information about the state of the slope, in terms of water content profiles and ongoing deformations, induced by rainwater infiltration, even immediately before the triggering of a fast landslide. | Luciano PICARELLI Emilia DAMIANO Roberto GRECO Aldo MINARDO Lucio OLIVARES Luigi ZENI | 2015 | Journal of Mountain Science2015，12，6： | 2 |
| 8 | Random im poant alterations in HIV-1 viral quasispecies after antiviral treatment 显示文摘 | Sanchez Palomino S Olivares I Yuste E | 1996 | Antivir Ther1996，，1： | 1 |
| 9 | Stability of anthocyanin-based aqueous extract of andean purple corn and redflushed sweet potato compared to synthetic and natural eolourants 显示文摘 | olivar A C C Cisveros-Zevallos L | 2004 | Food Chemistry2004，86，： | 1 |
| 10 | In vivo correetion of routine hereditary tyrosinemia type I by phiC31 integrase-mediated gene delivery 显示文摘 | Held P K Olivares E C Grompe M | 2005 | Mol Ther2005，11，3： | 1 |
| 11 | Effect of vascular endo-thelial growth factor inhibition on endometrial implant development ina murine model of endometriosis显示文摘 | Ricci AG Olivares CN Bilotas MA | 2011 | Reprod Sci2011，18，7： | 1 |
| 12 | Cracking control of concretes modified with short AR-glass fibers at early age, Experimental results on standard concrete and SCC 显示文摘 | Barluenga G Herndndez- Olivares F | 2007 | Cement and Concrete Research2007，37，12： | 1 |
| 13 | Evaluation of fungal-and photo-degradation as potential treatments for the removal of sunscreens BP3 and BPI 显示文摘 | GAGO-FERRERO P BADIA-FABREGAT M OLIVARES A | 2012 | Science of the Total Environment2012，427，15： | 1 |
| 14 | New rail steels for the 21st century显示文摘 | Robtes Hernandez F C Kalay Semih Ordonez Olivares R | 2008 | Railway Track and Structures2008，104，： | 1 |
| 15 | Site-specific genomic integration in mammalian cells mediated by phage φC31 integrase 显示文摘 | Thyagarajan B Olivares E C Hollis R P | 2001 | Mol Cell Biol2001，21，39： | 1 |
| 16 | Essentiality of copper in humans显示文摘 | UAUY R OLIVARES M MAURICIO G | 1998 | Am J Clin Nutr1998，，： | 1 |
| 17 | A phage integrase directs efficient site -specific integration in human cells显示文摘 | Groth AC Olivares EC Thyagarajan B | 2000 | Proc Natl Acad Sci USA2000，97，11： | 1 |
| 18 | Genetic determinants involved in the susceptibility of Pseudomo- nas aeruginosa to beta-lactam antibiotics显示文摘 | Alvarez-Ortega C Wiegand I Olivares J | 2010 | Antimicrobial Agents Chemother2010，54，10： | 1 |
| 19 | Antimicrobial susceptibility of Helicobacter pylori and mechanisms of clarithromycin resistance in strains isolated from patients in Uruguay显示文摘 | Torres-Debat M E Prez-Prez G Olivares A | 2009 | Rev Esp Enferm Dig2009，101，5： | 1 |
| 20 | Poorly controlled type 1 diabetes mellitus in young men selectively suppresses luteinizing hormone secretory burst mass 显示文摘 | Lopez-Alvarenga JC Zarifion T Olivares A | 2002 | J Clin Endocrinol Metab2002，87，12： | 1 |
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