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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Role of zinc during hamster sperm capacitation显示文摘 | Andrews J C Nolan J P Hammerstedt R H | 1994 | Biology of Reproduction1994，51，： | 1 |
| 3 | P300 scalp amplitude distribution as an index of deception in a simulated cognitive deficit model显示文摘 | ROSENFELD J P ELLWANGER J W NOLAN K | 1999 | International Journal of Psychophysiology1999，33，1： | 1 |
| 4 | Suspension array technology:evolution of the flat-array paradigm显示文摘 | NOLAN LARRY A S | 2002 | Trends in Biotechnology2002，20，1： | 1 |
| 5 | Kinetics of allantoin metabolism in sheep 显示文摘 | KAHN L P NOLAN J V | 2000 | British Journal of Nutrition2000，84，： | 1 |
| 6 | The measurement of intra-abdominal pressure as a criterion for abdominal re- exploration显示文摘 | Kron I L Harman P K Nolan S P | 1984 | Ann Surg1984，199，1： | 1 |
| 7 | Variability of EGRET Gamma-ray sources 显示文摘 | Nolan P L Tompkins W F Grenier I A | 2003 | Astrophys J2003，597，1： | 1 |
| 8 | Cyclostationary signa- tures in practical cognitive radio applications 显示文摘 | SUTrON P D NOLAN K E DOYLE L E | 2008 | IEEE Journal on Selected Areas in Communications2008，26，1： | 1 |
| 9 | The Constructive, Destructive, and Reconstructive Power of Social Norms 显示文摘 | Schuhz P W Nolan J M Cialdini R B | 2007 | Psychological Science2007，18，5： | 1 |
| 10 | The role of intestinal endotoxin in liver iniury:a long and evolving history 显示文摘 | NOLAN J P | 2010 | Hepatology2010，52，： | 1 |
| 11 | The ProSeal laryngeal mask airway: a review of the literature显示文摘 | COOK T M LEE G NOLAN J P | 2005 | Can J Anaesth2005，52，7： | 1 |
| 12 | Near-surface moisture gradients and in situ permeation tests显示文摘 | Basheer P A M Nolan 1 | 2001 | Construction and Building Materials2001，15，23： | 1 |
| 13 | Cumulative exposure to tamoxifen:DNA ad-ducts and liver cancer in the rat显示文摘 | Carthew P Lee PN Edwards RE Heydon RT Nolan BM Martin EA | 2001 | Arch Toxicol2001，75，6： | 1 |
| 14 | Discussions on the use of fine water sprays or mists for fire suppression显示文摘 | A Jones P F Nolan | 1995 | Journal of Loss Prevention in the Process Industries1995，8，1： | 1 |
| 15 | Techno- economic Heritage, Pat- terns of Development, and the Advantage of Backwardness 显示文摘 | Nolan P D Lenski G | 1985 | Social Forces1985，64，2： | 1 |
| 16 | Cognitive Radio: Ten Years of Experimentation and Development 显示文摘 | PAWELCZAK P NOLAN K DOYLE L | 2011 | IEEE Communications Magazine2011，49，3： | 1 |
| 17 | Cyclostationary sig - natures in practical cognitive radio applications 显示文摘 | Sutton P Nolan K Doyle L | 2008 | IEEE JSAC2008，26，1： | 1 |
| 18 | Electromyogram Median Frequency, Spectral Compression and Muscle Fiber Conduction Velocity during Sustained submaximal Contraction of the Brachioradialis Muscle显示文摘 | M LOWERY P NOLAN M O'Malley | 2002 | J Electromyography Kinesiol2002，12，： | 1 |
| 19 | Near-surface moisture gradients and in situ permeation tests 显示文摘 | BASHEER P A M NOLAN E | 2001 | Construc- tion and Building Materials2001，，15： | 1 |
| 20 | Contract responsibility systems and productive ef ficiency: a case study on state-owned enterprises in China显示文摘 | Wang X | 1998 | Bulletin of Eco nomic Research1998，50，4： | 1 |
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