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| 1 | Pancreatic regenerating protein (regⅠ) and regⅠreceptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis显示文摘AIM: Pancreatic regenerating protein (regⅠ) stimulates pancreatic regeneration after pancreatectomy and is mitogenic to ductal andβ-cells. This suggests that regⅠand its receptor may play a role in recovery after pancreatic injury. We hypothesized that regⅠand its receptor are induced in acute pancreatitis. METHODS: Acute pancreatitis was induced in male Wistar rats by retrograde injection of 3% sodium taurocholate into the pancreatic duct. Pancreata and serum were collected 12, 24, and 36 hours after injection and from normal controls (4 rats/group). RegⅠreceptor mRNA, serum regⅠprotein, and tissue regⅠprotein levels were determined by Northern analysis, enzyme-linked immunosorbent assay (ELISA), and Western analysis, respectively. Immunohistochemistry was used to localize changes in regⅠand its receptor. RESULTS: Serum amylase levels and histology confirmed necrotizing pancreatitis in taurocholate treated rats. There was no statistically significant change in serum regⅠconcentrations from controls. However, Western blot demonstrated increased tissue levels of regⅠat 24 and 36 h. This increase was localized primarily to the acinar cells and the ductal cells by immunohistochemistry. Northern blot demonstrated a significant increase in regⅠreceptor mRNA expression with pancreatitis. Immunohistochemistry localized this increase to the ductal cells, islets, and acinar cells. CONCLUSION: Acute pancreatitis results in increased tissue regⅠprotein levels localized to the acinar and ductal cells, and a parallel threefold induction of regⅠreceptor in the ductal cells, islets, and acinar cells. These changes suggest that induction of reg I and its receptor may be important for recovery from acute pancreatitis. | Martin H Bluth Sameer A Patel Brian K Dieckgraefe Hiroshi Okamoto Michael E Zenilman | 2006 | World Journal of Gastroenterology2006，12，28： | 19 |
| 2 | Proxy signature: Delegation of the power to sign messages 显示文摘 | MAMBO M USUDA K OKAMOTO E | 1996 | IEICE Transactions Fundamentals1996，79，9： | 1 |
| 3 | Proxy signature:delegation of the power to sign messages显示文摘 | MAMBO M USUDA K OKAMOTO E | 1996 | IEIGE Trans on Fundamentals1996，79，9： | 1 |
| 4 | Proxy signatures:delegation of the power to sign messages显示文摘 | MAMBO M USUDA K OKAMOTO E | 1996 | IEICE Trans Fundam1996，79，9： | 1 |
| 5 | Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin显示文摘 | Okamoto K Okamoto I Hatashita E | 2012 | Mol Cancer Ther2012，11，1： | 1 |
| 6 | Enantiomer separation of fungicidal triazolyl alcohols by normal phase HPLC on polysaccharide-based chiral stationary phase显示文摘 | SPITZER T YASHIMA E OKAMOTO Y | 1999 | Chirality1999，11，： | 1 |
| 7 | Abscisic acid and the control of seed dormancy and germination 显示文摘 | Nambara E Okamoto M Tatematsu K | 2010 | Seed Science Research2010，20，： | 1 |
| 8 | Proxy sig-natures:delegation of the power to sign messages显示文摘 | MAMBO M USUDA K OKAMOTO E | 1996 | IEICE Trans on Fundamentals1996，79，9： | 1 |
| 9 | Proxy signatures: delegation of the power to sign messages显示文摘 | Mambo M Usuda K Okamoto E | 1996 | IEICE Trans Fundam1996，79，9： | 1 |
| 10 | Metal ions dramatically enhance the enantioselectivity for lipase catalysed reactions in organic solvents 显示文摘 | OKAMOTO T YASUHITO E UEJI S | 2006 | Org Biomol Chem2006，4，6： | 1 |
| 11 | Proxy signatures:delegation of the power to sign messages 显示文摘 | Mambo M Usuda K Okamoto E | 1996 | IEICE Trans Fundam1996，79，9： | 1 |
| 12 | Proxy signatures delegation of the power to sign messages显示文摘 | Mambo M Usuda K Okamoto E | 1996 | lEICE Transactions on laundamentals1996，792，9： | 1 |
| 13 | Proxysignature:Delegation of the Power to Sign Messages显示文摘 | Mambo M Usuda K Okamoto E | 1996 | IEICE Trans on Fundamentals of Electronics Communications and Computer Sciences1996，79，09： | 1 |
| 14 | Faster Factoring of Integers of a Special Form 显示文摘 | Okamoto E Peralta R | 1996 | IEICE Transactionson Fundamentals of Electronics Communications and Computer Sciences1996，79，4： | 1 |
| 15 | Reflective and Transflective Color LCDs with Double Polarizers 显示文摘 | Macda T Matsushima T Okamoto E | 1999 | JSID1999，7，1： | 1 |
| 16 | Suppression of growth of hepatocellular carcinoma by sodium butyrate in vitro and in vivo显示文摘 | Yamamoto H Fujimoto J Okamoto E | 1998 | Int J Cancer1998，76，6： | 1 |
| 17 | Ovarian clear cell adenofibromatous tumor: report of 2 cases显示文摘 | Tsurunaga I Iwai E Okamoto Y | 1992 | Nippon Sanka Eujinka Gakkai Zasshi1992，44，1： | 1 |
| 18 | Polysaccharide-based chiral LC columns显示文摘 | Yashima E Yamamoto C Okamoto Y | 1998 | Synlett1998，，4： | 1 |
| 19 | (-)-Bornyl acetate induces autonomic relaxation and reduces arousal level after visual display terminal work without any influences of task performance in low-dose condition显示文摘 | Matsubara E Fukagawa M Okamoto T | 2011 | Biomed Res2011，32，2： | 1 |
| 20 | Proxy signature:delegation of the power to sign messages 显示文摘 | MAMBO M USUDA K OKAMOTO E | 1996 | IEICE Trans Fundamentals1996，79，9： | 1 |
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