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| 1 | Enhancement of Extracts from Celastrus orbiculatus on Maturation and Function of Dendritic Cells in vitro and in vivo显示文摘Objective To examine the immunoregulation of Celastrus orbiculatus extracts (COE), a traditional Chinese medicine, on maturation and function of dendritic cells (DCs) in vitro and in vivo. Methods In vitro, after treated with COE in different nontoxic concentrations (0, 10, 20, 40, 80, and 160 μg/mL) for 5 d, the surface immunological molecules and cytokine secretion of mice bone marrow-derived DCs in response to COE were analyzed by flow cytometric analysis (FACS) and enzyme linked immunosorbent assay (ELISA), respectively. In vivo, mouse hepatoma cells (Hepa1-6, 1 × 106) were injected sc and were treated with different dosages of COE (10, 20 or 40 mg/kg/d). Effects on tumor growth were determined by tumor volume and histology analysis after 28 d administration of COE. The relative proportions of mature DCs and CD8+ T cells were measured in mononuclear cells that had been isolated from spleen by FACS. Results COE stimulated IL-2 and IFN-γ secretion of DCs, simultaneously enhanced the maturation of DCs by enhancing immunological molecule (CD40, CD80, CD86, H-2Kb, and I-Ab) expression in a dose-dependent manner. Furthermore, the chemotactic responses of DCs were significantly higher in COE-treated than untreated DCs, in association with higher chemokine receptor 7 expression. Furthermore, COE increased DCs produce IFN-γ and IL-2 in a dose-dependent manner when the concentration of COE less than 40 μg/mL, decreased DCs produce IL-10 and IL-4 also in a dose-dependent manner. In in vivo studies, COE can not only suppress growth of malignant hepatocellular carcinomas but also stimulate maturation of DCs, associated with strongly enhanced CD8+ CTL responses. Conclusion These data provide new insight into the mechanism of action of COE and indicate that the stimulation of maturation and function of DCs by COE contributes to its immunoregulatory effects. | QIAN Ya-yun1, ZHANG Hua2, YUAN Lin1,3, HOU Ying1, LIU Wei-wei1, LIU Yan-qing1 1. Institute of Traditional Chinese Medicine & Western Medicine, Yangzhou University, Yangzhou 225009, China 2. Department of nursing, Medical College, Yangzhou University, Yangzhou 225009, China 3. Department of Image, 97th Hospital of People’s Liberation Army, Xuzhou 221000, China | 2010 | Chinese Herbal Medicines2010，2，3： | 4 |
| 2 | A Long Twentieth Century of the Cell Cycle and Beyond显示文摘 | Paul Nurse | 2000 | Cell2000，，1： | 3 |
| 3 | Traditional Chinese Medicine Nursing Protocols for Diabetic Nephropathy显示文摘As a dreaded consequence of diabetes mellitus (DM),diabetic nephropathy (DN)accounts for about 40%of end-stage renal disease (ESRD). It is a universal cause of ESRD,and can be considered as an independent risk factor for cardiovascular disease. In recent years,TCM has show n its unique advantages in the treatment of DN. As one of the chronic diseases caused by living styles,DN has the higher requirements for nursing. Nevertheless,TCM nursing based on syndrome differentiation can provide the personalized guidance for the patients w ith DN according to different syndrome patterns and symptoms. Therefore,this article mainly explored the key points of common syndromes,TCM nursing methods and health guidance of DN in order to further develop the advantages of TCM,improve its efficacy and standardized its nursing behavior. | Editorial Board of Nursing of Integrated Traditional Chinese and Western Medicine | 2018 | 中西医结合护理(中英文)2018，4，9： | 3 |
| 4 | The problem of assessing effective neuroprotection in experimental cerebral ischemia显示文摘 | Corbett D Nurse S | | 0，，： | 2 |
| 5 | Infusion Nursing Standards of Practice显示文摘 | Infusion Nurses Society | 2006 | J Iufus Nurs2006，29，1： | 1 |
| 6 | 4th ed, Brunner, Liltian Sholtis显示文摘 | The lippincott manual of nursing practice | 1986 | TAPSCO Inc1986，571，： | 1 |
| 7 | A vision of baccalaureate and graduate nursing education: the next decade显示文摘 | American Association of Colleges of Nursing | 1999 | J Prof Nurs1999，15，1： | 1 |
| 8 | Universal control mechanism regulating onset of M-phase 显示文摘 | Nurse P | 1990 | Nature1990，344，6266： | 1 |
| 9 | Nurses say health and safety concerns play a major role in employment decisions显示文摘 | American Nurses Association | 2002 | Adv Nurs2002，37，5： | 1 |
| 10 | Infusion nursing standards of practice 显示文摘 | Infusion Nurses Society | 2011 | Journal of Infusion Nursing2011，30，3： | 1 |
| 11 | Shoe inserts and orthotics for sport and physical activities显示文摘 | Nigg B M Nurse M A Stefanyshyn DJ | 1999 | Med Sci Sports Exe1999，31，7： | 1 |
| 12 | A long twentieth century of the cell cycle and beyond显示文摘 | Nurse P | 2000 | Cell2000，100，1： | 1 |
| 13 | Revised Intravenous nursing standards of practice显示文摘 | Intravenous Nurses Society | 1998 | Journal of Intravenous Nursing1998，21，1： | 1 |
| 14 | Intravenous nursing standards of praetiee显示文摘 | Intravenous Nurses Society | 1998 | J Intraven Nurs1998，21，1： | 1 |
| 15 | Intravenous nursing standards of prac tice显示文摘 | Intravenous Nurses Society | 1998 | Intravenous Nursing1998，，： | 1 |
| 16 | Essentials of college and university educa- tion for professional nursing显示文摘 | American Association of Colleges of Nursing | 1987 | J Prof Nurs1987，3，1： | 1 |
| 17 | Full-field automated photoelasticity by use of a threewavelength approach to phase stepping显示文摘 | Nurse A D | 1997 | Appl Opt1997，36，23： | 1 |
| 18 | Scabies returns--mas- sively显示文摘 | Problems in nursing homes for the aged | 2002 | J Krankenpfl2002，40，12： | 1 |
| 19 | New superelements for singular derivative problems of arbitrary order 显示文摘 | NURSE A D | 2001 | International Journal for Numerical Methods in Engineering2001，50，1： | 1 |
| 20 | Infusion nursing standards of practice 显示文摘 | Infusion Nurses Society | 2011 | J InfusNurs2011，34，1： | 1 |
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