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| 1 | New insight in expression, transport, and secretion of brain-derived neurotrophic factor: Implications in brainrelated diseases显示文摘Brain-derived neurotrophic factor(BDNF) attracts increasing attention from both research and clinical fields because of its important functions in the central nervous system. An adequate amount of BDNF is critical to develop and maintain normal neuronal circuits in the brain. Given that loss of BDNF function has beenreported in the brains of patients with neurodegenerative or psychiatric diseases, understanding basic properties of BDNF and associated intracellular processes is imperative. In this review, we revisit the gene structure, transcription, translation, transport and secretion mechanisms of BDNF. We also introduce implications of BDNF in several brain-related diseases including Alzheimer's disease, Huntington's disease, depression and schizophrenia. | Naoki Adachi Tadahiro Numakawa Misty Richards Shingo Nakajima Hiroshi Kunugi | 2014 | World Journal of Biological Chemistry2014，5，4： | 30 |
| 2 | Functional interactions between steroid hormones and neurotrophin BDNF显示文摘Brain-derived neurotrophic factor(BDNF),a critical neurotrophin,regulates many neuronal aspects including cell differentiation,cell survival,neurotransmission,and synaptic plasticity in the central nervous system(CNS) .Though BDNF has two types of receptors,high affinity tropomyosin-related kinase(Trk) B and low affinity p75 receptors,BDNF positively exerts its biological effects on neurons via activation of TrkB and of resultant intracellular signaling cascades including mitogenactivated protein kinase/extracellular signal-regulated protein kinase,phospholipase Cγ,and phosphoinositide 3-kinase pathways.Notably,it is possible that alteration in the expression and/or function of BDNF in the CNS is involved in the pathophysiology of various brain diseases such as stroke,Parkinson's disease,Alzheimer's disease,and mental disorders.On the other hand,glucocorticoids,stress-induced steroid hormones,also putatively contribute to the pathophysiology of depression.Interestingly,in addition to the reduction in BDNF levels due to increased glucocorticoid exposure,current reports demonstrate possible interactions between glucocorticoids and BDNF-mediated neuronal functions. Other steroid hormones,such as estrogen,are involved in not only sexual differentiation in the brain,but also numerous neuronal events including cell survival and synaptic plasticity.Furthermore,it is well known that estrogen plays a role in the pathophysiology of Parkinson's disease,Alzheimer's disease,and mental illness,while serving to regulate BDNF expression and/or function.Here,we present a broad overview of the current knowledge concerning the association between BDNF expression/function and steroid hormones(glucocorticoids and estrogen). | Tadahiro Numakawa Daisaku Yokomaku Misty Richards Hiroaki Hori Naoki Adachi Hiroshi Kunugi | 2010 | World Journal of Biological Chemistry2010，1，5： | 7 |
| 3 | Impact of glucocorticoid on neurogenesis显示文摘Neurogenesis is currently an area of great interest in neuroscience.It is closely linked to brain diseases,including mental disorders and neurodevelopmental disease.Both embryonic and adult neurogeneses are influenced by glucocorticoids secreted from the adrenal glands in response to a variety of stressors.Moreover,proliferation/differentiation of the neural stem/progenitor cells(NSPCs)is affected by glucocorticoids through intracellular signaling pathways such as phosphoinositide 3-kinase(PI3K)/Akt,hedgehog,and Wnt.Our review presents recent evidence of the impact of glucocorticoids on NSPC behaviors and the underlying molecular mechanisms;this provides important information for understanding the pathological role of glucocorticoids on neurogenesis-associated brain diseases. | Haruki Odaka Naoki Adachi Tadahiro Numakawa | 2017 | Neural Regeneration Research2017，12，7： | 4 |
| 4 | MCI 186 prevents brain tissue from neuronal damage in cerebral infarction through the aetivation of intracellular signaling显示文摘 | Niyaz M Numakawa T Matsuki Y | 2007 | J Neurosei Res2007，85，13： | 1 |
| 5 | MicroRNA function and neurotrophin BDNF 显示文摘 | Numakawa T Richards M Adachi N | 2011 | Neuroehem Int2011，59，5： | 1 |
| 6 | Glucocorticoid suppresses BDNF -stimulated MAPK/ERK pathway via inhibiting interaction of Shp2 with TrkB 显示文摘 | Kumamaru E Numakawa T Adachi N | 2011 | FEBS Lett2011，585，20： | 1 |
| 7 | BDNF function and intracel- lular signaling in neurons显示文摘 | Numakawa T Suzuki S Kumamaru E | 2010 | Histol Histopatho12010，25，2： | 1 |
| 8 | BDNF function and intracellular signaling in neurons显示文摘 | Numakawa T Suzuki S Kumamaru E | 2010 | Histol Histopathol2010，25，2： | 1 |
| 9 | BDNF function and intracellular signaling in neurons显示文摘 | Numakawa T Suzuki S Kumamaru E | 2010 | Histol Histopathol2010，25，23： | 1 |
| 10 | BDNF function and intraeellular signaling in neurons显示文摘 | NUMAKAWA T SUZUKI S KUMAMARU E | 2010 | Histol Histopathol2010，25，2： | 1 |
| 11 | Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia显示文摘 | Numakawa T Yagasaki Y Ishimoto T | 2004 | Hum Mol Genet2004，113，27： | 1 |
| 12 | Chronic restraint stress causes anxiety-and depression-like behaviors,downregulates glucocorticoid receptor expression,and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex显示文摘 | Chiba S Numakawa T Ninomiya M | 2012 | Prog Neuropsychopharmacol Biol Psychiatry2012，39，1： | 1 |
| 13 | BDNF function and intracellular signaling in neurons显示文摘 | Numakawa T Suzuki S Kumamaru E | 2010 | His- tol Histopathol2010，25，2： | 1 |
| 14 | MCI-186 prevents brain tissue from neuronal damage in cerebral infarction through the activation of intracellular signaling显示文摘 | Niyaz M Numakawa T Matsuki Y | 2007 | J Neruosci Res2007，85，13： | 1 |
| 15 | Chronic antidepressants potentiate via sigma-1 receptors the brain- derived neurotrophic factor-induced signaling for gluta- mate release 显示文摘 | Yagasaki Y Numakawa T Kumamaru E | 2006 | J Biol Chem2006，281，12： | 1 |
| 16 | Protective action of neurotrophic factors and estrogen against oxidative stressmediated neurodegeneration显示文摘 | Numakawa T Matsumoto T Numakawa Y Richards M Yamawaki S Kunugi H | | 0，，2011： | 1 |
| 17 | BD-NF function and intracellular signaling in neurons显示文摘 | Numakawa T Suzuki S Kumamaru E | 2010 | Histol Histopathol2010，25，2： | 1 |
| 18 | Glucocortieoid attenuates brain-derived neurotrophie factor-dependent upregulation of glutamate receptors via the suppression of microRNA-132 expression 显示文摘 | Kawashima H Numakawa T Kumamam E | 2010 | Neumscienee2010，165，4： | 1 |
| 19 | BDNF function and intracellular signaling in neurons显示文摘 | Numakawa T Suzuki S Kumamaru E | 2010 | Histology&Histopathology2010，25，2： | 1 |
| 20 | Behavioral and molecular evidence for psychotropic effects in L-theanine显示文摘 | Wakabayashi C Numakawa T Ninomiya M | 2012 | Psychopharmacology2012，219，4： | 1 |
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