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| 1 | 乳腺大号穿刺针活检的组织病理与乳腺X线照相的相互关系显示文摘 | loff.,OB Berg.,WA | 1999 | 世界医学杂志1999，3，3： | 9 |
| 2 | Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats显示文摘瞄准:测试假设这项活动的那改进他我有与周期性的肝损伤联系的纤维发生的过程的氧合酶罐头 interfere,我们调查了在表示上的治疗学的潜力他我在 CCl (4 ) 的 oxygense-1 劝诱了微榴状的肝硬化模型。方法:带老鼠 HO-1 或 GFP 基因的 Recombinant 联系 adeno 的病毒被产生。1x 10 (12 )联系 adeno 的病毒的 vg 在肝的正式就职的时候通过门注射被管理纤维变性。结果:有由 rAAV/HO-1 的 HO-1 的在表示上的老鼠肝显著地增加了的调节以一种稳定的方式的 HO 酶的活动。微榴状的肝硬化的开发显著地作为与控制相比在 rAAV/HO-1-transduced 动物被禁止。门静脉高血压显著地作为与控制相比在 rAAV/HO-1-transduced 动物被减少,而在收缩血压没有重要变化。这发现伴有激活的改进的肝生物化学,更少的渗透的巨噬细胞和更少在 rAAV/HO-1-transduced 肝的肝的星形细胞(HSC ) 。结论:改进惊讶在肝的活动压制肝硬化的发展。 | Tung-Yu Tsui Chi-Keung Lau Jian Ma Gabriel Glockzin Aiman Obed Hans J Schlitt Sheung-Tat Fan | 2006 | World Journal of Gastroenterology2006，12，13： | 9 |
| 3 | 艾滋病合并隐球菌脑膜炎18例临床分析显示文摘目的 提高对艾滋病 (AIDS)合并隐球菌脑膜炎的认识。方法 对赤道几内亚巴塔地区医院 18例AIDS合并隐球菌脑膜炎患者进行临床综合分析。结果 18例AIDS合并隐球菌脑膜炎患者的临床主要表现为 :发热、剧烈头痛、极度乏力、肢体痛、脑膜刺激征及消瘦与脱水等。脑脊液 (CSF)培养均为新型隐球菌生长 ;涂片及隐球菌多糖荚膜抗原 (ELISA法 )检测的阳性率分别为 77 8% (14/ 18) ,94 4% (17/ 18)。结论 隐球菌脑膜炎为AIDS常见机会性感染及主要致死病因之一。 | 王文琦 Micha ST Justino OB | 2000 | 中国实用内科杂志2000，20，11： | 8 |
| 4 | Survival benefit in patients after palliative resection vs non-resection colon cancer surgery显示文摘AIM: To evaluate survival in patients undergoing pallia- tive resection versus non-resection surgery for primary colorectal cancer in a retrospective analysis. METHODS: Demographics, TNM status, operating de- tails and survival were reviewed for 67 patients under- going surgery for incurable colorectal cancer. Palliative resection of the primary tumor was performed in 46 cases in contrast to 21 patients with non-resection of the primary tumor and bypass surgery. Risk factors for post- operative mortality and poor survival were analyzed with univariate and multivariate analyses.RESULTS: The two groups were comparable in terms of age, gender, preoperative presence of ileus and tumor stage. Multivariate analysis showed that median survival was significantly higher in patients with palliative resec- tion surgery (544 vs 233 d). Differentiation of the tumor and tumor size were additional independent factors that were associated with a significantly poorer survival rate. CONCLUSION: Palliative resection surgery for primary colorectal cancer is associated with a higher median survival rate. Also, the presence of liver metastasis and tumor size are associated with poor survival. Therefore, resection of the primary tumor should be considered in patients with non-curable colon cancer. | A Beham M Rentsch K Püllmann L Mantouvalou H Spatz HJ Schlitt A Obed | 2006 | World Journal of Gastroenterology2006，12，41： | 5 |
| 5 | Application of Ordinary Kriging in Mapping Soil Organic Carbon in Zambia显示文摘The quantification of the pattern and spatial distribution of soil organic carbon(SOC) is fundamental to understand many ecosystem processes. This study aimed to apply ordinary kriging(OK) to model the spatial distribution of SOC in a selected part of Zambia. A total of 100 soil samples were collected from the study area and analyzed for SOC by determining soil oxidizable carbon using the Walkley-Black method. An automated fitting procedure was followed when modeling the spatial structure of the SOC data with the exponential semivariogram. The results indicated that the short range spatial dependence of SOC was strong with a nugget close to zero. The spatial autocorrelation was high to medium with a nugget to sill ratio of 0.25. The root mean square error of the predictions was 0.64, which represented 58.18% of the mean observed data for SOC. It can be concluded that the generated map could serve as a proxy for SOC in the region where evidence of spatial structure and quantitative estimates of uncertainty are reported.Therefore, the maps produced can be used as guides for various uses including optimization of soil sampling. | Lydia Mumbi CHABALA Augustine MULOLWA Obed LUNGU | 2017 | Pedosphere2017，27，2： | 5 |
| 6 | Drugging in the absence of p53显示文摘Inactivation of the p53 gene is a key driver of tumorigenesis in various cancer cohorts and types.The quest for a successful p53-based therapy that holds the promise of treating more than half of the cancer population has culminated in extensive knowledge about the role and function of p53 and led to new proposed innovative strategies against p53-defective cancers.We will discuss some of these latest studies with a focus on metabolic regulation and DNA damage response and also highlight novel functions of p53 in these pathways that may provide a contemporary rationale for targeting p53 loss in tumors. | Obed Akwasi Aning Chit Fang Cheok | 2019 | Journal of Molecular Cell Biology2019，11，3： | 4 |
| 7 | Analysis of TRPA1 antagonist,A-967079,in plasma using high-performance liquid chromatography tandem mass-spectrometry显示文摘The noxious effects from exposure to toxic inhalation hazards(TIHs,such as isocyanates,chlorine,etc.)are known to be triggered by the activation of transient receptor potential ankyrin 1(TRPA1)ion channel.Antagonists of TRPA1 have shown near complete attenuation of the noxious effects from TIH exposure.One of the TRPA1 antagonists,(1E,3E)-1-(4-fluorophenyl)-2-methyl-1-pentene-3-one oxime(A-967079),has shown impressive efficacy,high selectivity,high potency,and oral bioavailability.Although a vali-dated method to quantify A-967079 in biological matrices is vital for the further development of A-967079 as a therapeutic agent,no method for its analysis from any matrix is currently available.Hence,a rapid and simple HPLC-MS/MS method was developed and validated to quantify A-967079 in rabbit plasma.The method presented here features an excellent LOD of 25 nM and a wide linear range(0.05-200μM),with good accuracy and precision(100±10.5%and<14.2%relative standard deviation,respectively).The stability of A-967079 in plasma was excellent for most of the storage conditions evaluated.The method was successfully applied to determine A-967079 from treated animals and it may facilitate the development of this TRPA1 antagonist as a therapeutic agent against the noxious effects of TIH exposure. | Obed A.Gyamfi Nesta Bortey-Sam Abigail B.Donkor Carl W.White Brian A.Logue | 2020 | Journal of Pharmaceutical Analysis2020，10，2： | 2 |
| 8 | Abortifacient Potential of Aqueous Extract of Senna alata Leaves in Rats显示文摘Objective To study the abortifacient activity of aqueous extract of Senna alata leaves in female Wistar rats.Methods Pregnant rats weighing 143.65 ± 13.11 g were completely randomized into 5 groups(A-E).Rats in group A(negative control) were orally administered,once daily with 0.5 ml of distilled water on days 10-18 post-coitum while those in groups B,C,D,and E were treated exactly like the negative control except they received the same volume containing 2.85 mg/kg body weight of mifepristone(group B,reference drug),250,500 and 1 000 mg/kg body weight of the extract respectively(groups C-E).Results Phytochemical screening of the extract showed positive results for saponins(1.22%),flavonoids(1.06%),cardiac glycosides(0.20%),cardenolides and dienolides(0.18%),phenolics(0.44%) and alkaloids(0.52%).Respiratory distress,salivation,diarrhoea,changes in the appearance of hair as well as maternal mortality were not observed at any time during the exposure period except in the mifepristone-treated animals where there was episode of diarrhoea and tiredness.The extract significantly reduced(P<0.05) the number of life foetus,weight and survival ratio of the foetus,numbers of implantations and Corpora lutea,implantation index,progesterone,prolactin,estradiol,follicle stimulating and luteinizing hormones whereas the number of dead foetus,number and percentage of rats that aborted,percentage vaginal opening,resorption index,pre-and post-implantation losses increased significantly.In addition,mifepristone-treated animals produced resorption index that compared well with the distilled water control.There was also no dead or life foetus and serum progesterone concentration was increased in the animals treated with mifepristone.All cases of abortion were accompanied with vaginal bleeding.Although,the final weight of the rats increased significantly,the feed and water intake were not significantly altered in all the treatment groups.The weight of the uterus,uterine-body weight ratio,length of the right uterus horn and uterine cholesterol decreased significantly in all the treatment groups.The uterine alkaline phosphatase activity and glucose concentration increased in only the extract-treated animals whereas mifepristone decreased the uterine alkaline phosphatase activity and glucose content of the animals.Conclusion This study has provided evidence to the age-long claim of S.alata leaves in 'washing the uterus'.The abortifacient properties were most pronounced at 500 and 1 000 mg/kg body weight of the extract and were similar to the animals treated with 2.85 mg/kg body weight of mifepristone.Hormonal influence,changes in implantation site,estrogenicity and uterogenicity are suggested as possible mechanism of abortifacient activity of aqueous extract of S.alata leaves.Overall,the extract may be used as an abortifacient especially at 500 and 1 000 mg/kg body weight and therefore not safe for consumption as oral remedy during pregnancy. | Yakubu MT Adeshina AO Oladiji AT Akanji MA Oloyede OB Jimoh GA Olatinwo AWO Afolayan AJ | 2010 | Journal of Reproduction and Contraception2010，21，3： | 2 |
| 9 | Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients显示文摘Alcoholic liver disease(ALD) is the second most common diagnosis among patients undergoing liver transplantation(LT).The recovery results of patients transplanted for ALD are often at least as good as those of patients transplanted for other diagnoses and better than those suffering from hepatitis C virus, cryptogenic cirrhosis, or hepatocellular carcinoma.Inthe case of medically non-responding patients with severe acute alcoholic hepatitis or acute-on chronic liver failure, the refusal of LT is often based on the lack of the required alcohol abstinence period of six months.The obligatory abidance of a period of abstinence as a transplant eligibility requirement for medically non-responding patients seems unfair and inhumane, since the majority of these patients will not survive the six-month abstinence period.Data from various studies have challenged the 6-mo rule, while excellent survival results of LT have been observed in selected patients with severe alcoholic hepatitis not responding to medical therapy.Patients with severe advanced ALD should have legal access to LT.The mere lack of pre-LT abstinence should not be an obstacle for being listed. | Aiman Obed Steffen Stern Anwar Jarrad Thomas Lorf | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 10 | Correlation of proliferation indices, apoptosis, and related oncogene expression (bcl 2 and c erbB 2) and p53 in proliferative, hyperplastic, and malignant endometrium 显示文摘 | Ioffe OB Papadimitriou JC Drachenberg CB | 1998 | Hum Pathol1998，29，10： | 1 |
| 11 | Bombesin attenuates pre-mRNA splicing of glucocorticoid receptor by regulating the expression of serine-arginine protein p30c(SRp30c)in prostate cancer cells显示文摘 | Zhu J Gong JY Goodman OB Jr | 2007 | Biochim Biophys Acta2007，1773，7： | 1 |
| 12 | Clients of female sex workers in Nyanza province , Kenya : a core group in STD/HIV transmission显示文摘 | Voeten HA Egesah OB Ondiege MY | 2002 | Sex Transm Dis2002，29，： | 1 |
| 13 | The value of cord blood interleu- kin-6 lecels for prediction chorioamnionitis, funisitis and neonatal infec- tion in term premature ruptrue of membranes 显示文摘 | Tacsi Y Dilbaz B Uzmez OB | 2006 | Eur J Obstet Gynecol Reprod Biol2006，128，： | 1 |
| 14 | Dexmedetomidine and postoperativeshivering in patients undergoing elective abdominal hysterectomy显示文摘 | Elvan EG OB Uzun S | 2008 | Eur J Anaesthesiol2008，25，5： | 1 |
| 15 | Social support and incentives programme for patients with tuberculosis:experience from the Russian Federation显示文摘 | Jakubowiak WM Bogorodskaya EM Borisov SE Danilova ID Lomakina OB Kourbatova EV | 2007 | Iut J Tuberc Lung Dis2007，11，11： | 1 |
| 16 | Direct Composite Coronal Reconstructionof Two Fractured Incisors:an 8-year Follow-up显示文摘 | De La Pefia VA Cabrita OB | 2005 | Dent Traumatol2005，21，5： | 1 |
| 17 | Characterization and stability of N- terminally PEGyiated rhG- CSF显示文摘 | Kinstler OB Brems DN Lauren SL | 1996 | Pharm Res1996，13，： | 1 |
| 18 | Treatment of chronic hand dermatoses with UVB-TL01显示文摘 | Nordal E J Chistensen OB | 2004 | Act derm venereal2004，84，4： | 1 |
| 19 | Breast cancer care: Patient in- formation and communication as a preventive educational process 显示文摘 | Sabine HK Dirk OB Gotz S | 2006 | Breast Care2006，1，6： | 1 |
| 20 | Laparoscopic versus open appendectomy in complicated appendicitis :a review of the NSQIP database显示文摘 | Tuggle KR Ortega G Bolorunduro OB | 2010 | J Surg Res2010，163，2： | 1 |
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