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| 1 | Development of an antibody that neutralizes soluble IgE and eliminates IgE expressing B cells显示文摘免疫球蛋白 E (IgE ) 在过敏气喘起一个关键作用并且是为 monoclonal 抗体的一个临床上验证的目标。治疗学的 anti-IgE 抗体块在 IgE 和 Fc epsilon 之间的相互作用(Fcε) 受体,它消除或最小化,但是做过敏显型不典型地由 B 房间削减 IgE 的进行中的生产。我们产生了有潜力抵销可溶的 IgE 并且通过抗体依赖者消除表示 IgE B 房间的高亲密关系的 anti-IgE 抗体(MEDI4212 ) 调停房间的 cytotoxicity。MEDI4212 变体被产生在 fucosylation 在抗体或改变的 Fc 区域包含变化以便为 Fcγ 提高抗体亲密关系; RIIIa。所有 MEDI4212 变体与比得上的亲密关系跳了到人的 IgE 野类型(WT ) 抗体。每变体被显示禁止在 IgE 和 Fcε 之间的相互作用; RI,它翻译了成 Fcγ 的有势力抑制;调停 RI 的功能回答。重要地,所有变体在表示房间的膜 IgE 的表面同样跳了到 IgE。然而, MEDI4212 变体为 Fcγ 表明了提高的亲密关系;包括在位置 158 点的多态的变体的 RIIIa。在 Fcγ 的改进;导致的 RIIIa 绑定在用两个都设计的房间线和类的基于的试金交换了的房间增加了受动器功能人的 IgE B 房间。通过它 IgE 的优异抑制,我们预计那受动器功能提高了 MEDI4212 也许能抵销可溶的 IgE 的高水平并且在他们区分并且变得 IgE secreting 血浆房间以前,由消除表示 B 房间的 IgE 提供增加的长期的利益。 | Andrew C. Nyborg Anna Zacco Rachel Ettinger M. Jack Borrok Jie Zhu Tom Martini Rob Woods Christine Kiefer Michael A. Bowen E. Suzanne Cohenz Ronald Herbst Herren Wu Steven Coats | 2016 | Cellular & Molecular Immunology2016，13，3： | 3 |
| 2 | Wear Evaluation on Ni_3Al/MnS Composite Related to Metallurgical Processes显示文摘Iron alloyed Ni3Al with composition of Ni-18.8Al-10.7Fe-0.5Mn-0.5Ti-0.2B in atom percent (NAC alloy) showed attractive tribological properties under unlubrication condition at room temperature.The alloy was prepared by hot isostatic pressing (HIP) process.The wear properties were associated with its intrinsic deformation mechanism.Unfortunately,the single phase NAC-alloy worked inadequately with its counterpart disk,and also showed a poor machinability.In the present work,NAC-alloy matrix composite with 6% (volume percent) MnS particle addition was studied to improve its wear behaviors and performance on machining.Two metallurgical processes of HIP and vacuum casting were applied to produce the testing materials.Pin-on-disk (POD) measurements were carried out at room temperature.A commercial vermicular graphite cast iron was selected as a reference material.The counterpart disk was made of a grey cast iron as liner material in ship engines.The contact pressures of 2.83 MPa and 5.66 MPa were normally applied in the tests.The investigation indicated that MnS particle addition in the NAC-alloy composites functions as an effective solid lubricant,and improved wear properties and machinability of the materials.Obviously,as-cast NAC-alloy with in-situ formed MnS-phase was working more effectively with the counterpart,comparing to the HIPed NAC-alloy composite with MnS particles.At the high contact pressure of 5.66 MPa,the specific wear rate of the as-cast NAC-alloy composite was high.The phenomenon of the negative effect is mostly due to the brittle second NiAl phase as evidenced in the microstructure analysis. | Karin Gong LUO He-li ZHOU Zhi-feng TIAN Zhi-ling Lars Nyborg LI Chang-hai | 2012 | Journal of Iron and Steel Research(International)2012，19，7： | 2 |
| 3 | Ligh fraction organic N,ammonium,nitrate and total N in a thin black chernozemic soil under bromegrass after 27 annual applications of different N rates显示文摘 | Malhi S S Harapiak J T Nyborg M | 2003 | Nutritient Cycling in Agroecosystem2003，65，： | 1 |
| 4 | Comparison of controlled-release nitrogen Fertilizers on turfgrass in a moderate temperature area 显示文摘 | Zhang M Nyborg M | 1998 | Hort Science1998，33，7： | 1 |
| 5 | Accuracy of field sampling for soil tests显示文摘 | Nyborg M Toogood J A | 1971 | Can J Soil Science1971，51，： | 1 |
| 6 | Comparison of controlled-release nitrogen Fertilizers on turfgrass in a moderate temperature area显示文摘 | Zhang M Nyborg M | 1998 | Hortisience1998，33，7： | 1 |
| 7 | Acoustic emission monitoring of steel railroad bridges 显示文摘 | Gong Z Nyborg E O Oommen G | 1992 | Materials Evaluation1992，50，6： | 1 |
| 8 | Effects of long-term N fertiliz- er-induced acidification and liming on micronutrients in soil and in bromegrass hay 显示文摘 | Malhia S S Nyborg M Harapiak J T | 1998 | Soil and Tillage Research1998，48，： | 1 |
| 9 | Immediate effects of topsoil removal on crop productivity loss and its restoration with commercial fertilizers显示文摘 | lzaurralde R C Solberg E D Nyborg M | | 0，，3： | 1 |
| 10 | Grassland soil as affected by 27 annual applications of six rates of fertilizer N 显示文摘 | Malhi S S Harapiak J T Nyborg M | 2003 | Nutrient Cycling in Agroecosystems2003，66，： | 1 |
| 11 | Accuracy of Field Sampling for Soil Tests显示文摘 | CAMERON D R NYBORG M TOOGOOD J A | 1971 | Can J Soil Sci1971，51，： | 1 |
| 12 | A mechanistic model for CO2 corrosion with protective iron carbonate films 显示文摘 | Nesic S Nordsveen M Nyborg R Stangeland A | 2009 | Corrosion2009，39，6： | 1 |
| 13 | Elongation factors in protein biosynthesis显示文摘 | Andersen Cr Nissen P Nyborg J | 2003 | Trends Bio Sci2003，28，： | 1 |
| 14 | Ultrasound: It's chemical, biological and physical effects显示文摘 | SUSLICK K S NYBORG W L | 1990 | The Journal of the Acoustical Society of America1990，87，2： | 1 |
| 15 | Tillage and N source influence soil-emitted nitrous oxide in the Alberta Parkland region 显示文摘 | Lemke R L Izaurralde R C Nyborg M | 1999 | Caaadian Journal Soil Science1999，79，1： | 1 |
| 16 | Acoustic streaming near a boundary显示文摘 | NYBORG W L | 1958 | J Acoust Soc Am1958，30，4： | 1 |
| 17 | Intramembrane proteolytie cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase 显示文摘 | Nyborg AC Ladd TB Jansen K | 2006 | FASEB J2006，20，10： | 1 |
| 18 | Divisible good auctions: The role of allocation rules显示文摘 | Kremer I Nyborg K | 2004 | The Rand Journal of Economics2004，35，2： | 1 |
| 19 | Underpricing and market power in uniform price auctions 显示文摘 | Kremer I Nyborg K | 2004 | Review of Financial Studies2004，17，1： | 1 |
| 20 | Seasonal distribution of nitrous oxide emissions from soils in the Parkland region 显示文摘 | Lemke R L Izaurralde R C Nyborg M | 1998 | Soil Science Society of America Journal1998，62，5： | 1 |
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